Minor Salivary Gland Duct Changes Due to Obstruction

Eversole, Lewis R.; Sabes, William R.

doi:10.1001/archotol.1971.00770070055004

Cited by 55 publications

(24 citation statements)

References 27 publications

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“…The pathogenesis of mucoceles, has been described as due to the destruction of the excretory ducts of salivary glands, due to traumatic cutting or obstruction, inducing extravasation of sialomucin into the submucosa, which subsequently produces inflammation 2,4,6,7 . However, the complete explanation of the pathogenesis of mucoceles remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Immunohistochemical Characteristics of Mucoceles

2009

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Background: Mucoceles have diverse clinical and histological features. Their pathogenesis remains to be elucidated. Objective: To determine the structural and/or pathogenic differences between two clinically different types of mucoceles. Methods: Seventeen oral mucoceles were examined clinically and immunohistologically. The mucoceles were divided into two groups by their clinical manifestations: papular group (PG) and nodular group (NG). Results: Histologically, granulation tissue formed more frequently in the NG group, while CD4 and CD8 positive cells were more abundant in the PG group. There were no significant differences in the tumor necrosis factor-alpha or the matrix metalloproteinases (MMP)-2 and 9, between the two groups. Conclusion: There were significant differences in the depth of the lesions, granulation tissue formation and infiltrating T lymphocytes between the PG and NP type of mucoceles. These findings suggest that the clinical manifestations may be influenced by the type of inflammatory response and extracellular matrix remodeling. (Ann Dermatol 21(4) 345∼

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Section: Discussionmentioning

confidence: 99%

Clinical and Immunohistochemical Characteristics of Mucoceles

2009

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“…Salivary gland stem and progenitor cells seem to be present in submandibular glands of neonatal and adult rats; 1 they may be localized to the intercalated ducts. 1,3,4 It is our future objective to isolate and identify salivary stem and progenitor cells in FIG. 6.…”

Section: In Vitro Differentiation Of Salivary Cellsmentioning

confidence: 99%

“…It has been demonstrated that the intercalated duct is the source of multipotent cells that may give rise to acinar or myoepithelial cells. 3,4 Other data have shown that acinar cells may be renewed using autologous cell division. 5 In the last 2 decades, a human salivary gland (HSG) cell line was used to study acinar differentiation.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Primary Human Submandibular Gland Cells Cultured on Basement Membrane Extract

Szlávik

Szabó

Vicsek

et al. 2008

Tissue Engineering Part A

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There is no effective treatment for the loss of functional salivary tissue after irradiation for head and neck cancer or the autoimmune disease Sjögren's syndrome. One possible approach is the regeneration of salivary glands from stem cells. The present study aimed to investigate whether small pieces of human submandiblar gland tissue contain elements necessary for the reconstruction of salivary rudiments in vitro via acinar and ductal cell differentiation. Primary submandibular gland (primary total human salivary gland; PTHSG) cells were isolated from human tissue and cultured in vitro using a new method in which single cells form an expanding epithelial monolayer on plastic substrates. Differentiation, morphology, number, and organization of these cells were then followed on basement membrane extract (BME) using RNA quantitation (amylase, claudin-1 (CLN1), CLN3, kallikrein, vimentin), immunohistochemistry (amylase and occludin), viability assay, and videomicroscopy. On the surface of BME, PTHSG cells formed acinotubular structures within 24 h, did not proliferate, and stained for amylase. In cultures derived from half of the donors, the acinar markers amylase and CLN3 were upregulated. The PTHSG culture model suggests that human salivary gland may be capable of regeneration via reorganization and differentiation and that basement membrane components play a crucial role in the morphological and functional differentiation of salivary cells.

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“…In contrast, mucus retention cysts tend to occur in the third to seventh decades of life and more commonly are located on the upper lip or buccal mucosa, usually in association with a salivary stone or other obstruction. 3 The case illustrated in this report comes from a 36 year-old man, who presented with a compressible submucosal nodule of recent onset measuring 1 cm in diameter, located on the lower labial mucosa. The nodule was excised, revealing an ovoid pool of mucin encircled by a histiocyte-rich infiltrate, compressed granulation tissue, and fibrosis ( Figure 1).…”

Section: Discussion Follows On Page 768mentioning

confidence: 99%