Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification

Gasparini, Gilda; Kosvintsev, Serguei R.; Stillwell, Michael T.; Holdich, Richard

doi:10.1016/j.colsurfb.2007.08.011

Cited by 70 publications

(53 citation statements)

References 32 publications

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“…In the previous work, [6], it was shown how PLGA concentration, membrane pore size and osmotic pressure affect particle size and encapsulation efficiency. Osmotic pressure was controlled by varying the concentrations of salt in the inner and outer water phases during particle production.…”

Section: Resultsmentioning

confidence: 99%

“…This study follows from an earlier one [6], where different solidification methods and a variety of operating conditions were considered in order to produce the required size of particles and enhance the encapsulation efficiency, ε.…”

Section: Particle Productionmentioning

confidence: 99%

“…Specifically, its application for PLGA particle production has been reported [6], from which this work follows.…”

Section: Introductionmentioning

confidence: 99%

“…Building on the previous work [6], a range of monosized particles containing a water soluble model drug with high encapsulation efficiency were produced and exposed to release conditions in way not normally reported. Because of the relatively high quantity of particles produced, by employing the lamina surface membrane emulsification technique, it was possible to divide the particles in to ten independent samples, which were subjected to identical model drug release conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Three pore size membranes were used, 7, 20 and 40 µm in diameter, with the same pore distance equal to 200 µm. A more detailed description can be found elsewhere [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

Gasparini

Holdich

Kosvintsev

2010

Colloids and Surfaces B: Biointerfaces

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Particles for subcutaneous depot use encapsulating a model water soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification -solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported.During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented.Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.

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Section: Resultsmentioning

confidence: 99%

Section: Particle Productionmentioning

confidence: 99%

“…Specifically, its application for PLGA particle production has been reported [6], from which this work follows.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Three pore size membranes were used, 7, 20 and 40 µm in diameter, with the same pore distance equal to 200 µm. A more detailed description can be found elsewhere [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

Gasparini

Holdich

Kosvintsev

2010

Colloids and Surfaces B: Biointerfaces

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Membranes for Microfluidic Applications

Vladisavljević

Kobayashi

Nakajima

2013

Encyclopedia of Membrane Science and Technology

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This article provides an overview of major membrane microfluidic techniques for the production and modification of liquid‐liquid and gas‐liquid dispersions and the most common membranes used in these processes. The main emphasis is on Shirasu porous glass (SPG) membrane, microengineered membranes, and single‐crystal silicon microchannel (MC) plates. For each membrane type, fabrication process and microfluidic applications are discussed. SPG membrane is an interconnected‐type membrane fabricated by spinodal decomposition, which has been widely used in membrane emulsification (ME) and membrane micromixing/nanoprecipitation processes leading to the generation of emulsions, micro‐ and nanobubbles, and micro‐ and nanoparticles. Typical microengineered membranes used in microfluidic applications are silicon nitride microsieves fabricated by photolithography and reactive ion etching, nickel membranes fabricated by UV‐LIGA process, and stainless steel membranes with laser‐drilled pores. Microengineered membranes are used in stirred cell, cross‐flow, and pulsating cross‐flow ME systems. In order to prevent damage to shear‐sensitive materials in the product stream, a shear stress on the downstream side of the membrane can be provided using oscillating (vibrating) or spinning (rotating) membrane. MC plates are microchips with 3D architecture consisting of an array of horizontal microgrooves or vertical straight‐through channels integrating with other features such as terrace lines, steps, and cross‐flow channels. They are usually fabricated in single‐crystal silicon by photolithography and anisotropic wet etching or deep reactive ion etching.

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Multifactorial design of poly(d,l‐lactic‐co‐glycolic acid) capsules with various release properties for differently sized filling agents

Schmitz-Hertzberg

Mak

Lai

et al. 2013

J of Applied Polymer Sci

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The hydrolytic degradation and corresponding content release of capsules made of poly(D,L-lactic-co-glycolic acid) (PLGA) strongly depends on the composition and material properties of the initially applied copolymer. Consecutive or simultaneous release from capsule batches of combinable material compositions, therefore, offers high control over the bioavailability of an encapsulated drug. The keynote of this study was the creation of a superordinated database that addressed the correlation between the release kinetics of filling agents with different molecular weights from PLGA capsules of alternating composition. Fluorescein isothiocyanate (FITC)-dextran (with molecular weights of 4, 40, and 2000 kDa) was chosen as a model analyte, whereas the copolymers were taken from various 50:50 PLGA, 75:25 PLGA, and polylactide blends. With reference to recent publications, the capsule properties, such as the size, morphology, and encapsulation efficiency, were further modified during production. Hence, uniform microdisperse and polydisperse submicrometer nanocapsules were prepared by two different water-in-oil-in-water emulsification techniques, and additional effects on the size and morphology were achieved by capsule solidification in two different sodium salt buffers. The qualitative and quantitative examination of the physical capsule properties was performed by confocal laser scanning microscopy, scanning electron microscopy, and Coulter counting techniques to evaluate the capsule size distribution and the morphological appearance of the different batches. The corresponding agent release was quantified by fluorescence measurement of the FITC-dextran in the incubation media and by the direct measurement of the capsule brightness via fluorescence microscopy. In summary, the observed agent release showed a highly controllable flexibility depending on the PLGA blends, preparation methods, and molecular weight of the used filling substances.

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Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification

Cited by 70 publications

References 32 publications

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

Membranes for Microfluidic Applications

Multifactorial design of poly(d,l‐lactic‐co‐glycolic acid) capsules with various release properties for differently sized filling agents

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