Modulation of prenatal stress via docosahexaenoic acid supplementation: implications for child mental health

Keenan, Kate; Hipwell, Alison E.

doi:10.1093/nutrit/nuu020

Cited by 8 publications

(6 citation statements)

References 76 publications

(77 reference statements)

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“…The slightly lower than average rate of preterm delivery may be due to recruiting from a women’s hospital with a very high level of care. Access to prenatal services that prolong gestation across both groups may have led to difficulties in determining effects of fatty acid supplementation on gestation, an effect that has been fairly consistent in other studies (Keenan and Hipwell, 2015). …”

Section: Discussionsupporting

confidence: 58%

“…One possible reason for the lack of consistent findings is that the effects of DHA supplementation may be most evident among vulnerable populations in terms high levels of stress exposure, and/or in terms of offspring functioning under conditions of stress. In the majority of experimental animal studies, effects of DHA supplementation on offspring functioning were observed under conditions of manipulated prenatal stress and/or manipulated stress exposure in the offspring as opposed to typical functioning (Keenan and Hipwell, 2015). …”

Section: Introductionmentioning

confidence: 99%

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The effect of prenatal docosahexaenoic acid supplementation on infant outcomes in African American women living in low-income environments: A randomized, controlled trial

Keenan

Hipwell

McAloon

et al. 2016

Psychoneuroendocrinology

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Importance African American women living in urban, low-income environments are at high risk for poor nutrition during pregnancy and birth complications. Objective To test the effectiveness of prenatal docosahexaenoic acid (DHA) supplementation on birth outcomes and infant development in a sample of African American women with Medicaid insurance and living in the city of Pittsburgh. Design The Nutrition and Pregnancy Study (NAPS) is a double-blind, randomized controlled trial of prenatal DHA supplementation conducted between 2012 and 2014. Setting Participants were recruited from obstetric clinics at the University of Pittsburgh Medical Center. Participants Sixty-four pregnant, African American women were enrolled at 16–21 weeks of gestation and randomized to either 450 mg/day of DHA (22:6n-3)(n=43) or a soybean placebo (n=21). Four women (6.3%) withdrew from the study: two participants from each study arm; complete data were obtained for 49 infants (76.5%) at the 3-month assessment. Interventions Supplementation with DHA or placebo continued from the beginning of enrollment through delivery. Main Outcome and Measures Data on birth outcomes were collected from medical records. At approximately 3 months post-partum, mothers brought their infants to the laboratory where the Bayley Scales of Infant Development (BSID-III) were administered and cortisol response to the Face-to-Face Still-Face (FFSF) paradigm was assessed. Results Infants of mothers who received DHA supplementation had higher birth weight (3,174 grams versus 2,890 grams) than infants of mothers receiving placebo (F [2,40] = 6.09, p = .018, eta = .36), and were more likely to have a 1-minute Apgar score greater than 8 (OR = 5.99 [95% CI = 1.25–28.75], p = .025). Infants of mothers who received DHA compared with infants of mothers receiving placebo had lower levels of cortisol in response to the FFSF paradigm (F [1,32] = 5.36, p = .018, eta = .36). None of the scores on the BSID-III differed as a function of active supplement versus placebo. Conclusions Infants of women living in urban, low-income environments who received DHA supplementation had more optimal birth outcomes and more modulated cortisol response to a stressor. DHA supplementation may be effective in attenuating the negative effects of prenatal stress on offspring development.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

The effect of prenatal docosahexaenoic acid supplementation on infant outcomes in African American women living in low-income environments: A randomized, controlled trial

Keenan

Hipwell

McAloon

et al. 2016

Psychoneuroendocrinology

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“…Maternal exposure to environmental stressors during the prenatal period is one such condition that has been consistently linked with suboptimal developmental outcomes in the offspring. For example, evidence from animal studies demonstrates that maternal stress during pregnancy can permanently compromise offspring neurodevelopment (Chapillon et al, 2002; Weinstock, 2005) as evidenced by disturbances in executive function (Keenan & Hipwell, 2015; Schneider et al, 2002), impaired learning and disruption in neurogenesis (Chapillon et al, 2002; Coe, Lulbach & Schneider, 2002) and heightened anxiety-like behaviors (Schneider et al, 2002). The strength of the causal claim that maternal stress has a direct impact on offspring development is based on rigorous controlled experiments in animals, including distinguishing prenatal from postnatal effects using methods such as cross-fostering or nursery rearing.…”

Section: Developmental Origins Of Health and Diseasementioning

confidence: 99%

Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

Keenan

Hipwell

Class

et al. 2018

Developmental Psychobiology

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The concept of the developmental origins of health and disease via prenatal programming has informed many etiologic models of health and development. Extensive experimental research in non-human animal models has revealed the impact of in utero exposure to stress on fetal development and neurodevelopment later in life. Stress exposure, however, is unlikely to occur de novo following conception, and pregnancy health is not independent of the health of the system prior to conception. For these reasons, the preconception period is emerging as an important new focus for research on adverse birth outcomes and offspring neurodevelopment. In this review, we summarize the existing evidence for the role of preconception stress exposure on pregnancy health and offspring neurodevelopment across species and discuss the implications of this model for addressing health disparities in obstetrics and offspring outcomes.

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“…Hluti barnshafandi kvenna virtist ekki fullnaegja þörf fyrir naeringarefni á borð við joð, D-vítamín og DHA, sem öll gegna lykilhlutverki við fósturþroska. [17][18][19][20] Lítil gaeði heildarmataraeðis hér á landi eru í samraemi við niðurstöður erlendra rannsókna. [21][22] Hins vegar virtist haetta á ofneyslu vítamína og steinefna ekki vera til staðar miðað við þá neyslu faeðu og faeðubótarefna sem skráð var í matardagbaekurnar.…”

Section: Umraeðaunclassified

Fæðuval og næring kvenna á meðgöngu með tilliti til líkamsþyngdar

Gunnarsdóttir¹,

Tryggvadóttir²,

Birgisdóttir³

et al. 2016

LBL

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InngangurRannsóknir síðastliðinna 20 ára, baeði meðal manna og dýra, benda til þess að umhverfi fósturs í móðurkviði geti haft umtalsverð áhrif á heilsu afkvaemisins allt fram á fullorðinsár.1 Naeringarástand fyrir og á með-göngu getur ekki aðeins haft áhrif á heilsu móðurinn-ar heldur einnig á þroska, vöxt og heilsu barnsins til skemmri og lengri tíma. [2][3][4] Mataraeði mismunandi samfélagshópa hefur verið rannsakað hérlendis undanfarin ár. 5,6 Þekkingin hefur meðal annars nýst við stefnumótun í lýðheilsumálum. Mataraeði barnshafandi kvenna hefur verið rannsakað þrisvar sinnum síðastliðin 15 ár. 7-9 Tíðnispurningalisti var notaður til að kanna mataraeði í öllum þessum rannsóknum. Þrátt fyrir að reynslan af notkun slíks spurningalista sé góð í stórum faraldsfraeðilegum rannsókn-um þar sem aetlunin er að flokka einstaklinga í hópa eftir faeðuvali og tengja við heilsufarsþaetti 10-13 hentar þessi aðferðafraeði illa ef markmiðið er að magngreina neyslu matvaela og einstakra naeringarefna. Nákvaem-ar upplýsingar um neyslu matvaelategunda eru meðal annars mikilvaegar við að meta haettu á of mikilli eða lítilli neyslu naeringarefna miðað við ráðleggingar.14 Markmið rannsóknarinnar var að kanna faeðuval og naeringargildi faeðu meðal barnshafandi kvenna á höfuðborgarsvaeðinu, með áherslu á naeringarefni sem er talið að geti tengst fósturþroska. Notuð var vigtuð skráning alls matar og drykkjar sem konurnar neyttu í fjóra samfellda daga, sem er ein nákvaemasta aðferð sem völ er á við könnun á mataraeði einstaklinga. 10Tilgangur: Naeringarástand fyrir og á meðgöngu getur haft áhrif á þroska, vöxt og heilsu barnsins til skemmri og lengri tíma. Markmið rannsóknar-innar var að rannsaka naeringargildi faeðu hjá barnshafandi konum á höfuðborgarsvaeðinu og að kanna hvort mataraeði kvenna í kjörþyngd fyrir þungun vaeri frábrugðið því sem er hjá konum sem voru yfir kjörþyngd. Efniviður/aðferðir: Þátttakendur voru konur á aldrinum 18-40 ára (n=183), sem höfðu búsetu á höfuðborgarsvaeðinu. Mataraeði var kannað með fjögurra daga vigtaðri skráningu í 19.-24. viku meðgöngu (n=98 með líkamsþyngdarstuðull (LÞS) <25 kg/m 2 ); n=46 með LÞS 25-29,9 kg/m 2 og n=39 með LÞS ≥30 kg/m 2 ). Niðurstöður: Einungis 20% kvennanna náðu lágmarksviðmiðum trefjaneyslu sem eru 25 g á dag. Viðbaettur sykur veitti að jafnaði 12% (SF ± 5%) af heildarorku faeðisins. Um fjórðungur kvennanna gaeti hafa átt á haettu að fullnaegja ekki þörf fyrir joð, D-vítamín og DHA (dókósahexen-sýru ). Ofneysla vítamína og steinefna (úr faeði og baetiefnum) sást ekki. Miðgildi neyslu á mjólk og mjólkurvörum (346 g/dag miðað við 258 g/dag, p<0,05), gos-og svaladrykkjum (200 g/dag miðað við 122 g/dag, p<0,05) og kartöfluflögum og poppi (13 g/dag miðað við 0 g/dag, p<0,05) var haerra meðal kvenna með LÞS ≥30 kg/m 2 fyrir þungun heldur en kvenna sem voru í kjörþyngd fyrir þungun. Ályktanir: Huga þarf betur að faeðuvali kvenna fyrir og á meðgöngu, ekki síst meðal kvenna yfir kjörþyngd. Hluti barnshafandi kvenna fullnaegir ekki þörf fyrir naeringarefni á borð við joð, D-vítamín og...

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Modulation of prenatal stress via docosahexaenoic acid supplementation: implications for child mental health

Cited by 8 publications

References 76 publications

The effect of prenatal docosahexaenoic acid supplementation on infant outcomes in African American women living in low-income environments: A randomized, controlled trial

The effect of prenatal docosahexaenoic acid supplementation on infant outcomes in African American women living in low-income environments: A randomized, controlled trial

Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

Fæðuval og næring kvenna á meðgöngu með tilliti til líkamsþyngdar

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