Metabolic effects of combined oral contraceptives

Gillmer, M. D. G.

doi:10.1016/b978-0-407-01720-7.50006-0

Cited by 9 publications

(6 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypertension, venous thromboembolism and other cardiovascular disorders are potential side-effects of oral contraceptives which may be related to enhanced he patic action following exogenous sex steroid administra tion [1], Alterations in protein synthesis, coagulation fac tors and lipid metabolism are of obvious interest, but the precise mechanisms regulating these changes are poorly understood [2], Sex hormone action on liver metabolism is intimately related to pituitary function [3]. Growth hormone (GH) is a major regulatory hormone with pro found effects on protein, carbohydrate and lipid metab olism.…”

Section: Introductionmentioning

confidence: 99%

Altered Growth Hormone Secretion during Oral Contraception

Karlsson

Edén²,

Schoultz

1990

Gynecol Obstet Invest

View full text Add to dashboard Cite

Serum profiles of growth hormone (GH) were recorded for 24 h in 9 young healthy women before and during treatment with monophasic, combined contraceptives. During treatment, there was a change in GH secretion towards a pattern of smaller peaks at a higher frequency. The mean peak amplitude decreased from 11.2 to 7.3 mU/1, the mean peak area from 24.1 to 14.1 mU/1, and the mean interpeak interval from 4.3 to 3.0 h. The biological impact of altered GH secretion is well-known from animal experiments. A sex-steroid-induced change in GH secretion may be relevant for certain metabolic effects of oral contraceptives.

show abstract

Section: Introductionmentioning

confidence: 99%

Altered Growth Hormone Secretion during Oral Contraception

Karlsson

Edén²,

Schoultz

1990

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Not all wellcontrolled studies have reported these changes and the amplitude of such changes with low-dose OCs was often statistically insignificant while remaining within normal limits and was usually lower than with the older higher-dosed preparations [6][7][8][9][10][11][12]. Although specific changes of the hemostatic system can be identified in OC users (related to the EE dose and possibly modulated by the progestogen type and dose), none of the changes observed had been shown to be predictive of thromboembolic disease.…”

Section: Discussionmentioning

confidence: 67%

“…In healthy OC users without cardiovascular risk factors, the reported activation of pro-coagulation is usually compensated for by a similar activation ofpro-fibrinolysis, without disturbance of the hemodynamic equilibrium [6][7][8][9][10][11][12]. However, in moderate to heavy smokers, there are indications of a tendency towards pro-coagulability during long-term use of a combined OC preparation, whereas age did not appear to be a risk factor in this respect [8].…”

Section: Discussionmentioning

confidence: 68%

“…Although specific changes of the hemostatic system can be identified in OC users (related to the EE dose and possibly modulated by the progestogen type and dose), none of the changes observed had been shown to be predictive of thromboembolic disease. In addition, in healthy subjects there are no studies that have shown a causal relationship between a certain pro-coagulatory alteration in the hemostatic system and the development of a thrombus [7][8][9].…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

The effects of two phasic oral contraceptives on hemostasis and platelet function

et al. 1995

View full text Add to dashboard Cite

Objective." To compare the effects on hemostatic parameters of a combiphasic oral contraceptive containing desogestrel and ethinyl estradiol (DSG/EE) and a triphasic oral contraceptive containing levonorgestrel and ethinyl estradiol (LNG/EE). Methods:In an open-label, randomized, group-comparative study in 10 healthy volunteers per treatment group, the effects on parameters of coagulation, anticoagulafion, fibrinolysis, anfifibrinolysis and platelet function were determined at baseline, after three treatment cycles, and after a post-treatment cycle. Changes from baseline were analyzed using a paired t-test, whereas betweengroup differences were analyzed by means of an analysis of co-variance.Results: Both OC preparations induced modest changes of some coagulation, anticoagulation, fibrinolysis and antifibrinolysis parameters, although all mean values remained within the normal range. No significant effects were observed with either OC with respect to platelet function. Statistically significant differences between the two preparations could occasionally be observed: the concentrations of anfithrombin III (AT-III) and Factor VII were higher with the DSG/EE preparation than with the LNG/EE preparation at the end of treatment and AT-III activity, AT-III concentration, Factor X concentration, and plasminogen activity were higher with DSG/EE than with LNG/EE in the post-treatment cycle.Conclusions: Combiphasic DSG/EE and triphasic LNG/EE, both OCs with a comparable amount of EE per cycle, had no clinically significant effect on the overall hemostatic balance. 228Weinges et al.

show abstract

“…Dadurch konnten gewiinschte spezifische Partialwirkungen erzielt werden, wie bei den Antiandrogenen und ein unerwfinschter Einflug auf Stoffwechselparameter reduziert werden [6]. Dadurch konnten gewiinschte spezifische Partialwirkungen erzielt werden, wie bei den Antiandrogenen und ein unerwfinschter Einflug auf Stoffwechselparameter reduziert werden [6].…”

Section: W Braendleunclassified

Orale Kontrazeption — Nutzen und Risiken

Braendle¹

1995

Arch Gynecol Obstet

View full text Add to dashboard Cite

Metabolic effects of combined oral contraceptives

Cited by 9 publications

References 117 publications

Altered Growth Hormone Secretion during Oral Contraception

Altered Growth Hormone Secretion during Oral Contraception

The effects of two phasic oral contraceptives on hemostasis and platelet function

Orale Kontrazeption — Nutzen und Risiken

Contact Info

Product

Resources

About