Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review

Thoorens, Grégory; Krier, Fabrice; Leclercq, B.; Carlin, Brian; Évrard, Brigitte

doi:10.1016/j.ijpharm.2014.06.055

Cited by 439 publications

(274 citation statements)

References 66 publications

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“…SMCC which composed of 98 % microcrystalline cellulose had advantages in compressibility of microcrystalline cellulose. As a result, SMCC could improve the hardness of the A. crassna tablet [21]. Similar results were previously reported by Solaiman A [22,23].…”

Section: Effect Of Variables On Hardnesssupporting

confidence: 89%

“…Direct compression is the simplest and most cost-effective tablet manufacturing technique by which the tablets are directly compressed from a blend of ingredients without a preliminary granulation or agglomeration process [7,8]. Despite only a few steps in the manufacturing process, the product design in direct compression can be challenged due to some competing objectives [9].…”

Section: Introductionmentioning

confidence: 99%

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Study on Cause-Effect Relations and Optimization of Tablets Containing Aquilaria Crassna Spray-Dried Extract

Huong

Monsatta

Hanh

et al. 2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to develop and optimize the formulation of tablets containing Aquilaria crassna extract using the direct compression method.Methods: D-optimal design based on three independent variables was applied to evaluate the cause-effect relations and optimize the A. crassna tablet formulation. The weight variation (Y1), disintegration time (Y2), hardness (Y3) and friability (Y4) were investigated with respect to three independent variables including % dicalcium phosphate anhydrous (DCPA) in filler (X1), % filler (X2) and % croscarmellose sodium (CCNa) (X3). The dissolution study of the optimized A. crassna tablets were investigated in simulated gastric fluid (SGF) (pH 1.2) using a validated high-performance liquid chromatography (HPLC) method for mangiferin analysis.Results: All investigation factors were found to have significant effects on the physical properties of A. crassna tablet. The tablet hardness and the disintegration time increased in positive relations with the ratios of DCPA. The results exhibited the negative relations between disintegration time and the percentages of CCNa. The optimized A. crassna tablet formulation which included 35 % (w/w) DCPA in filler, 60 % (w/w) filler and 7% (w/w) CCNa possessed the weight variation of 1.38 % (w/w), the disintegration time of 6.29 min, the hardness of 85.63 N and the friability of 0.41 % (w/w). The optimized A. crassna tablet formulation was experimentally examined which demonstrated a good agreement between the experimental and predicted values. Mangiferin was found to release completely from the optimized A. crassna tablets within 30 min. Conclusion:The cause-effect relations and optimization of A. crassna tablet formulation were investigated and reported for the first time. The A. crassna spray-dried extract could be formulated into tablet by direct compression method with good mechanical properties and acceptable release profile.

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Section: Effect Of Variables On Hardnesssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Study on Cause-Effect Relations and Optimization of Tablets Containing Aquilaria Crassna Spray-Dried Extract

Huong

Monsatta

Hanh

et al. 2017

Int J Pharm Pharm Sci

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“…Cellulose type was shown to have a great influence on the resulting tablet properties (19)(20)(21). Vivapur 102 is a fine-grade microcrystalline cellulose and due to its anisometric particles and low density, its mass flow is lower compared to other diluents (22). Accordingly, in our case, powders with increased cellulose content also showed poorer flowability compared to formulations with higher lactose content.…”

Section: Evaluation Of Variables Affecting Powder Mixture Propertiesmentioning

confidence: 62%

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

Szabó

Székely-Szentmiklósi²,

Deák

et al. 2016

Acta Pharmaceutica

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Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental designTo evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be determined only by the characteristics of excipients. In order to test this assumption, both experimental designs were done with placebo mixtures. The optimized formulation was then evaluated both with and without APIs. Results indicated that filler and lubricant percentage, along with compression force, were the most important variables during the formulation study. The optimized formulation showed similar characteristics in both cases for all responses, except for angle of repose and friability where only minor differences were observed. The combination of the applied approaches (using placebo composition and fractional experimental design) proved to be efficient, cost effective and time saving.Keywords: design of experiments, optimization, factorial design, placebo formulation Proper management of hypertension, one of the leading causes of cardiovascular disease, is of the utmost importance. It has been established that lowering of blood pressure can effectively reduce the risk of cardiovascular events and stroke, but finding the most appropriate therapy is often difficult (1). Combinational therapies employing an angiotensin-converting enzyme inhibitor (ACEi) and indapamide (IND) offer the advantage of using two highly effective agents, increasing both clinical efficiency and patient compliance (2-4). Low dose combinations of ACEis and diuretics have shown greater reduction in blood pressure and higher success rates in managing hypertension than either of the treatments alone (4-6). The most popular ACEis present in these combinations include perin- Szabo et al.: Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design, Acta Pharm. 66 (2016) 191-206.

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“…Preparation of microcrystalline cellulose is generally used chemical processes by acid hydrolysis method, using a strong acid to remove amorphous part of cellulose to produce particles consisting of micro crystals. 3,4 However, chemical hydrolysis requires high activation energy and generates waste (acid, base, and organic compounds) which is less environmentally friendly. Current Research is being developed for a method of production of microcrystalline cellulose using cellulase enzymes.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Microcrystalline Cellulose from Water Hyacinth Powder by Enzymatic Hydrolysis Using Cellulase of Local Isolate

Suryadi¹,

Sutriyo²,

Sari³

et al. 2017

JYP

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Introduction: Microcrystalline cellulose is one of the cellulose derivatives widely used in the pharmaceutical industry as an excipient in the manufacture of tablets. Unfortunately, most of these filler materials are still largely imported. On the other hand, Indonesia has huge potential to generate microcrystalline cellulose from agricultural waste or weeds such as oil palm empty fruit bunch and water hyacinth. The purpose of this study was to find a potential cellulolytic mold and raw material for preparation of microcrystalline cellulose by enzymatic hydrolysis. Method: The potential cellulolytic mold was obtained from rotted oil palm trunk, and alpha cellulose was prepared by digesting raw material powder by the alkaline condition. Cellulase enzymes are obtained through extraction from the cellulolytic mold and used to treat alpha cellulose at a concentration of 2, 6 and 10 % v/v, respectively. Then, the resulted microcrystalline cellulose was identified by SEM (Scanning Electron Microscope) and XRD (X-Ray Diffraction) and compared with reference Avicel pH 101. Results: The results showed that crude enzyme of isolated mold has better activity than

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Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review

Cited by 439 publications

References 66 publications

Study on Cause-Effect Relations and Optimization of Tablets Containing Aquilaria Crassna Spray-Dried Extract

Study on Cause-Effect Relations and Optimization of Tablets Containing Aquilaria Crassna Spray-Dried Extract

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

Preparation of Microcrystalline Cellulose from Water Hyacinth Powder by Enzymatic Hydrolysis Using Cellulase of Local Isolate

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