1977
DOI: 10.1159/000250959
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Induction of Multinucleate Cells by 8-MOP and UV Treatment <i>in vitro</i> and <i>in vivo</i>

Abstract: Fibroblast cells were treated with a single dose of 8-methoxypsoralen (8-MOP) and long-wave UV irradiation in vitro and the cytotoxic effects of the treatment followed up for 5 passages. During the first passage, there was an inhibition in cell proliferation, the induction of chromosomal aberrations and the production of macrocells as well as cells with more than one nucleus. In the subsequent passages, the proliferation rate of the cells gradually normalized but there was a concomitant increase in chromosomal… Show more

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Cited by 18 publications
(13 citation statements)
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“…It appears, therefore, that most of the epidermal cells retain their mitotic ability despite the PUVA insult, and that they replicate with a distorted mitotic mechanism evolving into multinucleate cells. These results are in accordance with the histological findings of the photo-onycholytic nail bed which had revealed the highest number of multinucleate cells [2] as compared with the uninvolved skin of the PUVA-treated psoriatic patients [1], and implicate a temporal factor, namely, that cells in a tissue with a slow turnover would have ample time to germinate into multinucleate cells.…”
Section: Multinucleate Epidermal Cellssupporting
confidence: 88%
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“…It appears, therefore, that most of the epidermal cells retain their mitotic ability despite the PUVA insult, and that they replicate with a distorted mitotic mechanism evolving into multinucleate cells. These results are in accordance with the histological findings of the photo-onycholytic nail bed which had revealed the highest number of multinucleate cells [2] as compared with the uninvolved skin of the PUVA-treated psoriatic patients [1], and implicate a temporal factor, namely, that cells in a tissue with a slow turnover would have ample time to germinate into multinucleate cells.…”
Section: Multinucleate Epidermal Cellssupporting
confidence: 88%
“…Histological sections prepared from biopsies of the uninvolved skin of PUVA-treated psoriatic patients and also the nail bed of patients who had contracted photo-onycholysis due to 8-MOP and sunlight irradiation, like wise revealed the presence of multinucleate epidermal cells and multinucleate fibroblasts [1,2]. These findings disclosed that PUVA treatment virtually had the same effect on the cells in vivo as in vitro.…”
Section: Introductionmentioning
confidence: 69%
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“…Ultrastructural features of MPBD may also be somewhat similar to those of condylomata acuminata in the aspect of showing perinuclear vacuolization of the kératinocytes in the upper epidermis [5] and human papilloma virus like particles in the nuclei of the kératinocytes beneath the horny layer [3], although they are basically similar to the alterations observed in Bowen's disease [5], From the above findings, it seems that the pigmented papules of condylomata acuminata and of MPBD may essentially be the same kind of lesion. Multinucleated epidermal cell with clumped nuclei which is one of the histological characteristics of Bowen's disease and of MPBD has also been observed in nonneoplastic inflammatory conditions [4,6,7,10,12]. Repeated stripping of the horny layer of the epidermis also produces in creased mitotic figures and multinucleation of the kératinocytes [8].…”
Section: Degos's Textbook O F Dermatologymentioning
confidence: 99%