Microdermabrasion as a Novel Tool to Enhance Drug Delivery via the Skin: An Animal Study

Lee, William R.; Tsai, Ren‐Yeu; Fang, Chia‐Lang; Liu, Ching‐Ju; Hu, Chung‐Hong; Fang, Jia‐You

doi:10.1111/j.1524-4725.2006.32224.x

Cited by 44 publications

(38 citation statements)

References 25 publications

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“…Beside the chemical agents, a number of physical methods of surmounting the skin barrier are proposed to enhance the diffusion, including low-and high-intensity irradiation [130,158], fractional lamp [131,133] and laser [132] microablation, mechanical microperforation [137,138], ultrasonic (US) irradiation [134,135,159], electrophoresis [160], needleless injection [161], mechanical removal of the surface layer by means of abrasive paper [136], epidermal stripping [162], and microdermabrasion [163].…”

Section: Immersion Clearingmentioning

confidence: 99%

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Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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Section: Immersion Clearingmentioning

confidence: 99%

“…[163]. Microdermabrasion is a partial ablation and homogenisation of the epidermal stratum corneum under the action of high-pressure flow of microparticles.…”

Section: Immersion Clearingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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“…The depth of abrasion employed depends on the severity of the patient's skin condition, but in a clinical setting, the stratum corneum is not usually completely removed (6). Although initially designed for cosmetic applications, microdermabrasion has recently been used in several studies for delivery of small hydrophilic molecules, insulin, and vaccines (5,(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

“…In conventional use, microdermabrasion is a cosmetic procedure that improves the appearance of superficial skin defects such as fine lines, wrinkles, and scars by abrading the stratum corneum with pressurized particles (4)(5)(6)(7)(8)(9). The depth of abrasion employed depends on the severity of the patient's skin condition, but in a clinical setting, the stratum corneum is not usually completely removed (6).…”

Section: Introductionmentioning

confidence: 99%

Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion

2011

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Abstract. Microdermabrasion is widely used as a non-invasive cosmetic technique that has recently been adapted to selectively remove stratum corneum to increase skin permeability for transdermal drug delivery. This study measured the kinetics of skin barrier recovery after stratum corneum removal using microdermabrasion in hairless guinea pigs. The skin was abraded at two sites on each animal, one of which was allowed to recover under occlusion while the other remained non-occluded. Histological measurements showed that skin barrier properties to sulforhodamine B largely recovered within 12 h, and the stratum corneum appeared largely reformed within 24 h for both occluded and non-occluded skin. Skin electrical resistance measurements showed significant recovery of the skin barrier within 24 h. We conclude that transdermal drug delivery may occur for up to 12 h after microdermabrasion in guinea pigs; however, humans will probably have a longer recovery time due to expected slower skin healing rates.

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“…This includes microdermabrasion, chemical peeling, cosmetic emery boards, the use of wax strip, different sticky tapes, and salts. Microdermabrasion is more often used prior to laser treatment [29][30][31][32][33][34][35]. There are more than thirty chemical peels for dermatology and cosmetology, and more than ten of them are applied together with lasers [36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Optical clearing in photoacoustic flow cytometry

Menyaev

Nedosekin

Sarimollaoglu

et al. 2013

Biomed. Opt. Express

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Clinical applications of photoacoustic (PA) flow cytometry (PAFC) for detection of circulating tumor cells in deep blood vessels are hindered by laser beam scattering, that result in loss of PAFC sensitivity and resolution. We demonstrate biocompatible and rapid optical clearing (OC) of skin to minimize light scattering and thus, increase optical resolution and sensitivity of PAFC. OC effect was achieved in 20 min by sequent skin cleaning, microdermabrasion, and glycerol application enhanced by massage and sonophoresis. Using ~0.8 mm mouse skin layer over a blood vessel in vitro phantom we demonstrated 1.6-fold decrease in laser spot blurring accompanied by 1.6-fold increase in PA signal amplitude from blood background. As a result, peak rate for B16F10 melanoma cells in blood flow increased 1.7-fold. By using OC we also demonstrated the feasibility of PA contrast improvement for human hand veins.

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Microdermabrasion as a Novel Tool to Enhance Drug Delivery via the Skin: An Animal Study

Abstract: Microdermabrasion can improve the skin permeation of hydrophilic molecules.

Cited by 44 publications

References 25 publications

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion

Optical clearing in photoacoustic flow cytometry

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