Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Vereshchagina, Elizaveta; Carmona, Pierre; Andreassen, Erik; Batalden, Jorn; Plassen, Martin; Mielnik, Michał

doi:10.1109/memsys.2018.8346792

Cited by 2 publications

(2 citation statements)

References 11 publications

(12 reference statements)

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“…[ 78–80 ] A surface roughness of 5.7 nm in a 50 µm (diameter or width and height) microfluidic channel, for example, represents a relative roughness of ∼0.01%. Maintaining low surface roughness in microfluidics also has broader implications in facilitating reliable device bonding [ 47,81,82 ] and high optical clarity [ 83,84 ] in thermoplastics. Roughness analyses suggest that the limiting factor in achieving good molding reproduction of surface topography with surface roughness below 10 nm would depend on the roughness of the master mold and not on any roughness inherent to the material itself or resulting from the hot embossing process.…”

Section: Resultsmentioning

confidence: 99%

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

et al. 2021

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A novel fluorinated soft thermoplastic elastomer (sTPE) for microfluidics is presented. It allows the rapid fabrication of microfluidic devices through a 30‐second hot embossing cycle at 220°C followed by self‐sealing through simple conformal contact at room temperature, or with baking. The material shows high chemical resistance, particularly in comparison to polydimethylsiloxane (PDMS), to many common organic solvents and can be rapidly micropatterned with high fidelity using a variety of microfluidic master molds thanks to its low mechanical stiffness. Self‐sealing of the material is reversible and withstands pressures of up to 2.8 bar with room temperature sealing and four bar with baking at 185°C for 2 hours. The elastomeric, transparent sTPE exhibits material characteristics that make it suited for use as a microreactor, such as low absorption, surface roughness and oxygen permeability, while also allowing a facile and scalable fabrication process. Modular microfluidic devices, leveraging the fast and reversible room temperature self‐sealing, are demonstrated for the generation of water droplets in a toluene continuous phase using T‐junctions of variable size. The sTPE offers an alternative to common microfluidic materials, overcoming some of their key drawbacks, and giving scope for low‐cost and high‐throughput devices for flow chemistry applications.

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Section: Resultsmentioning

confidence: 99%

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

et al. 2021

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“…The result indicates that the maximum bonding strength (∼1.35 MPa) could be achieved with the UV exposure duration longer than 30 s. The time span needed for the UV exposure depends on the transmission of the thermoplastic substrate/cover plate in UV range as well as the thickness of the UV curable adhesives. The shear bonding strength achieved between glass plates by Jia et al is around 72.2 ± 4.1 MPa [31], and the shear bonding strength achieved between COP plates is around 15.7 MPa for COP‐based microfluidics [34].…”

Section: Resultsmentioning

confidence: 99%

Application of a new UV curable adhesive for rapid bonding in thermoplastic‐based microfluidics

Zhang

Gao

Fan

2019

Micro & Nano Letters

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This study proposed a rapid and reliable approach for the bonding of thermoplastic-based microfluidics with a new, low-cost, low toxic, and transparent ultraviolet (UV) curable adhesive as the intermediate layer between thermoplastic plates. After laser fabrication of microchannels on the surface of the polymethyl methacrylate (PMMA) substrate, the UV curable adhesive layer is applied between the substrate and cover plate; a flushing process is then conducted for the removal of the adhesive residuals inside the microchannel. Finally, a UV exposure with the wavelength of 365 nm is applied for the crosslinking of adhesives to finish the bonding process. Several microfluidic devices were fabricated and tested for the demonstration of the proposed technique, and the bonding strength was carefully measured with different UV exposure duration. The characteristics of the contact angle and UV-visible spectroscopy of the UV adhesive coated surface are also provided in this study. In addition, a simple biocompatibility test of the UV curable adhesive-coated polymer surface is also conducted in this research to confirm the low toxicity of the adhesive layer. The proposed bonding techniques are broadly applicable to achieve a rapid, low-cost, optically clear, and low toxic bonding for thermoplastic-based microfluidics.

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Simultaneous improvement of surface finish and bonding of centrifugal microfluidic devices in cyclo-olefin polymers

Cited by 2 publications

References 11 publications

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

Application of a new UV curable adhesive for rapid bonding in thermoplastic‐based microfluidics

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