Promising Novel Nanopharmaceuticals for Improving Topical Antifungal Drug Delivery

Gupta, Madhu; Sharma, Vasu; Chauhan, Nagendra Singh

doi:10.1016/b978-0-323-52727-9.00011-x

Cited by 24 publications

(29 citation statements)

References 86 publications

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“…The surge in the incidence fungal infections in recent times is due to the increased use of surgical and invasive procedures, immunosuppressants, and antibiotics [2]. Most commonly reported fungal infections are superficial in nature affecting skin, hair, nails, and mucosa however, systemic fungal infections are also reported [1,3]. Superficial fungal infections caused by dermatophytes affect around 40 million people in developed and underdeveloped countries and is the fourth most common cause of infection [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Most commonly reported fungal infections are superficial in nature affecting skin, hair, nails, and mucosa however, systemic fungal infections are also reported [1,3]. Superficial fungal infections caused by dermatophytes affect around 40 million people in developed and underdeveloped countries and is the fourth most common cause of infection [3,4]. Common fungal pathogens responsible for fungal infections include Candida , Aspergillus , Cryptococcus , Scedosporium , Zygomycetes , and other species [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…Superficial fungal infections caused by dermatophytes affect around 40 million people in developed and underdeveloped countries and is the fourth most common cause of infection [3,4]. Common fungal pathogens responsible for fungal infections include Candida , Aspergillus , Cryptococcus , Scedosporium , Zygomycetes , and other species [1,3]. Various antifungal agents are used for the treatment of fungal infections which include azoles (triazoles and imidazoles), allylamines, polyene antibiotics, echinocandins, griseofulvin, and others [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Common fungal pathogens responsible for fungal infections include Candida , Aspergillus , Cryptococcus , Scedosporium , Zygomycetes , and other species [1,3]. Various antifungal agents are used for the treatment of fungal infections which include azoles (triazoles and imidazoles), allylamines, polyene antibiotics, echinocandins, griseofulvin, and others [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Advantages associated with topical formulations include limited systemic bioavailability of the drug, which reduces the systemic adverse effects, potential self-medication, increased patient compliance, and targeted or localized therapy. However, topical preparations have disadvantages such as poor dermal or ungual bioavailability, poor penetration into the stratum corneum, variable drug levels at the site of infection, greasiness or stickiness of ointments and creams, skin irritation, allergic reactions, and uncontrolled evaporation of drugs from the preparation [3,8,9,10,11]. Therefore, there is a need for novel topical formulations to address the problems associated with the current existing formulations.…”

Section: Introductionmentioning

confidence: 99%

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Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies

et al. 2019

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Global incidence of superficial fungal infections caused by dermatophytes is high and affects around 40 million people. It is the fourth most common cause of infection. Clotrimazole, a broad spectrum imidazole antifungal agent is widely used to treat fungal infections. Conventional topical formulations of clotrimazole are intended to treat infections by effective penetration of drugs into the stratum corneum. However, drawbacks such as poor dermal bioavailability, poor penetration, and variable drug levels limit the efficiency. The present study aims to load clotrimazole into ufosomes and evaluate its topical bioavailability. Clotrimazole loaded ufosomes were prepared using cholesterol and sodium oleate by thin film hydration technique and evaluated for size, polydispersity index, and entrapment efficiency to obtain optimized formulation. Optimized formulation was characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). Skin diffusion studies and tape-stripping were performed using human skin to determine the amount of clotrimazole accumulated in different layers of the skin. Results showed that the optimized formulation had vesicle size <250 nm with ~84% entrapment efficiency. XRD and DSC confirmed the entrapment of clotrimazole into ufosomes. No permeation was observed through the skin up to 24 h following the permeation studies. Tape-stripping revealed that ufosomes led to accumulation of more clotrimazole in the skin compared to marketed formulation (Perrigo). Overall, results revealed the capability of ufosomes in improving the skin bioavailability of clotrimazole.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies

et al. 2019

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Application of Nanotechnology in Transdermal Drug Delivery

Singhavi

Khan

2020

Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment

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Nanogels as Antifungal‐Drug Delivery System Against Aspergillus Fumigatus

Horvat

Manz

et al. 2021

Advanced NanoBiomed Research

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Aspergillus fumigatus is the opportunistic fungus responsible for a variety of serious and often lethal diseases of immunocompromised patients, such as invasive aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis. Therapeutic options for such fungal infections are limited due to the high toxicity of currently available drugs. Herein, the potency of nanogels (NGs) is assessed for uptake and delivery of antifungal therapeutics. Therefore, poly(glycidol)‐based NGs are prepared by surfactant‐free inverse nanoprecipitation. Uptake studies conducted with fluorescently labeled particles demonstrate internalization by fungi in their hyphal form. In addition, loading with both amphiphilic and hydrophobic fluorescent dyes as model drugs show efficient delivery of the fluorescent dyes into the fungus. Finally, particles are loaded with the antifungal drug itraconazole by soaking lyophilized NGs in the drug solution (breathing‐in method). Efficient delivery of the drug by nanoprecipitated NGs, improved fungicidal activity, and reduced side effects as compared with the drug itself are shown.

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Promising Novel Nanopharmaceuticals for Improving Topical Antifungal Drug Delivery

Cited by 24 publications

References 86 publications

Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies

Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies

Application of Nanotechnology in Transdermal Drug Delivery

Nanogels as Antifungal‐Drug Delivery System Against Aspergillus Fumigatus

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