Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Uchitomi, Ran; Nakai, Shiho; Matsuda, Rintaro; Onishi, Takumi; Miura, Shinji; Hatazawa, Yukino; Kamei, Yasutomi

doi:10.1016/j.bbrep.2018.11.009

Cited by 15 publications

(14 citation statements)

References 11 publications

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“…and PGC-1β via the activation function 2 domains. 54,55 The similar results were observed in our present study ( Figure 6C). The pS2 has been also proved to a target gene of nERs and be associated with cell proliferation.…”

Section: Disscussionsupporting

confidence: 92%

Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study

Zhao

Zheng

et al. 2020

Environmental Toxicology

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Tamoxifen was widely applied in the therapy of estrogen receptor (ER)-positive breast cancer. With the purpose of determining the potential impacts of quercetin on its effectiveness, MCF-7 cells were selected as the in vitro model and several cellular biological behaviors (ie, cell proliferation, migration, invasion, cycle, apoptosis, and oxidative stress) were investigated. As results, quercetin showed contrasting doseresponse to cellular behaviors dependent on the ROS-regulated p53 signaling pathways. In detail, quercetin promoted cell proliferation and inhibited cell apoptosis at low concentrations, whereas high-concentration resulted in apoptosis induction. Moreover, quercetin at a low concentration significantly inhibited tamoxifen-induced antiproliferation in MCF-7 cells, whereas high concentrations enhanced cell apoptosis in a synergetic manner. The real-time quantitative polymerase chain reaction analysis further implied that quercetin exerted its dual roles in tamoxifen-induced antiproliferative effects by regulated the gene expression involved in cell metastasis, cycle, and apoptosis through the ER pathways. Our present study provides a considerable support to the combination of quercetin and tamoxifen on human ER-positive breast carcinoma management.

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Section: Disscussionsupporting

confidence: 92%

Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study

Zhao

Zheng

et al. 2020

Environmental Toxicology

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“…This leads to the upregulation of metabolic genes that promote mitochondrial biogenesis and activity [84]. Furthermore, genistein, a plant-derived compound, has recently been found to be an ESRRA agonist by small molecule screening [55,56,85], and improves diet-induced obesity by increasing energy expenditure, lipid catabolism via AMPK activation, and the serum TH concentration [86][87][88][89]. TH activates the PPARGC1A-ESRRA axis to increase mitochondrial biogenesis, activity, and turnover [62].…”

Section: Esrra As a Target For Obesitymentioning

confidence: 99%

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi

Yen

Singh

2020

IJMS

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The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism.ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

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“…It is well known that polyphenols and other bioactive compounds derived from plants may act on mitochondria. As an example, isoflavones, trans-resveratrol and resveratrol analogues, activate peroxisome proliferator—activated receptor γ (PPARγ) coactivator-1β (PGC-1β) leading to increase the levels of medium-chain acyl-CoA dehydrogenase, a mitochondrial enzyme that participates in lipid metabolism, in a transgenic model of PGC-1β overexpression [60]. The mode of action of these phytochemicals is unclear as PPARγ is a nuclear receptor and the upregulated enzyme is mitochondrial.…”

Section: Mitochondria-related Mechanisms Of Plant Antioxidant/nutrmentioning

confidence: 99%

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

2019

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Antioxidant action to afford a health benefit or increased well-being may not be directly exerted by quick reduction-oxidation (REDOX) reactions between the antioxidant and the pro-oxidant molecules in a living being. Furthermore, not all flavonoids or polyphenols derived from plants are beneficial. This paper aims at discussing the variety of mechanisms underlying the so-called “antioxidant” action. Apart from antioxidant direct mechanisms, indirect ones consisting of fueling and boosting innate detox routes should be considered. One of them, hormesis, involves upregulating enzymes that are needed in innate detox pathways and/or regulating the transcription of the so-called vitagenes. Moreover, there is evidence that some plant-derived compounds may have a direct role in events taking place in mitochondria, which is an organelle prone to oxidative stress if electron transport is faulty. Insights into the potential of molecules able to enter into the electron transport chain would require the determination of their reduction potential. Additionally, it is advisable to know both the oxidized and the reduced structures for each antioxidant candidate. These mechanisms and their related technical developments should help nutraceutical industry to select candidates that are efficacious in physiological conditions to prevent diseases or increase human health.

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Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression

Cited by 15 publications

References 11 publications

Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study

Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

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