Reliability of the Flash Visual Evoked Potential P2: Double-Stimulation Study

Abstract

The flash visual evoked potential P2 (FVEP-P2) has been identified as a potentially useful clinical, diagnostic tool for Alzheimer's dementia (AD) and mild cognitive impairment (MCIa) due to its association with cholinergic functioning in the brain. The FVEP-P2 is the second positive component of the VEP waveform elicited by a single strobe flash. Despite finding a selective delay in the latency of the FVEP-P2 in AD and MCIa groups, adequate levels of sensitivity and specificity have not been achieved due to natural group differences and inter-individual variability. In response, Fix and colleagues introduced a novel, double-stimulation paradigm that contained two strobe flashes (i.e., stimulations). The first stimulation served as a visual challenge while the second stimulation produced the recorded FVEP-P2 component. The results of that investigation indicated that the latency of the FVEP-P2 could be used to reliably discriminate between aMCI and healthy controls when the ISI of the double-stimulation condition was 100 ms or higher. Unfortunately, very little is known regarding the psychometric properties of the FVEP-P2 when produced by a double-stimulation condition. Consequently, we assessed the test-retest reliability of the FVEP-P2 latency produced by a single- and twelve double-stimulation conditions in a sample of young, healthy individuals (N = 20). Results indicated that while the FVEP-P2 latencies produced by the single- and double-stimulation paradigm were reliable, the intra-individual variability continued to be too high for the FVEP-P2 latency to be used clinically. Methods of reducing the intra-individual variability are discussed, including the use of monochromatic light.

Use of VEPs as electrodiagnostic biomarkers of mild cognitive impairment

“…However, F‐VEPs are correlated with the function of the luminance channel of the human visual system. The luminance channel is heavily innervated by cholinergic neurons that may be adversely impacted early in the AD disease process 7 . The major F‐VEP component is the P2 component (about 100 ms) 7 …”

“…The luminance channel is heavily innervated by cholinergic neurons that may be adversely impacted early in the AD disease process 7 . The major F‐VEP component is the P2 component (about 100 ms) 7 …”

“…Their results showed that the P2 latency could be used to reliably discriminate between MCI and healthy controls when the inter‐stimulus interval of the double‐stimulation condition was 100 ms or longer. However, another study 7 argued that the intra‐individual variability continued to be too high for the P2 latency to be used clinically even with the double‐stimulation paradigm.…”

Elektroretinografi Ve Görsel Uyarılmış Potansiyel Ölçümlerinde Zenon Ve LED Işık Kaynaklarının Karşılaştırılması

“…Görme keskinliğinin nesnel değerlendirmesi ve ambliyopi izlemi için kullanılabildiği gibi (5), multipl skleroz ya da diğer nedenlere bağlı optik nörit tanısında da sıklıkla kullanılmaktadır (6). Manyetik rezonans görüntüleme ile karşılaştırıldığında daha düşük maliyetli ve daha fazla lezyon saptama oranına sahip olduğu belirtilmiştir (7)(8). Ayrıca yakın zamanda GUP çıktılarından olan P2 dalgasının santral kolinerjik işlevi yansıttığı ve hafif kognitif bozukluk izlemi ve Alzheimer hastalığı riski değerlendirmesi için de kullanılabileceği bildirilmiştir (9).…”

The Classification of Flash Visual Evoked Potential Based on Deep Learning

“…FlashVEP(FVEP) is a sensitive test for optic nerve injury,and its rapid and inexpensive test is an important tool for primary screening of RP diseases. What's more, FVEP is adopted not only in the field of ophthalmology but also as a good tool in the diagnosis and treatment of Alzheimer's disease [3], multiple sclerosis, and tumors in the pterygoid saddle area [4]. The diagnosis of RP and other diseases related to optic nerve injury depend on the labeling and identification of FVEP signals by professional doctors.…”