Metabolomic fingerprinting of Cissampelos sympodialis Eichler leaf extract and correlation with its spasmolytic activity

Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

“…Plant extract and warifteine also decreased leukocyte migration into the airways and Th2 cytokine levels in lung tissue and bronchoalveolar lavage similar to dexamethasone [68] . In Melo et al .’s study, wariftein and methylwariftein ( 9 ) extracted from C. sympodialis had the effect of tracheal relaxation [7] …”

“…The results showed that warifteine may make contribution to muscle relaxation by inhibiting Ca 2+ channels and through modifying the intracellular Ca 2+ storage to be sensitive to noradrenaline [92] . Melo et al .’s study showed that methylwarifteine and warifteine mediated the spasmolytic activity from the extract of C. sympodialis leaves [7] …”

“…Many alkaloids such as bisbenzylisoquinolinic alkaloids isolated from the genus Cissampelos exhibited potent biological activities. Wariftein ( 8 ) and methylwariftein ( 9 ) extracted from C. sympodialis had the effect of tracheal relaxation [7] . Hayatinine ( 20 ) and cycleanine ( 14 ) isolated from C. pareira showed significant cytotoxic activity [8] …”

“…Wariftein (8) and methylwariftein (9) extracted from C. sympodialis had the effect of tracheal relaxation. [7] Hayatinine (20) and cycleanine (14) isolated from C. pareira showed significant cytotoxic activity. [8] Modern pharmacological studies show that the plants in Cissampelos genus have bronchodilator, antiinflammatory, cytotoxic, antimicrobial, anti-oxidant and antifertility activities, et al For instance, C. pareira Linn.…”

Warifteine Therapeutic Treatment Reduced Leukocyte Recruitment and Anxiety-Like Response in Ovalbumin-Induced Allergic Pulmonary Inflammation / Tratamento Terapêutico Com Warifteína Reduz Recrutamento De Leucócitos E Resposta Semelhante Á Ansiedade Na Inflamação Pulmonar Alérgica Induzida Por Ovalbumina

“…Medicinal plants and their bioactive molecules are alternatives to conventional therapies for many diseases. Cissampelos sympodialis Eichler (Menispermaceae) is an endemic species of Northeastern Brazil, whose leaves and roots are used in indigenous and popular medicine in the treatment of several inflammatory diseases, including asthma [19,20]. The bisbenzylisoquinoline alkaloid warifteine, isolated from C. sympodialis represents the major compound of the plant and its properties have been reported such as anti-inflammatory, anti-allergic, immunomodulatory and psychoactive in several experimental models [21][22][23][24][25][26][27][28][29][30][31].…”