“…In contrast to synthetics, organic biomaterials and hydrogels composed of ECM components, collagen (Suri and Schmidt, 2010 ), hyaluronic acid (Hsieh et al, 2014 ), fibrin (Ahmed et al, 2008 ), and alginate (Banerjee et al, 2009 ) represent a better choice, because they exhibit superior biocompatibility (Kim et al, 2007 ; Fujihara et al, 2010 ) and have been shown to effectively regulate the macrophage adhesion and activation in vitro , as well as the capsule formation in vivo (Hsieh et al, 2014 ). Previous studies have found that allogeneic human ECM proteins are well tolerated by the host and do not appear to elicit either a cell mediated or humoral immune response (Allaire et al, 1994 , 1997 ).…”