Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Dean, Matthew; Murphy, Brian T.; Burdette, Joanna E.

doi:10.1016/j.mce.2016.12.013

Cited by 46 publications

(36 citation statements)

References 99 publications

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“…1 . Compounds that increased reporter activity were genistein and daidzein, which are soy isoflavones, trans-oxyresveratrol, trans-resveratrol, and piceatannol, which are resveratrols, and trimethylapigenin, which is a flavone [9] . Because multiple soy isoflavones and resveratrols increased reporter activity, they were likely to be valid compounds.…”

Section: Resultsmentioning

confidence: 99%

Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Uchitomi

Nakai

Matsuda

et al. 2019

Biochemistry and Biophysics Reports

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PGC-1β is a transcriptional co-activator of nuclear receptors such as the estrogen receptor-related receptor (ERR). Transgenic overexpression of PGC-1β in mice increases energy expenditure and suppresses high-fat diet-induced obesity. In this study, we screened various food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β. Soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β. Genistein, daidzein, and trans-oxyresveratrol activated ERR-responsive element-mediated reporter activity in the presence of PGC-1β. Stable overexpression of PGC-1β in C2C12 myoblasts increased the expression of medium-chain acyl-CoA dehydrogenase (MCAD), an important enzyme in fatty acid β-oxidation. Genistein and daidzein increased MCAD mRNA levels and mitochondrial content in PGC-1β-expressing C2C12 cells. These compounds activated ERR/PGC-1β complex-mediated gene expression, and our findings may be a practical foundation for developing functional foods targeting obesity.

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Section: Resultsmentioning

confidence: 99%

Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Uchitomi

Nakai

Matsuda

et al. 2019

Biochemistry and Biophysics Reports

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“…In HeLa cells, kaempferol activated apoptosis elevating the Bax/Bcl-2 ratio [122]. Flavone apigenin also was reported to have estrogenic activity [123]. In PC-3 and DU145 cell lines apigenin induced Bax overexpression, the downregulation of Bcl-2 and Bcl-xL proteins, and stimulated cytochrome c release from mitochondria and subsequent activation of signaling cascades [124,125].…”

Section: Flavonoids In Apoptosismentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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“…This necessitates the search for novel harmless antiosteoporotic drugs. In line, phytochemicals could win wide recognition among the public and scientific community [ 10 ]. Extensive efforts have been made to reveal the beneficial effects of plants on bone health.…”

Section: Introductionmentioning

confidence: 99%

Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells

et al. 2017

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Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine compounds belonging to hydroxyphenylalkane and diarylheptanoid groups were isolated from Aframomum meleguea seeds and identified as 6-gingerol (1), 6-paradol (2), 8-dehydrogingerdione (3), 8-gingerol (4), dihydro-6-paradol (5), dihydrogingerenone A (6), dihydrogingerenone C (7), 1,7-bis(3,4-dihydroxy-5-methoxyphenyl)heptane-3,5-diyl diacetate (8), and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptane-3,5-diyl diacetate (9). The structures of isolated compounds were established by NMR and mass spectral data, in addition to referring to literature data. Exposure of MCF-7, MG-63, and SAOS-2 cells to subcytotoxic concentrations of the compounds under investigation resulted in accelerated proliferation. Among them, paradol was selected for further detailed biochemical analysis in SAOS-2 cells. DNA flowcytometric analysis of cell cycle distribution revealed that paradol did not induce any significant change in the proliferation index of SAOS-2 cells. Assessment of osteogenic gene expression revealed that paradol enhanced the expression of osteocyte and osteoblast-related genes and inhibited osteoclast and RUNX suppressor genes. Biochemically, paradol enhanced alkaline phosphatase activity and vitamin D content and decreased the osteoporotic marker acid phosphatase. In conclusion, paradol, which is a major constituents of A. melegueta seeds, exhibited potent proliferative and ossification characteristics in bone cells.

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Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products

Cited by 46 publications

References 99 publications

Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Flavonoids as Anticancer Agents

Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells

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