Micro-electro-mechanical system–based drug delivery devices

Gupta, Ankur; Pal, Pramod

doi:10.1016/b978-0-08-102420-1.00010-8

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…Without invasive operations, implantable medication delivery pumps may enable externally controlled variable-rate distribution. Instead of relying on erosion or diffusion to release the medicine, pressure affects the delivery [ 140 ]. Implantable infusion pumps can be classified into two groups according to their pumping mechanisms: The first one is an osmotic or fluorocarbon propellant controlled passive pump and the latter one is the electrically powered active pump.…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

“…Implantable infusion pumps can be classified into two groups according to their pumping mechanisms: The first one is an osmotic or fluorocarbon propellant controlled passive pump and the latter one is the electrically powered active pump. MEMs-based infusion pumps are systems that provide a controllable drug release profile, an optimized drug action selectivity, and a decreased dosing frequency [ 140 ]. Implantable medication delivery pumps on ocular processing have made considerable strides recently, promising patients more independence and a better quality of life [ 141 ].…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

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Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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“…Along with micro-electro-mechanical system (MEMS) based drug delivery devices, flexible sensors are also playing a crucial role in the area of biomedical applications. Flexible sensors with wireless sensing modules are being developed in the biomedical field for the ease of end-user purposes [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Chemometric-Assisted Colorimetric-Based Inexpensive Paper Biosensor for Glucose Detection

2022

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This article reports a simple and inexpensive leak-proof paper pad with an initial selection of a paper substrate on the grounds of surface morphology and fluid absorption time. Herein, a drying method is used for glucose detection on a paper pad through colorimetric analysis, and the spot detection of glucose is analyzed by optimizing the HRP concentration and volume to obtain accurate results. The rapid colorimetric method for the detection of glucose on the paper pad was developed with a limit of detection (LOD) of 2.92 mmol L−1. Furthermore, the effects of the detection conditions were investigated and discussed comprehensively with the help of chemometric methods. Paper pads were developed for glucose detection with a range of 0.5–20 mM (apropos to the normal glucose level in the human body) and 0.1–0.5 M (to test the excessive intake of glucose). The developed concept has huge potential in the healthcare sector, and its extension could be envisioned to develop the reported paper pad as a point-of-care testing device for the initial screening of a variety of diseases.

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“…The rapid development of micro-electromechanical-system (MEMS) technologies has increasingly provided means to miniaturize and advance various biomedical devices and bio-MEMS [1][2][3][4]. The applications of these MEMS-based devices include cardiac devices [5,6], microneedles [7,8], lab-ona-chip devices for fast chemical/biological analysis [9][10][11], microsurgical robots [12][13][14][15][16], and in-vivo drug delivery systems for drug release with precision dosage and timing control [17][18][19][20]. MEMS actuators are widely used to realize these types of devices and enable accurate control of them [21].…”

Section: Introductionmentioning

confidence: 99%

MEMS actuators for biomedical applications: a review

Ghazali

Hasan

Rehman

et al. 2020

J. Micromech. Microeng.

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Micro-electromechanical-system (MEMS) based actuators, which transduce certain domains of energy into mechanical movements in the microscopic scale, are increasingly contributing to the areas of biomedical engineering and healthcare applications. They are enabling new functionalities in biomedical devices through their unique miniaturized features. An effective selection of a particular actuator, among a wide range of actuator types available in the MEMS field, needs to be made through the assessment of many factors involved in both the actuator itself and the target application. This paper presents an overview of the state-of-the-art MEMS actuators that have been developed for biomedical applications. The actuation methods, working principle, and imperative features of these actuators are discussed along with their specific applications. An emphasis of this review is placed on temperature-responsive, electromagnetic, piezoelectric, and fluid-driven actuators towards various application areas including lab-on-a-chip, drug delivery systems, cardiac devices and surgical tools. It also highlights the key issues of MEMS actuators in light of biomedical applications.

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Micro-electro-mechanical system–based drug delivery devices

Cited by 12 publications

References 48 publications

Application of Convergent Science and Technology toward Ocular Disease Treatment

Application of Convergent Science and Technology toward Ocular Disease Treatment

A Chemometric-Assisted Colorimetric-Based Inexpensive Paper Biosensor for Glucose Detection

MEMS actuators for biomedical applications: a review

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