Microfluidic chip fabrication using hot embossing and thermal bonding of COP

Pemg, Boe Yu; Wu, Chih Wei; Shen, Yung Kang; Lin, Yi

doi:10.1002/pat.1447

Cited by 36 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bond strength was found to vary depending on the area of the disc, with lowest value of 0.6 MPa measured for the samples taken from the outer edge of the disc. However, even the lowest value is still sufficient for leak-tight device operation and comparable to some previously reported data for COP-COP bonded microfluidic chips 4,13 .…”

Section: Bondingsupporting

confidence: 89%

Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Vereshchagina

Carmona

Andreassen

et al. 2018

2018 IEEE Micro Electro Mechanical Systems (MEMS)

View full text Add to dashboard Cite

Two key issues in the manufacturing of microfluidic devices are to obtain low surface roughness, i.e. in the range of nanometers (to facilitate optical detection and controlled flow through microfluidic networks), and to achieve robust bonding. Here we report that a chemical polishing step, used for smoothening the surface of cycloolefin polymer (COP) components manufactured by micromilling, reduces the surface roughness (to Ra ~ 150 nm) and facilitates a leak-tight COP-COP bond. We report new results on COP structuring and surface characterization by white light interferometry (WLI), infrared spectroscopy (FTIR-ATR), contact angle measurements and transmittance measurements, as well as demonstrations of a functional thermally bonded centrifugal microfluidic devices.

show abstract

Section: Bondingsupporting

confidence: 89%

Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Vereshchagina

Carmona

Andreassen

et al. 2018

2018 IEEE Micro Electro Mechanical Systems (MEMS)

View full text Add to dashboard Cite

show abstract

“…However, UV adhesive also has some limitations in practice, such as poor tolerance to mechanical shock, radiation, and temperature changes [5]. Moreover, when bonding wafers with microchannels, the microchannels are easy to be plugged by UV adhesive [6].…”

Section: Introductionmentioning

confidence: 99%

Patterned wafer bonding using ultraviolet adhesive

Zhuo

Liao

et al. 2011

Front. Mech. Eng.

View full text Add to dashboard Cite

The process of patterned wafer bonding using ultraviolet (UV) adhesive as the intermediate layer was studied. By presetting the UV adhesive guide-layer, controlling the thickness of the intermediate layer (1-1.5 μm), appropriate pre-drying temperature (60°C), and predrying time (6 min), we obtained the intermediate layer bonding of patterned quartz/quartz. Experimental results indicate that patterned wafer bonding using UV adhesive is achieved under room temperature. The process also has advantages of easy operation, low cost, and no plugging or leakage in the patterned area after bonding. Using the process, a microfluidic chip for red blood cell counting was designed and fabricated. Patterned wafer bonding using UV adhesive will have great potential in the fabrication of microfluidic chips.

show abstract

“…Microfluidic devices are often created with photolithography and etching procedures, and for cell culture devices, replica molding by soft lithography in the elastomer PDMS. Other methods for creating microfluidic devices include micromachining, micro injection molding, and hot embossing [141][142][143]. Moreover, with the improvement in resolution, 3D printing has emerged as a realistic option that can combine design flexibility and large-scale manufacturability.…”

Section: = µmentioning

confidence: 99%

Organs-on-chips for the pharmaceutical development process: design perspectives and implementations

Christoffersson¹

View full text Add to dashboard Cite

Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture devices from a design perspective and to experimentally exemplify some of the specific functions that characterize organs-on-chips.The cells in our body reside in complex environments with chemical and mechanical cues that affect their function and purpose. Such a complex environment is difficult to recreate in the laboratory and has therefore been overlooked in favor of more simple models, i.e. static twodimensional (2D) cell cultures. Numerous recent reports have shown cell culture systems that can resemble the cell's natural habitat and enhance cell functionality and thereby potentially provide results that better reflects animal and human trials. The way these organs-on-chips improve in vitro cell culture assays is to include e.g. a three-dimensional cell architecture (3D), mechanical stimuli, gradients of oxygen or nutrients, or by combining several relevant cell types that affect each other in close proximity.The research conducted for this thesis shows how cells in 3D spheroids or in 3D hydrogels can be cultured in perfused microbioreactors. Furthermore, a pump based on electroosmosis, and a method for an objective conceptual design process, is introduced to the field of organs-on-chips.Keywords: Organs-on-chips, cell culture models, pharmaceutical development, microfluidics iv v Populärvetenskaplig sammanfattningOrgans-on-chips är modellsystem med avsikt att återskapa ett organs funktion in vitro genom att odla celler från djur eller människor i en omgivning som efterliknar kroppen. Syftet med dessa modeller är att utvärdera ett potentiellt läkemedels toxicitet och effektivitet så tidigt som möjligt i läkemedelsutvecklingen för att kunna förutsäga hur det påverkar människor. Målet med denna avhandling är att förklara och diskutera denna typ av cellmodeller utifrån ett designperspektiv och experimentellt visa några av de specifika funktioner som är en del av konceptet organs-on-chips.Cellerna i våra kroppar befinner sig komplexa miljöer med kemiska och mekaniska signaler som påverkar deras funktion och syfte. Sådana miljöer är svåra att återskapa på laboratoriet och har därför till stor del förbisetts till fördel för enklare modellsystem som ofta består av celler som odlas på plast-eller glasytor under statiska förhållanden. På senare tid har en betydande mängd publikationer visat på att cellmodeller som bättre kan efterlikna cellens naturliga miljö kan förbättra dess olika funktioner och därmed ge resultat som eventuellt kan matcha försöken som görs på djur och människor. Det finns flera olika funktioner, hämtade från vår kunskap om människans biologi, som organs-on-chips kan implementera för att skapa dessa förbättrade cellmiljöer och inkluderar en tre-...

show abstract

Microfluidic chip fabrication using hot embossing and thermal bonding of COP

Cited by 36 publications

References 10 publications

Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Patterned wafer bonding using ultraviolet adhesive

Organs-on-chips for the pharmaceutical development process: design perspectives and implementations

Contact Info

Product

Resources

About