Modeling cyclic variations in sustained human performance as measured by reaction time and the flash visual evoked potential-P2

Case, Jason L.; Arruda, James E.; VanWormer, Lisa A.

doi:10.1016/j.ijpsycho.2016.01.006

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…In a recent review of the flash visual evoked potential P2 (FVEP-P2) literature, Arruda and colleagues 1 examined the diagnostic accuracy of the FVEP-P2 when used as a biomarker for amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD). The results of that review, which included the data from 17 empirical investigations, suggested that the FVEP-P2 latency, an index of visual cholinergic functioning 2–6 may contain pathognomonic information that the more sophisticated approaches of diagnosing aMCI and AD, including cerebral spinal fluid (CSF) and brain imaging (eg, positron emissions tomography, PET) 7–10 may not. It was also noted in the review 1 that unlike today's leading approaches in the detection of AD (ie, CSF-tau and FDG-PET) 7,9 the FVEP-P2 biomarker does not assume the amyloid hypothesis to be true and, therefore, has not been restricted in its approach to the early detection of aMCI and AD.…”

Section: Introductionmentioning

confidence: 99%

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

2022

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Amnestic mild cognitive impairment (aMCI), which is characterized by normal daily activity, but a significant decline in episodic memory, is now widely accepted as a risk factor for the development of Alzheimer's dementia (AD). Research suggests that many of the same neuropathological changes associated with AD also occur in patients diagnosed with aMCI. A recent review of the literature revealed that the latency of the flash visual-evoked potential-P2 (FVEP-P2) may possess pathognomonic information that may assist in the early detection of aMCI. While standards exist for the recording of FVEP-P2, individual clinics often use recording parameters that may differ, resulting in latencies that may not generalize beyond the clinic that produced them. The present article illustrates the process by which the FVEP-P2 latency can be standardized across clinics using FVEP-P2 Conversion Scores. We then demonstrate the diagnostic accuracy of the newly developed scores. Method: In the present investigation, we used the previously unpublished data containing the FVEP-P2 latencies of 45 AD and 60 controls. Result: We were able to demonstrate the process by which individual clinics may first standardize FVEP-P2 latencies and then examine patient performance using FVEP-P2 Conversion Scores, providing clinicians with a richer context from which to examine the patient performance. Conclusion: Consistent with the findings of previous research, the findings of the present investigation support the use of the FVEP-P2 Conversion Scores in the diagnosis of AD. Future directions, including the modification of recording parameters associated with the FVEP-P2, are also discussed.

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Section: Introductionmentioning

confidence: 99%

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

2022

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Reliability of the Flash Visual Evoked Potential P2: Double-Stimulation Study

Wyatt-McElvain

Arruda

Rainey

2018

Appl Psychophysiol Biofeedback

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The flash visual evoked potential P2 (FVEP-P2) has been identified as a potentially useful clinical, diagnostic tool for Alzheimer's dementia (AD) and mild cognitive impairment (MCIa) due to its association with cholinergic functioning in the brain. The FVEP-P2 is the second positive component of the VEP waveform elicited by a single strobe flash. Despite finding a selective delay in the latency of the FVEP-P2 in AD and MCIa groups, adequate levels of sensitivity and specificity have not been achieved due to natural group differences and inter-individual variability. In response, Fix and colleagues introduced a novel, double-stimulation paradigm that contained two strobe flashes (i.e., stimulations). The first stimulation served as a visual challenge while the second stimulation produced the recorded FVEP-P2 component. The results of that investigation indicated that the latency of the FVEP-P2 could be used to reliably discriminate between aMCI and healthy controls when the ISI of the double-stimulation condition was 100 ms or higher. Unfortunately, very little is known regarding the psychometric properties of the FVEP-P2 when produced by a double-stimulation condition. Consequently, we assessed the test-retest reliability of the FVEP-P2 latency produced by a single- and twelve double-stimulation conditions in a sample of young, healthy individuals (N = 20). Results indicated that while the FVEP-P2 latencies produced by the single- and double-stimulation paradigm were reliable, the intra-individual variability continued to be too high for the FVEP-P2 latency to be used clinically. Methods of reducing the intra-individual variability are discussed, including the use of monochromatic light.

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Weighing and prioritization of individual factors affecting the performance of industries firefighters

Heydari

Babamiri

Tapak

et al. 2022

Fire Safety Journal

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Modeling cyclic variations in sustained human performance as measured by reaction time and the flash visual evoked potential-P2

Cited by 5 publications

References 27 publications

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

Reliability of the Flash Visual Evoked Potential P2: Double-Stimulation Study

Weighing and prioritization of individual factors affecting the performance of industries firefighters

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