Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Hsieh, Cindy Yi Chi; Hu, Fang‐Wei; Chen, Wen-Shiang; Tsai, Wei‐Bor

doi:10.1155/2014/718432

Cited by 18 publications

(15 citation statements)

References 44 publications

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“…Another application, especially of multilayer‐assembled or ‐coated microcapsules/‐beads, represents the transport of drugs, since the association with specific binding molecules such as GAGs can prevent drugs from rapid release and degradation, and act as a target‐oriented delivery system (De Koker et al, ). Multilayer coatings made of GAGs showed in vitro and in vivo macrophage activation, and decrease of capsule formation in vivo , which is related to their anti‐inflammatory properties (Hsieh et al, ; Zhou et al, 2016).…”

Section: Applications Of Glycosaminoglycans In 2d and 3d Systems In Tmentioning

confidence: 99%

“…Porous mesh Artificial ECM, Cartilage regeneration Ji et al, 2006;Zhong et al, 2007) Crosslinked Collagen-HS matrices + bFGF Porous scaffold Enhancement of angiogenesis/ regeneration (Pieper et al, 2002) (Xu et al, 2011) Thiolated Hep-PEG Nanoparticles (Nanogels) Drug delivery, cancer therapy (Bae et al, 2008) degradation, and act as a target-oriented delivery system (De Koker et al, 2012). Multilayer coatings made of GAGs showed in vitro and in vivo macrophage activation, and decrease of capsule formation in vivo, which is related to their anti-inflammatory properties (Hsieh et al, 2014;Zhou et al, 2016). For biomedical applications, a certain durability of the coating plays a crucial role.…”

Section: Porous Scaffoldmentioning

confidence: 99%

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Medical application of glycosaminoglycans: a review

Köwitsch

Zhou

Groth

2017

J Tissue Eng Regen Med

180

145

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The characteristic molecular composition of the different glycosaminoglycans (GAGs) is related to their role as structural components and regulators of a multitude of functions of proteins, cells and tissues in the human body. Therefore, it is not surprising that GAGs are widely used as coating materials for implants, components of 3D-constructs such as tissue engineering scaffolds and hydrogels, but also as diagnostic devices such as biosensors and in controlled release applications. Beside a physisorption or encapsulation of GAGs, these applications often require their chemical modification to allow a stable covalent attachment on surfaces or cross-linking reactions with other molecules. Then, the preservation of the functionality of GAGs under maintenance of their biocompatibility is a challenging task and must be addressed in accordance with the designated field of application. Here, we will give a brief overview on structure and biological functions of GAGs, different methods of their activation and immobilization, the recent progress in GAG-related biomaterials development, as well as some examples of their application in the field of tissue engineering and regenerative medicine.

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Section: Applications Of Glycosaminoglycans In 2d and 3d Systems In Tmentioning

confidence: 99%

Section: Porous Scaffoldmentioning

confidence: 99%

Medical application of glycosaminoglycans: a review

Köwitsch

Zhou

Groth

2017

J Tissue Eng Regen Med

180

145

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“…The cause of capsular contracture might be bacterial infection, implant shell rupture, and hematoma, but nevertheless interaction between implant and the surrounding injured tissue. Implant surface modification of biomaterials to reduce the capsular thickness is proved, which may be due to down regulation of macrophage adhesion and activation [12]. However, possible mechanism is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Cross-Linked Hyaluronic acid can Prevent the Capsular Contracture Formation

Chou¹,

Hsu²,

Hsu³

et al. 2017

Gen Med

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Introduction: Breast reconstruction using silicone implants is a widespread choice, however, breast capsular contracture (BCC), a response of the immune system to foreign materials, is the most affliction and frustration fibrosis complications after silicone implantation. Chronic inflammation-associated fibrosis is regarded as a main cause of BCC. Hyaluronic acid (HA) is an effective anti-adhesive and anti-fibrotic agent. Furthermore, 1,4-butanediol diglycidyl ether-cross-linked hyaluronan hydrogel (cHA) is a non-resorbable cross-linked hyaluronan-derived polymer with no cytotoxicity and high stability. This study aims to evaluate the potential of cHA on preventing BCC in breast surgery using silicone implants.

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“…In contrast to synthetics, organic biomaterials and hydrogels composed of ECM components, collagen (Suri and Schmidt, 2010 ), hyaluronic acid (Hsieh et al, 2014 ), fibrin (Ahmed et al, 2008 ), and alginate (Banerjee et al, 2009 ) represent a better choice, because they exhibit superior biocompatibility (Kim et al, 2007 ; Fujihara et al, 2010 ) and have been shown to effectively regulate the macrophage adhesion and activation in vitro , as well as the capsule formation in vivo (Hsieh et al, 2014 ). Previous studies have found that allogeneic human ECM proteins are well tolerated by the host and do not appear to elicit either a cell mediated or humoral immune response (Allaire et al, 1994 , 1997 ).…”

Section: Possible Strategies To Reduce Fbrmentioning

confidence: 99%

Invasive Intraneural Interfaces: Foreign Body Reaction Issues

et al. 2017

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Intraneural interfaces are stimulation/registration devices designed to couple the peripheral nervous system (PNS) with the environment. Over the last years, their use has increased in a wide range of applications, such as the control of a new generation of neural-interfaced prostheses. At present, the success of this technology is limited by an electrical impedance increase, due to an inflammatory response called foreign body reaction (FBR), which leads to the formation of a fibrotic tissue around the interface, eventually causing an inefficient transduction of the electrical signal. Based on recent developments in biomaterials and inflammatory/fibrotic pathologies, we explore and select the biological solutions that might be adopted in the neural interfaces FBR context: modifications of the interface surface, such as organic and synthetic coatings; the use of specific drugs or molecular biology tools to target the microenvironment around the interface; the development of bio-engineered-scaffold to reduce immune response and promote interface-tissue integration. By linking what we believe are the major crucial steps of the FBR process with related solutions, we point out the main issues that future research has to focus on: biocompatibility without losing signal conduction properties, good reproducible in vitro/in vivo models, drugs exhaustion and undesired side effects. The underlined pros and cons of proposed solutions show clearly the importance of a better understanding of all the molecular and cellular pathways involved and the need of a multi-target action based on a bio-engineered combination approach.

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Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Cited by 18 publications

References 44 publications

Medical application of glycosaminoglycans: a review

Medical application of glycosaminoglycans: a review

Cross-Linked Hyaluronic acid can Prevent the Capsular Contracture Formation

Invasive Intraneural Interfaces: Foreign Body Reaction Issues

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