Modulation of the functions of osteoblast-like cells on poly(allylamine hydrochloride) and poly(acrylic acid) multilayer films

Chien, Hsiu‐Wen; Tan, Siew‐Ann; Wei, Kuang-Ling; Tsai, Wei‐Bor

doi:10.1016/j.colsurfb.2011.07.005

Cited by 16 publications

(9 citation statements)

References 41 publications

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“…The decrease in cell affinity of COL/HA multilayered films with increasing bilayer numbers is consistent with the results on other polyelectrolyte multilayer (PEM) systems [17,25,26]. The bioinertness of the PEM films is correlated well with their thickness.…”

Section: The Adhesion and Activation Of Raw 2657 Cells On The Col/hasupporting

confidence: 86%

Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Hsieh

Chen

et al. 2014

ISRN Biomaterials

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Biological response against foreign implants often leads to encapsulation, possibly resulting in malfunction of implants devices. The aim of this study was to reduce the foreign body reaction by surface modification of biomaterials through layer-by-layer deposition of type I collagen (COL)/hyaluronic acid (HA) multilayer films. Polydimethylsiloxane (PDMS) samples were coated with alternative COL and HA layers with different layers. We found that the in vitro adhesion, proliferation, and activation of macrophage-like cells were greatly decreased by COL/HA multilayered deposition. The PDMS samples modified with 20 bilayers of COL/HA were implanted in rats for 3 weeks, and the thickness of encapsulation surrounding the samples was decreased by 29–57% compared to the control unmodified PDMS. This study demonstrates the potential of COL/HA multilayer films to reduce foreign body reaction.

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Section: The Adhesion and Activation Of Raw 2657 Cells On The Col/hasupporting

confidence: 86%

Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Hsieh

Chen

et al. 2014

ISRN Biomaterials

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“…It is usually thought that cells could recognize plasma proteins adsorbed on the film surface, which subsequently affects cell uptake. (Chien et al, 2011). A previous study demonstrated that proteins could be readily adsorbed onto opposite charge polyelectrolytes, and even onto the similarly charge electrolytes due to secondary interactions and the overall multifaceted character of the protein (Chien et al, 2011).…”

Section: Cellular Internalization 19mentioning

confidence: 97%

Layer-by-layer engineered nanocapsules of curcumin with improved cell activity

Kittitheeranun

Sajomsang

Phanpee

et al. 2015

International Journal of Pharmaceutics

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“…In parallel to these physicochemical results, three main biological key points were assessed: biomolecule and protein adsorption, monocyte activation, and using rat blood: plasma protein interaction and hemolysis of whole blood. First, nanostructured film interaction with biomolecules and proteins is considered as a pivotal parameter that will assess its compatibility . Therefore, a redox molecule and two proteins presently used at their plasmatic concentrations were selected: reduced glutathione (GSH; 10 × 10 −6 m ) as it easily reacts with AuNP, albumin since it is quantitatively the most important protein in human blood (38–48 g L −1 ) and fibrinogen (2–4 g L −1 ) which plays a critical role in platelet adhesion and activation ( Figure A–C) …”

Section: Resultsmentioning

confidence: 99%

Blood Compatibility of Multilayered Polyelectrolyte Films Containing Immobilized Gold Nanoparticles

Pallotta

Parent

Clarot

et al. 2016

Part. Part. Syst. Charact.

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Surface material functionalization including layer‐by‐layer (LbL) polyelectrolyte films with incorporated nanoparticles is a growing field with a wide range of biomedical applications: drug reservoirs, medical devices, or tissue engineering. In parallel, gold nanoparticles (AuNPs) can be grafted by drugs and sensitive molecules using simple protocols. This study shows that AuNP behavior is modified when they are entrapped into three partner LbL films in comparison to the colloidal solution. A polycationic (polyallylamine hydrochloride (PAH)) and a polyanionic (polyacrylic acid (PAA)) polymer is used to build films based on three cycles ((PAH/AuNP/PAA)3). To investigate the interaction with biomolecules and cells, three different films are developed changing the outer layer (either PAH or AuNP or PAA) with the same number of AuNP deposit. The best biocompatibility is observed with a polyacrylic acid outer layer. Due to the high capacity of drug grafting on gold nanoparticles, the results seem promising for the development of nanostructured biomedical devices.

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Modulation of the functions of osteoblast-like cells on poly(allylamine hydrochloride) and poly(acrylic acid) multilayer films

Cited by 16 publications

References 41 publications

Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Layer-by-layer engineered nanocapsules of curcumin with improved cell activity

Blood Compatibility of Multilayered Polyelectrolyte Films Containing Immobilized Gold Nanoparticles

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