“…One of the strategies used to improve the stability of nanostructures in gastro conditions, is the application of a coating to prevent the hydrolysis of proteins by proteolytic enzymes (Somchue et al, 2009). Layer-by-Layer (LbL) deposition technique is one of the methods used in different templates (from hard and planar to rigid particles, and more recently in soft and porous templates such as nanohydrogels) to improve the stability, functional and mechanical properties of different structures (Boddohi, Almod ovar, Zhang, Johnson, & Kipper, 2010;Hirsj€ arvi, Qiao, Royere, Bibette, & Benoit, 2010;Kittitheeranun et al;Kotov, 2003;Sato, Yoshida, Takahashi, & Anzai, 2011;Wong, Müller, Díez-Pascual, & Richtering, 2009). LbL assembly is based on the electrostatic interaction between oppositely charged polyelectrolytes alternatively adsorbed onto an appropriate template (Decher, 2003).…”