Metabolism and health effects of phyto-estrogens

Nie, Qixing; Xing, Mengmeng; Hu, Jielun; Hu, Xiaojuan; Nie, Shaoping; Xie, Mingyong

doi:10.1080/10408398.2015.1077194

Cited by 29 publications

(15 citation statements)

References 219 publications

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“…Phytoestrogens are a group of plant-derived bioactive compounds that have estrogenic and anti-estrogenic effects due to their structures resembling estradiol [ 18 , 19 ] and they are also considered to be endocrine disruptors [ 20 ]. The two principal groups of phytoestrogens comprise lignans and isoflavones.…”

Section: Introductionmentioning

confidence: 99%

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

et al. 2020

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Current evidence on the relationship of phytoestrogens with sleep is limited and contradictory. In particular, studies on individual phytoestrogens and sleep have not been reported. Thus, this study aimed to appraise the associations of individual phytoestrogens with sleep disorders and sleep duration. This cross-sectional study comprising 4830 adults utilized data from the National Health and Nutrition Examination Survey 2005–2010. Phytoestrogens were tested in urine specimens. Sleep disorders and sleep duration were based on a self-reported doctor’s diagnosis and usual sleep duration. The main analyses utilized logistic and multinomial logistic regression models and a restricted cubic spline. In the fully adjusted model, compared with tertile 1 (lowest), the odds ratios (95% confidence intervals (CIs)) of sleep disorders for the highest tertile of urinary concentrations of enterolactone, enterodiol, and O-desmethylangolensin were 0.64 (0.41–1.00), 1.54 (1.07–2.21), and 1.89 (1.26–2.85), respectively. Linear inverse, approximatively linear positive, and inverted L-shaped concentration–response relationships were found between enterolactone, enterodiol, and O-desmethylangolensin and sleep disorders, respectively. Compared with normal sleep (7–8 h/night), the relative risk ratio (RRR) (95% CI) of very short sleep for enterolactone was 0.56 (0.36–0.86), and the RRR (95% CI) of long sleep risk for genistein was 0.62 (0.39–0.99). Furthermore, negative associations of genistein with sleep disorders and enterolactone with long sleep risk, as well as positive associations of enterodiol with both long and very short sleep, were observed in the stratified analysis by age or gender. Finally, a notable finding was that urinary O-desmethylangolensin concentration was positively related to sleep disorders in both females aged 40–59 years and non-Hispanic Whites but inversely associated with sleep disorders in both females aged 60 years or over and other Hispanics. Our findings suggested that enterolactone and genistein might be beneficial for preventing sleep disorders or non-normal sleep duration among adults, and enterodiol might be adverse toward this goal. However, the association of O-desmethylangolensin with sleep disorders might be discrepant in different races and females of different ages.

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Section: Introductionmentioning

confidence: 99%

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

et al. 2020

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“…Dietary and herbal approaches can be used as alternative medicines to slow the rate of bone loss. Many common foods contain naturally occurring bioactive molecules called phyto‐estrogens, which have potential roles in preventing bone resorption and enhancing bone formation . Various fruits, such as tomatoes (lycopene), dried plums, citrus fruits (flavonoids), berry fruits (phenolic acid and flavonoids), grapes (resveratrol), and apples (phloridzin), are rich in potent antioxidants, and these may have beneficial effects on bone health .…”

Section: Introductionmentioning

confidence: 99%

Effects of yuja peel extract and its flavanones on osteopenia in ovariectomized rats and osteoblast differentiation

Jeon

Lee

Kim

et al. 2016

Mol. Nutr. Food Res.

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“…Identification of novel phytoestrogens and characterization of their biological activities continues to be an area of active research (Nie et al, 2015). A thorough literature search reveals that many other phytosteroids exist and bind the progesterone, androgen, and corticoid receptors.…”

Section: Herbal and Dietary Effect On Fertilitymentioning

confidence: 99%

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Dean¹,

Murphy²,

Burdette³

2017

Molecular and Cellular Endocrinology

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Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids – chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4-[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements.

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Metabolism and health effects of phyto-estrogens

Cited by 29 publications

References 219 publications

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults

Effects of yuja peel extract and its flavanones on osteopenia in ovariectomized rats and osteoblast differentiation

Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

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