Clinical and Immunohistochemical Characteristics of Mucoceles

Abstract

Background: Mucoceles have diverse clinical and histological features. Their pathogenesis remains to be elucidated. Objective: To determine the structural and/or pathogenic differences between two clinically different types of mucoceles. Methods: Seventeen oral mucoceles were examined clinically and immunohistologically. The mucoceles were divided into two groups by their clinical manifestations: papular group (PG) and nodular group (NG). Results: Histologically, granulation tissue formed more frequently in the NG group, while CD4 and CD8 positive cells were more abundant in the PG group. There were no significant differences in the tumor necrosis factor-alpha or the matrix metalloproteinases (MMP)-2 and 9, between the two groups. Conclusion: There were significant differences in the depth of the lesions, granulation tissue formation and infiltrating T lymphocytes between the PG and NP type of mucoceles. These findings suggest that the clinical manifestations may be influenced by the type of inflammatory response and extracellular matrix remodeling. (Ann Dermatol 21(4) 345∼

Non-neoplastic salivary gland lesions: a 15-year study

“…In our study also, lip was the most common site for mucoceles (80.9%). A traumatic etiology is suggested as the pathogenesis of mucoceles and this is supported by its most frequent occurrence on the lip, which is a trauma-prone site [17]. Although mucus retention cysts are reported to be more evenly distributed among intra-oral and major salivary glands [16], in our study they were found more frequently in minor salivary glands (72.2%), especially in lips (44.4%).…”

Excision of Mucocele Using Diode Laser in Lower Lip

“…Depending upon the size and location of mucoceles, the various clinical features include external swelling and interference with mastication, swallowing, and speech and discomfort might occur [7]. Histopathologic examination of mucocele often reveals formation of well-circumscribed, cyst-like space surrounded by granulation tissue and the presence of mucinophages in the collapsed wall of granulation tissue [10]. The adjacent salivary gland tissue should also be present because mucocele should always be removed along with feeder glands/ducts which minimize recurrence of the lesion.…”

Estudo retrospectivo da prevalência de fenômenos de retenção e extravasamento de muco - correlação clínico- histopatológica

“…Esses autores observaram uma maior prevalência das lesões no sexo feminino. No entanto, não há na literatura um consenso a respeito da ocorrência dessas lesões em relação ao gênero, embora outros ratifiquem uma maior frequência em indivíduos do sexo masculino [9][10][11] .…”