PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

Abstract

Particles for subcutaneous depot use encapsulating a model water soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification -solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported.During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented.Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.

In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems

“…Water uptake and degradation properties can be modified when the concentration and type of salt are involved in degradation studies of PLGA or PLA [28,31,32]. In the present work, the visual aspect of the microspheres degraded in the two media was different.…”

The influence of hydrophilic mPEG segment on formation, morphology, and properties of PCL‐mPEG microspheres

“…[1][2][3][4] Microspheres were supposed to be a potential drug delivery system for disease treatment due to its long controlled and sustained drug release. [1][2][3][4] Microspheres were supposed to be a potential drug delivery system for disease treatment due to its long controlled and sustained drug release.…”

“…In recent years, microspheres based on the biodegradable polymers, such as poly (lactide-co-glycolide) (PLGA), poly (lactic acid) (PLA), and poly (ε-caprolactone) (PCL), had attracted great attentions. [1][2][3][4] Microspheres were supposed to be a potential drug delivery system for disease treatment due to its long controlled and sustained drug release. [5][6][7][8] Patient compliance, drug protection, and sustained release were part of the many benefits to encapsulating and releasing a therapeutic agent from polymer microspheres.…”

“…I G U R E 1 Scanning electron micrographs of lysozyme loaded microspheres: (a) PCL (25,000) microspheres; (b) PCL (24,000) -mPEG(1,000) microspheres; (c) PCL (22,000) -mPEG(3,000) microspheres; (d) PCL (20,000) -mPEG(…”

Comparison of the degradation and release behaviors of poly(lactide‐co‐glycolide)–methoxypoly(ethylene glycol) microspheres prepared with single‐ and double‐emulsion evaporation methods

“…In recent years, special attention has been paid to sustained‐release microspheres based on biodegradable polymers, such as poly(lactide‐ co ‐glycolide) (PLGA), poly(lactic acid), and poly(ε‐caprolactone). Patient compliance, drug protection, and sustained release are part of the many benefits to encapsulating and releasing a therapeutic agent from polymer microspheres .…”