Mode of Dermal-Epidermal Adhesion

Omar, Ayman I.; Krebs, A. T.

doi:10.1159/000251453

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…One biopsy was taken immediately after treatment and the other one 24 h later. Light-and electron-microscopic preparations were done as described previously [17,18], …”

Section: Light and Electron Microscopymentioning

confidence: 99%

Induction of Multinucleate Cells by 8-MOP and UV Treatment in vitro and in vivo

Omar¹,

Wiesmann²,

Krebs³

1977

Dermatology

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Fibroblast cells were treated with a single dose of 8-methoxypsoralen (8-MOP) and long-wave UV irradiation in vitro and the cytotoxic effects of the treatment followed up for 5 passages. During the first passage, there was an inhibition in cell proliferation, the induction of chromosomal aberrations and the production of macrocells as well as cells with more than one nucleus. In the subsequent passages, the proliferation rate of the cells gradually normalized but there was a concomitant increase in chromosomal aberrations and in the number of macrocells and multinucleate cells. Specimens, which were taken from the uninvolved skin of psoriatic patients who had been treated between 20 and 40 times with an oral dose of 8-MOP and black light irradiation (PUVA) also revealed the presence of binucleate, tetranucleate and multinucleate epidermal cells as well as binucleate and tetranucleate dermal fibroblasts.

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“…One biopsy was taken immediately after treatment and the other one 24 h later. Light-and electron-microscopic preparations were done as described previously [17,18], …”

Section: Light and Electron Microscopymentioning

confidence: 99%

Induction of Multinucleate Cells by 8-MOP and UV Treatment in vitro and in vivo

Omar¹,

Wiesmann²,

Krebs³

1977

Dermatology

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“…The specimens were embedded in paraffin wax, sectioned in their long axis and stained with hematoxylin and eosin. For electron microscopy, the specimens were prepared as by O mar and Krf.bs [11], but cubes of a few millimeters were cut after an hour in glutaraldehyde before further processing. …”

Section: Light and Electron Microscopic Preparationsmentioning

confidence: 99%

Photo-Onycholysis Induced by 8-Methoxypsoralen

Zala¹,

Omar²,

Krebs³

1977

Dermatology

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Two patients, whom we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation of numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.

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Immunoelectron-microscopical localization of in vivo-bound complement C3 in bullous pemphigoid with the use of the peroxidase-antiperoxidase multistep technique

Maciejewski

Braun‐Falco

Scherer³

1979

Arch Dermatol Res

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In vivo-bound complement C3 in bullous pemphigoid was precisely localized by means of the peroxidase-antiperoxidase multistep technique. In the nonbullous lesions peroxidase deposits filled the lamina lucida completely, i.e., the space between lamina densa and the cell membranes of the basal cells. In developed bullae, the reaction product was located both on the lamina densa and on the surface of separated keratinocytes. These findings may indicate that antigen components in bullous pemphigoid are localized almost exclusively within the ground substance which fills the lamina lucida and covers the surface of the basal cells.

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Mode of Dermal-Epidermal Adhesion

Cited by 6 publications

References 16 publications

Induction of Multinucleate Cells by 8-MOP and UV Treatment <i>in vitro</i> and <i>in vivo</i>

Induction of Multinucleate Cells by 8-MOP and UV Treatment <i>in vitro</i> and <i>in vivo</i>

Photo-Onycholysis Induced by 8-Methoxypsoralen

Immunoelectron-microscopical localization of in vivo-bound complement C3 in bullous pemphigoid with the use of the peroxidase-antiperoxidase multistep technique

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