Nanotechnology is the study and development of materials at nano levels. It is one of the rapidly growing scientific disciplines due to its enormous potential in creating novel materials that have advanced applications. This technology has tremendously impacted many different science and engineering disciplines, such as electronics, materials science, and polymer engineering. Nanofibers, due to their high surface area and porosity, find applications as filter medium, adsorption layers in protective clothing, etc. Electrospinning has been found to be a viable technique to produce nanofibers. An in-depth review of research activities on the development of nanofibers, fundamental understanding of the electrospinning process, and properties of nanostructured fibrous materials and their applications is provided in this article. A detailed account on the type of fibers that have been electrospun and their characteristics is also elaborated. It is hoped that the overview article will serve as a good reference tool for nanoscience researchers in fibers, textiles, and polymer fields. Furthermore, this article will help with the planning of future research activities and better understanding of nanofiber characteristics and their applications.

Since the recent Deepwater Horizon Gulf of Mexico oil spill, the need for environmentally friendly oil sorbents has intensified. This study deals with the sorption of crude oil by raw cotton, a biodegradable sorbent. To our best knowledge, the data related to crude oil sorption by unprocessed raw cotton and correlation with cotton characteristics such as micronaire, fineness, and maturity are unavailable. More importantly, our work quantifies the oil sorption (g/g) of low micronaire (immature) cotton. Results showed at the minimum level, low micronaire raw cotton has 30.5 g/g crude oil sorption capacity. Furthermore, the crude oil sorption capacity of low micronaire cotton was significantly higher than the sorption capacity of high micronaire cotton. Brunauer−Emmett−Teller (BET) surface area and environmental scanning electron microscopy analyses support the correlation between the quality characteristics of raw cotton and its oil sorption capacity. In contrast to synthetic sorbents, raw cotton with its high crude oil sorption capacity and positive environmental footprint make it an ecologically friendly sorbent for oil spill cleanups.

Purpose: Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) who had experienced progression within 6 months of platinumcontaining chemotherapy. Patients and Methods: In the randomized, open-label, phase III CheckMate 141 trial, patients were randomized 2:1 to nivolumab 3 mg/kg every 2 weeks or investigator's choice (IC) of single-agent chemotherapy, with stratification by prior cetuximab exposure. The primary endpoint was overall survival (OS); additional endpoints were progression-free survival, objective response rate, and safety. Results: In patients with prior cetuximab exposure, the median OS was 7.1 months with nivolumab versus 5.1 months with IC (HR, 0.84; 95% CI, 0.62-1.15); OS benefit with nivolumab was maintained across most demographic subgroups. In patients without prior cetuximab exposure, the median OS was 8.2 months with nivolumab versus 4.9 months with IC (HR, 0.52; 95% CI, 0.35-0.77); OS benefit with nivolumab was maintained across patient baseline subgroups including tumor programmed death ligand 1 (PD-L1) expression (<1% or !1%). Grade 3-4 treatment-related adverse event rates favored nivolumab versus IC in both subgroups. Conclusions: Nivolumab appeared to improve efficacy versus IC regardless of prior cetuximab use, supporting its use in patients with R/M SCCHN with or without prior cetuximab exposure. The reduction in risk of death with nivolumab compared with IC was greater in patients without prior cetuximab exposure versus with prior cetuximab exposure.

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Electrospinning uses a high voltage electric field to produce fine fibers. A new phenomenon of selfassembly in the electrospinning of polyurethane nanofibers is observed. This report is the first known self-assembling phenomenon in polyurethane electrospun nanofibers. Electrospun polyurethane nanofibers self-assemble into unique honeycomb patterns on the collector surface. This novel observation opens up new and interesting opportunities for electrospun fibers in the areas of drug delivery devices, protective clothing, filters, and tissue scaffolds.

A novel sorbent was developed using the aligning of raw unprocessed cotton fibers leading to low-density, hydrophobic, oleophilic, and sustainable cotton batt. Cotton batting developed using immature cotton exhibited oil sorption capacity of 50.27 g/g, which is significantly higher than the oil sorption capacity of many commercial sorbents reported in the literature. Fundamental mechanisms such as adsorption, absorption, and capillary action govern the oil sorption phenomenon, which were verified using environmental scanning electron micrographs. In addition, optical microscopy was used to understand the difference in the longitudinal cross section of the mature (base range) and immature (low micronaire) cotton, which was determined quantitatively using Brunauer–Emmett–Teller surface area analysis. Effect of cotton characteristics such as fineness and maturity on the oil sorption capacity was also investigated. Nonwoven cotton batts consisting of immature and finer cotton fibers showed oil sorption capacity that was 7% higher than that of cotton batts developed using mature and coarser fibers.

Mucoceles are nonneoplastic cystic lesions of major and minor salivary glands which result from the accumulation of mucus. These lesions are most commonly seen in children. Though usually these lesions can be treated by local surgical excision, in our case, to avoid intraoperative surgical complications like bleeding and edema and to enable better healing, excision was done using a diode laser in the wavelength of 940 nm.