Microencapsulation peptide and protein drugs delivery system

Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification

“…Subsequently, the organic phase is dispersed again into a second water phase giving a Water-Oil-Water (W/O/W) dispersion. With this method both hydrophobic and hydrophilic drugs can be successfully encapsulated [4,5,9,18,19].…”

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

“…Results from the change in size of the particles during release are shown and a release model based on diffusion coupled to particle size change is proposed. In other studies, PLGA may degrade mainly through bulk erosion, [10,[23][24][25][26][27], however, the gradual size change and the images illustrated here suggest that, when encapsulating a water soluble drug by a water-in-oil-in-water (W/O/W) emulsion, both surface and bulk erosion contribute to the polymer degradation. The membrane emulsification apparatus was a dispersion cell provided by Micropore Technologies Ltd, Leicestershire, UK.…”

“…The images show the effects of surface degradation. In [23] the authors saw PLA and PLGA surface erosion when the degradation was conducted in a basic environment.…”

A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels

“…Chitosan and alginate have been used for many biomedical and pharmaceutical purposes, such as peptide and protein delivery, [19][20][21][22][23] due to their low toxicity, low immunogenicity, and high biocompatibility and biodegradability. 24 They can become gelatinized when interacting with calcium ions. In our study, chitosan made the surface of the microparticles positively charged, and these could then react with negatively charged molecules or biological membranes surfaces.…”