Microalgae: Fast-Growth Sustainable Green Factories

Forján, Eduardo; Navarro, Francisco; Cuaresma, María; Vaquero, Isabel; Ruíz-Domínguez, María C.; Gojkovic, Živan; Vázquez, María; Márquez, Mayca; Mogedas, Benito; Bermejo, Elizabeth; Girlich, Stephan; Domínguez, María José Tacoronte; Vílchez, Carlos; Vega, José M.; Garbayo, Inés

doi:10.1080/10643389.2014.966426

Cited by 64 publications

(44 citation statements)

References 195 publications

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“…The induction of algal cell lysis by viruses [3] and bacteria [4] is a well-known phenomenon and could provide a low-cost natural method for disrupting cell structures and so controlling microalgal growth. The recent interest in large-scale growth of microalga for the production of bulk and speciality chemicals, including biofuels, provides a further interest in developing low cost lysis methods which could be adapted for use in bioprocessing [5].…”

Section: Introductionmentioning

confidence: 99%

Characterisation of algicidal bacterial exometabolites against the lipid-accumulating diatom Skeletonema sp.

et al. 2016

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a b s t r a c t a r t i c l e i n f oMicroalgae are of increasing interest due to their occurrence in the environment as harmful algal blooms and as a source of biomass for the production of fine and bulk chemicals. A method for the low cost disruption of algal biomass for environmental remediation or bioprocessing is desirable. Naturally-occurring algal lytic agents from bacteria could provide a cost-effective and environmentally desirable solution. A screen for algal lytic agents against a range of marine microalgae has identified two strains of algicidal bacteria isolated from the coastal region of the Western English Channel. Both strains (designated EC-1 and EC-2) showed significant algicidal activity against Skeletonema sp. and were identified as members of Alteromonas sp. and Maribacter sp. respectively. Characterisation of the two bioactivities revealed that they are small extracellular metabolites displaying thermal and acid stability. Purification of the EC-1 activity to homogeneity and initial structural analysis has identified it as a putative peptide with a mass of 1266 amu.

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Section: Introductionmentioning

confidence: 99%

Characterisation of algicidal bacterial exometabolites against the lipid-accumulating diatom Skeletonema sp.

et al. 2016

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“…Suitable environmental and cultivation conditions to speed up biomass production are crucial for developing production processes that are efficient in costs and yield (Forján et al 2015). Large scale production of microalgae is challenging due to limitations to growth under harsh outdoor conditions.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic characterization and morphological and physiological aspects of a novel acidotolerant and halotolerant microalga Coccomyxa onubensis sp. nov. (Chlorophyta, Trebouxiophyceae)

et al. 2016

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“…This alga was grown in mineral liquid culture medium, at pH 2.5, in 5‐L batch reactors at 25°C, bubbled with air containing 5% (v/v) CO 2 , and continuously illuminated with white fluorescent lamps (Philips TL‐D 30W/54‐765 1SL; Philips Ibérica, SAU, Madrid, Spain), which supplies 165 μE m − 2 s −1 at the surface of the reactor. Stock cultures were maintained in Petri plates and prepared with 300 mL of 1.75% (w/v) agar solution and 700 mL of modified K9 medium, which were autoclaved separately and mixed before use (Forján et al ). Chlorella sorokiniana CCAP 211/8K (Shihira & Krauss ) was obtained from the UTEX culture collection, and it was grown using the method described by Cuaresma et al ().…”

Section: Methodsmentioning

confidence: 99%

“…In this context, a number of review articles have been published that highlight microalgae as effective antimicrobial producers (Plaza et al 2010;Najdenski et al 2013;Senhorinho et al 2015). In addition, microalgae have also been referred to as natural sources of high-quality proteins for foods and valuable molecules with applications in human healthcare, such as anti-inflammatory or antitumoral activity (Borowitzka 2013;Forján et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the acidophilic eukaryotic microalga Coccomyxa onubensis

Navarro

Forján

Vázquez

et al. 2016

Phycological Research

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SUMMARY Extremophilic microalgae are unexplored as a source of pharmaceuticals despite the fact that its biomass can be produced at large scale with low risk of contamination. A significant amount of antimicrobial activity was produced by extracts obtained from the eukaryotic acidophilic microalgae Coccomyxa onubensis in non‐polar solvents, such as hexane, diethyl ether, and chloroform or in weakly polar solvents, such as dichloromethane, against Gram‐negative and Gram‐positive bacteria, and also the yeast Candida albicans. The most effective activity was shown by chloroform extract against Escherichia coli S, Salmonella enterica, and Proteus mirabilis; hexane extract against P. mirabilis, Sa. enterica, and Ca. albicans; dichloromethane extract against Sa. enterica or diethyl ether extract against E. coli S and the Gram‐positive Staphylococcus aureus MB. The lowest minimum inhibitory concentration values were recorded against E. coli S (305 μg mL −1) and P. mirabilis (153 μg mL −1) (using chloroform extract) and against P. mirabilis (106 μg mL−1) (using hexane extract). Fatty acids, but not carotenoids, seem to be involved in the antimicrobial activity of this microalga. However, further biochemical and biotechnological studies must be conducted in order to characterize and purify the bioactive principles from Co. onubensis for assessing its potential as a pharmaceutical source and feasibility of production.

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Microalgae: Fast-Growth Sustainable Green Factories

Cited by 64 publications

References 195 publications

Characterisation of algicidal bacterial exometabolites against the lipid-accumulating diatom Skeletonema sp.

Characterisation of algicidal bacterial exometabolites against the lipid-accumulating diatom Skeletonema sp.

Phylogenetic characterization and morphological and physiological aspects of a novel acidotolerant and halotolerant microalga Coccomyxa onubensis sp. nov. (Chlorophyta, Trebouxiophyceae)

Antimicrobial activity of the acidophilic eukaryotic microalga Coccomyxa onubensis

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