Loss of immunoreactivity of human serum parathyroid hormone by the action of rat kidney enzyme, preferent-ia11y hydrolyzing parathyroid hormone. Horm.Res. 4: 213-218 (1973) &znl, I.M.: Distribution of labeled parathyroid hormone in rat fetus. Horm.Metab.Res. 4: 131-132 (1972) Yl'H-degradation activity in boiled matemal kidney (Table I) would indicate that the observed inactivation of PTH is an enzymatic process rather than due to loss of immunoreactivity by tissue binding.

No abstract

Serum levels of testosterone, LH and FSH were measured by radio•immunoassay in 215 male outpatients aged 15•83 years. Those with endocrine disorders, liver diseases or neo• plasms were excluded. Blood was drawn by venous puncture between 8 and 10 a.m. The results clearly demonstrate, that in males after the age of 50 years, a clear cut decrease of serum testosterone occurs (aged above 60 years: mean value 2.4 ng/ml; aged 20-30 years: mean value 3.5 ng/ml). Serum levels of LH are significantly higher when compared with younger men (9.5 to 5.3 mU/ml). There are also higher levels of FSH (14.5 to 11.1 mU/ml). The increase of LH (and perhaps of FSH) with increasing age points to the conditions in adolescence, where plasma levels of LH rise likewise. This increase, however, signals the maturation of the hypophyseal-gonadal axis, whereas in senility it demonstrates the gradual failure of the balanced interaction and is the hormonal correlate for the so called "male climacterium".

No abstract

The study was concerned with the comparison of the action profile of regular and NPH preparations of human insulin (recombinant DNA) and of PPI (pork purified insulin). In addition, the action profiles of some mixtures (10:90, 15:85, 20:80, 25:75, 30:70) of regular and NPH human insulin were evaluated. The comparisons were based on the Gerritzen test. There was no statistically significant difference in the time-course of the blood glucose levels after administration of NPH human insulin and NPH PPI. A tendency was noted, however, that NPH human insulin has a faster onset of action and that the serum glucose minimum for NPH human insulin lasts longer. The serum glucose curves after the application of regular and NPH human insulin initially lie closer together than after the respective PPI preparations. In the later phase, regular human insulin interferes less with the NPH curves. This means that combinations of regular and NPH human insulin may have a clinically useful action profile. No skin reaction or other adverse reaction was detected after application of human insulin and no antibodies against human insulin and Escherichia coli protein were found.