Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

Keenan, Kate; Hipwell, Alison E.; Class, Quetzal A.; Mbayiwa, Kimberley

doi:10.1002/dev.21773

Cited by 58 publications

(71 citation statements)

References 122 publications

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“…There may be factors which our study did not take into account, such as parent–child interactions, which could be less stimulating or more negative in socially isolated and socioeconomically disadvantaged families [Kiernan & Huerta, ]. Additionally, negative life events and lack of social support could increase maternal allostatic load and chronic stress [Keenan, Hipwell, Class, & Mbayiwa, ; Lecompte, Richard‐Fortier, & Rousseau, ; van den Bergh et al, ], which might negatively affect brain development from pregnancy onward.…”

Section: Discussionmentioning

confidence: 99%

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

et al. 2019

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A growing body of evidence suggests that children of immigrants may have increased risks of neurodevelopmental disorders. However, evidence based on parent report and on very young children is lacking. We therefore investigated the association between maternal immigrant status and early signs of neurodevelopmental problems in a population‐based sample of 2‐year‐old children using standardized parent‐report instruments. We used data from the French representative Étude Longitudinale Française depuis l'Enfance birth cohort, initiated in 2011. The study sample included 9,900 children of nonimmigrant French, 1,403 children of second, and 1,171 children of first generation immigrant women followed‐up to age 2 years. Neurodevelopment was assessed using the Modified Checklist for Autism in Toddlers (M‐CHAT) and an adaptation of the MacArthur‐Bates Communicative Development Inventories (MB‐CDI). In fully adjusted linear regression models, maternal immigrant status was associated with M‐CHAT scores, with stronger associations in children of first (β‐coefficient: 0.19; 95% CI 0.08–0.29) than second generation immigrants (0.09; 0.01–0.17). This association was especially strong among children of first generation immigrant mothers native of North Africa (vs. nonimmigrant French: 0.33; 0.16–0.49) and French‐speaking Sub‐Saharan Africa (0.26; 0.07–0.45). MB‐CDI scores were lowest among children of first generation immigrant mothers, particularly from mostly non‐francophone regions. Children of first generation immigrant mothers were most likely to have simultaneously low MB‐CDI and high M‐CHAT scores. Our findings suggest that maternal immigrant status is associated with early signs of neurodevelopmental difficulties, with strong variations according to maternal region of origin. Further research is necessary to test whether these associations persist and to determine the underlying mechanisms. Autism Res 2019, 12: 1845–1859. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We asked immigrant and nonimmigrant mothers in France about early signs of neurodevelopmental problems in their 2‐year‐old children. Overall, we found that children of immigrants may be at higher risk of showing these early warning signs, as compared to children of nonimmigrants. This is in line with previous studies, which were based on doctors' diagnoses at later ages. However, our results differed depending on the mothers' regions of origin. We found the highest risks in children of first generation immigrants from North and French‐speaking Sub‐Saharan Africa, who also seemed especially at risk of neurodevelopmental problems combined with low language development.

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Section: Discussionmentioning

confidence: 99%

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

et al. 2019

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“…Further, emerging findings also link maternal stress-related exposures before pregnancy to infant behavior and affect (Hipwell et al, 2019;Petzoldt et al, 2015;Spry et al, 2019). Evidence from animal studies suggests preconception programming of the germline or reproductive biology by both maternal and paternal preconception stress, impacting the future gestational environment and fetal development (Keenan et al, 2018;Klengel et al, 2015). Alternative explanations include confounding by common causes, or mediation by perinatal processes.…”

Section: Does Timing Of Parent Internalizing Symptoms or Infant Na Mamentioning

confidence: 99%

Maternal and paternal depression and anxiety and offspring infant negative affectivity: A systematic review and meta-analysis

Spry

Aarsman

Youssef

et al. 2020

Developmental Review

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Maternal internalizing symptoms during pregnancy, specifically depression and/or anxiety, are commonly linked to negative affectivity (NA) in infant offspring. These links are commonly attributed to biological effects of the in utero environment on fetal development. However, research suggests that internalizing symptoms before and after pregnancy, as well as in fathers, may also be associated with NA in infant offspring. Such findings suggest greater complexity in transmission than can be explained by biological in utero programming alone. Further, infant NA is often treated as an homogenous construct, yet it covers a range of facets including fear, frustration, sadness, and slow recovery from distress that may each be differentially associated with parent internalizing distress. Here we aimed to (1) meta-analytically quantify associations between maternal and paternal internalizing symptoms and infant offspring NA, (2) examine how associations varied as a function of distinct phenotypic facets of NA, and (3) examine how associations varied by timing of parental symptoms (preconception, antenatal, postnatal) and infant age. Using random-effects meta-analysis, we found that maternal internalizing symptoms were positively associated with infant NA (r = 0.17 [95% CI 0.14, 0.21], 42 studies, 149 estimates). Preliminary evidence from studies of fathers likewise suggested a positive association with infant NA (r = 0.13 [95% CI 0.04, 0.22], 6 studies, 40 estimates). We observed associations with the global infant NA construct, as well as effect modification by infant NA facet (maternal r range .12 to .22; paternal r range .03 to.21). In mothers, there was no evidence of effect modification by timing of internalizing symptoms or infant age; in fathers, preliminary associations were larger for postnatal than antenatal symptoms. Further studies of preconception and paternal symptoms are now needed, and we suggest avenues for research to advance understanding of the relations between parent internalizing symptoms and infant NA.

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“…Maternal and paternal preconception exposures, including obesity, substance use, and education all predict patterns of offspring development [7] . In experimental animal research, parental preconception stress has been linked to offspring development via enduring effects on parental reproductive biology [8] . These findings point to an influence of preconception stress on offspring development even in the absence of antenatal exposure.…”

Section: Introductionmentioning

confidence: 99%

Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure

et al. 2020

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Background Preterm birth (PTB) and small for gestational age (SGA) are increasingly prevalent, with major consequences for health and development into later life. There is emerging evidence that some risk processes begin before pregnancy. We report on associations between maternal and paternal common mental disorders (CMD) before and during pregnancy and offspring PTB and SGA. Methods 398 women with 609 infants and 267 men with 421 infants were assessed repeatedly for CMD symptoms before pregnancy between age 14 and 29 and during pregnancy. Associations between preconception and antenatal CMD symptoms and offspring gestational age/PTB and size for gestational age/SGA were estimated using linear and Poisson regression. Findings In men, persistent preconception CMD across adolescence and young adulthood predicted offspring PTB after adjustment for ethnicity, education, BMI and adolescent substance use (adjusted RR 7·0, 95% CI 1·8,26·8), corresponding to a population attributable fraction of 31% of preterm births. In women, antenatal CMD symptoms predicted offspring PTB (adjusted RR 4·4, 95% CI 1·4,14·1). There was little evidence of associations with SGA. Interpretation This first report of an association between paternal preconception mental health and offspring gestational age, while requiring replication in larger samples, complements earlier work on stress in animals, and further strengthens the case for expanding preconception mental health care to both men and women. Funding National Health and Medical Research Council (Australia), Victorian Health Promotion Foundation, Australian Rotary Health, Colonial Foundation, Perpetual Trustees, Financial Markets Foundation for Children (Australia), Royal Children's Hospital Foundation, Murdoch Children's Research Institute, Australian Research Council.

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Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

Cited by 58 publications

References 122 publications

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

Maternal and paternal depression and anxiety and offspring infant negative affectivity: A systematic review and meta-analysis

Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure

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