Microbial Transformations of Steroids

Microorganisms as tools in modern chemistry: the biotransformation of 3-indolylacetonitrile and tryptamine by fungi

“…From the best of our knowledge, NMR data for compound 4 is not reported in the literature (6). Hydroxylation of an indole nucleus (3-indoleacetic acid) at C-5 by Aspergillus niger is reported (4).…”

“…Microorganisms can also be successfully used for pollutants degradation and recovery of the environment contaminated by chemicals (7). Their use for modifying the chemical structures of natural products is more recent but very well documented (4). However, the use of this methodology by the industry is still modest, considering the great availability of useful microorganisms and the large scope of useful reactions that can be accomplished by them.…”

Biotransformation of Indole Derivatives by Mycelial Cultures

“…Interestingly, when 3-indoleacetic acid was fed to Pseudomonas sp. (Kieslich, 1976) and 3-indolylacetonitrile was fed to Beauveria bassiana (Boaventura et al, 2004) 3-methyl-indole was also obtained. The fact that microorganisms can metabolize different indole derivatives to 3-methyl-indole suggests that the synthesis of this compound by using a biological reagent can be successfully addressed and even improved.…”

Wege zu neuen Enzymen: Protein Engineering und Katalytische Antikörper

“…Die Suche nach neuen Mikroorganismen, die aufgrund ihrer Lebensbedingungen ein gewunschtes Enzym produzieren konnten, ist der traditionelle Weg zu neuen Enzym-Akrivitaten [33]. Dieser Weg ist auch heute noch in der Praxis der wichtigste, weil die anderen Methoden erst viillig am Anfang stehen.…”