Methods of Pain Assessment in Chicks as a Model

Naser, Ahmed; Albadrany, Yasser M.; Shaaban, K.A.

doi:10.21608/ejvs.2021.64605.1219

Cited by 9 publications

(9 citation statements)

References 42 publications

(62 reference statements)

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“…Holloway observed similarities in fibers and neurotransmitters when comparing the physiological response to pain receptors in chickens and mammals (18). The electric stimulus induces pain in chicks and avoidance that includes attempts to escape forcefully, represented by jumping and flapping wings (19). Electrical stimulation is used to generate pain and measure the occurrence of analgesia in chicks as a qualitative and quantitative method for measuring analgesia (20,21).…”

Section: Discussionmentioning

confidence: 99%

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Mohammed¹,

Albadrany²

2022

IJVS

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The study aimed to reveal pregabalin's median effective analgesic dose (ED50) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through ascending and descending in doses and depending on the up and down method, the median effective analgesic doses were determined for all drugs used in the study, and then the interaction experiment was conducted at a fixed ratio 0.5:0.5 of pregabalin with each of tramadol, diclofenac and paracetamol of their individual ED50 values, the results were subjected to the isobolographic analysis to determine the type of interaction. Results showed that ED50s for pregabalin, tramadol, diclofenac, and paracetamol in chicks were 156.5, 0.82, 5.65, and 10.74 mg/kg, respectively. Concomitant administration of drugs pregabalin: tramadol, pregabalin: diclofenac and pregabalin: paracetamol at a fixed ratio 0.5:0.5 of their individual ED50 values reduced their ED50s to 36.2:0.18, 64.3:2.3 and 64.3:4.3 mg/kg respectively. Isobolographic analysis showed synergistic analgesic effects of both drugs interaction. The calculated interaction indexes were 0.45, 0.81, and 0.81, respectively. We conclude from the outcomes that the analgesic interaction was synergistic between pregabalin and tramadol significantly, while the analgesic interaction of pregabalin with both diclofenac and paracetamol was also synergistic, but to a lesser extent.

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Section: Discussionmentioning

confidence: 99%

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Mohammed¹,

Albadrany²

2022

IJVS

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“…As for thermal stimulation by using the water bath test, it is an optimal model for stimulating thermal pain receptors. One of the limitations of our research is that we do not use mechanical stimulation because the device for stimulating mechanical pain receptors is not available (Foot pressure test) (20), and to confirm the analgesic effect of pain, a formalin test was used, which is one of the necessary acute pain tests that can be used in mice, rats, and chicks. The peak analgesic effect of lipoic acid was one hour after injection when using the water bath test.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Rehab

Naser

2022

IJVS

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Alpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain. The up and down method was used to calculate the median effect of the analgesic dose. The ED50 of ALA was 45.18 and 74.56 mg/kg intraperitoneally by electrical stimulation and hot water test, respectively. We demonstrated that the peak of analgesic effect was after one hour by using different doses and different times. ALA at 0, 75, 150, 300 mg/kg intraperitoneally produces a dose-dependent analgesic effect by formalin test. In conclusion: ALA induced analgesic activity, probably by closing voltage-gated calcium and or voltage-gated sodium channels. These outcomes show that therapeutic doses of ALA can affect pain and may mask or reduce nociception induced by acute pain models.

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“…Pain is an unpleasant sensory experience that is associated with actual or potential tissue damage. Pain measurement techniques that are both effective and accurate must be developed [1]. Although analgesia is an important part of veterinary medicine, the identification of pain in avian species remains difficult because of speciesspecific pain manifestations [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pain and Inflammation Protection Activities of Meloxicam in Chickens

Abdullah

Hadi

Albadrany

2023

Egyptian Journal of Veterinary Sciences

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T HIS study aimed to explore the pain and inflammation protective effects of meloxicam in chickens. Methods: The median lethal dose (LD 50 ) and median effective analgesic dose (ED 50 ) of intraperitoneally (i.p.) administered meloxicam were determined using an upand-down technique. Drug safety indices based on the collected results. The dose-dependent analgesic efficacy of meloxicam in chicks was determined by electrical stimulation. The formalin test was used to validate the pain and inflammation protective properties. Results: The median lethal dose (LD 50 ) was 156.5 mg/kg intraperitoneally. The median effective analgesic dose (ED 50 ) of meloxicam in chicks was 8.25 mg/kg intraperitoneally. Meloxicam's therapeutic index, standard safety margin, and therapeutic ratio when administered intraperitoneally, were 20, 0.4, and 6.7, respectively. Meloxicam's dose-dependent analgesic effect at 8 mg/kg and 16 mg/kg ip began 0.5 h after treatment and persisted for more than 4 hours. The analgesic effect of meloxicam peaked 2 h after intraperitoneal administration. Meloxicam induced a substantial increase in the latency to raise the right foot in the formalin test when compared to the control value, as well as a significant decrease in foot lifting frequency. The foot thickness decreased significantly compared to the control value. Conclusion: These findings indicate that meloxicam has pain and inflammation protective properties, which will serve as the foundation for future pharmacological investigations, and that this medicine may be safely administered to chickens.

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Methods of Pain Assessment in Chicks as a Model

Cited by 9 publications

References 42 publications

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Evaluation of Pain and Inflammation Protection Activities of Meloxicam in Chickens

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