Microemulsion-based hydrogels of itraconazole: Evaluation of characteristics and stability

Boonme, Prapaporn; Kaewbanjong, Jarika; Sangduangyang, Sugitta; Suksawat, Suttipa; Teeranachaideekul, Veerawat

doi:10.1016/j.ajps.2015.11.110

Cited by 5 publications

(2 citation statements)

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“…4 A semi-solid form of MEs is one of the new formulas used as a topical delivery system. 5,6 MEs have many features unique as topical and transdermal drug delivery systems. First, the main advantage of these colloidal systems is that a large amount of the drug can be combined owing to the increased solubilization capacity, and therefore the thermodynamic activity in the skin increases with the gradient having a high concentration of the drug present in the ME for the skin.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Dermal Delivery of Finasteride Using MicroemulsionSystems

Soleymani

Salimi

2019

Adv Pharm Bull

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Purpose: Finasteride is a pharmaceutical agent that treats hair loss and acne with hormonal patterns. Due to its poor water solubility, and the smaller surface area in comparison to total skin surface area, penetration of the drug into hair follicles and skin is low. The aim of this research was to formulate, characterize and evaluate in vitro skin permeability of finasteride microemulsions (MEs). Methods: Finasteride MEs were prepared using a pseudo-ternary phase diagram method with an appropriate ratio of oil mixture, surfactant-co-surfactant mixture and water. MEs containing 1% finasteride were prepared with a suitable amount of oily phase and surfactant and cosurfactant. The physicochemical properties of these MEs and in vitro skin permeability of MEs were evaluated. Results: The results showed that the mean droplet size range of ME samples was 5–17 nm and pH was 5.1–5.7. The viscosity of MEs ranged from 86.4–209.6 cps. The drug release profile showed that 49.510% of the drug was released (ME-F-6) over the 24 hours of the experiment. The kinetics of drug release from all selected MEs were approximately described by Higuchi and first-order modeling. All ME formulations with different compositions and properties significantly increased flux and permeability coefficient from rat skin. The selected MEs exhibit 99.9% finasteride after six months of storage. Conclusion: This study showed that any change in the content and composition of MEs could change the physical and chemical properties in addition to ME permeability parameters. The MEs increased permeability of the skin to finasteride.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Dermal Delivery of Finasteride Using MicroemulsionSystems

Soleymani

Salimi

2019

Adv Pharm Bull

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“…Moreover, they are biodegradable, biocompatible and are easily accepted by regulatory authorities (11). The use of polymers such as carbopol (CBP), poloxamer, hydroxylpropyl methylcellulose and natural polymer such as xanthan gum (XG) as gelling agents in the formulation of ME gels were reported in the literatures (2,(12)(13)(14). Tamarind gum (TG) is a natural polymer well known for its applicability in food industry.…”

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confidence: 99%

Microemulsion Based Bioadhesive Gel of Itraconazole Using Tamarind Gum: In-vitro and Ex-vivo Evaluation

Mali¹,

Dhawale²,

Dias³

2017

Marmara Pharmaceutical Journal

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Approximately two third of population throughout the world is affected by a common fungal infection(1). The fungal infections caused by genus Candida, Aspergillus, and Cryptococcus are showing increasing trends of infections more specifically in transplant patients, AIDS patients and cancer patients. The major cause of morbidity and mortality in patients has been invasive fungal infections(2).Itraconazole (ITZ) is a triazole antifungal agent with a wide spectrum of activity. It is well tolerated in patients as compared to other triazoles like fluconazole, ravuconazole, and posaconazole. ITZ is used in the treatment of fungal infections. ITZ is drug of choice in case of immunecompromised and non-immuno compromised patients along with patients who cannot tolerate amphotericin B therapy (3). However, ITZ is a highly hydrophobic weak base and shows inter-individual and intra-individual variability in oral bioavailability. ITZ being BCS class II drug, its absorption

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