Serum Levels of FSH, LH and Testosterone in Human Males

Baier, Helmut; Bíró, G.; Weinges, K. F.

doi:10.1055/s-0028-1093800

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This more important increase in FSH suggests a decreased production of inhibin by the spermatogenetic cells. Most authors studying plasma gonadotrophin levels observed significant increases in both LH and FSH levels in elderly males (Greenblatt et al, 1976;Rubens et al, 1974;Stearns et al, 1974;Isurugi et al, 1974;Baier, Biro & Weinges, 1974), although Haug et al (1974) did not observe significant age dependent changes in basal serum gonadotrophin levels. These data point towards a primary testicular origin of the decreased androgen secretion.…”

mentioning

confidence: 97%

Decline in sexual activity in ageing men: correlation with sex hormone levels and testicular changes

Vermeulen

1979

J. Biosoc. Sci.

View full text Add to dashboard Cite

The menopause clearly marks the end of the reproductive phase in the female, but no comparable event of sudden discontinuity in fertility occurs in the male. Successful paternity in man has been recorded at the age of 94 (Seymour, Duffy & Koerner, 1935). This difference between the sexes is rather surprising, as the male does not seem to age in a fundamentally different way from the female and as, moreover, the death rate for males is higher in all age groups, than for females. This may be related to the presence of only one X chromosome, the eventual defects of which cannot be compensated for by the activity of the homologue. The Y chromosome does not appear to bear vital genes, as it is not essential for life, XO individuals being perfectly viable, in distinction to the YO genotype. Moreover in the absence of male inducers, the phenotype is female, suggesting that the male phenotype is a more complex differentiation. For whatever reason, the lower viability of the male remains a striking fact: males represent only 35% of the age group over 75 years. The persistence of reproductive function into old age is therefore the more surprising. This does not mean, however, that a gradual decrease in sexual activity and testicular function in the ageing male does not occur. From adolescence onwards, there is a continuous decline in sexual interest, arousal and activity, without a sudden discontinuity in any age group.If the frequency of orgasm is taken as a parameter (Fig. 1) it is found that at age 50 frequency has fallen to about 50% of what it was at age 30, and it approaches zero by age 75 (Bishop, 1970). It is remarkable that the slope of this curve does not show any abrupt change. An even more dramatic decline with age may be observed in the capacity for repeated orgasm. This reaches its peak in preadolescence, declining very rapidly after 20 years of age and in elderly males recovery may require 24 hr or even more (Harman, 1978). The quality of sexual activity also decreases with age: sexual arousal is slower and requires more intense stimuli, ejaculations are less forceful, detumescence after orgasm is quicker and the vasocongestive increase in testicular size during sexual excitement is decreased, as is the psychosexual pleasure. Frequency of erectal impotence increases exponentially with age: at 40, 50, 60 and 75 years respectively, about 2, 7, 28 and 50% of males are affected. A. Vermeulen3-5 r 3-0 2-5 I 2-0 1-5 1-0 0-5 Corrected meon Age groups (yeors) -70 -75 -80 -85

show abstract

mentioning

confidence: 97%

Decline in sexual activity in ageing men: correlation with sex hormone levels and testicular changes

Vermeulen

1979

J. Biosoc. Sci.

View full text Add to dashboard Cite

show abstract

“…However, individuals with the highest endogenous androgens are also the most likely to use AAS. The median age for first time AAS use (18 years of age [148]) correlates with peak serum testosterone levels in men [10]. The incidence of AAS use in young adult men is substantially greater compared to men with lower circulating androgen levels, including prepubertal boys and older men [148].…”

mentioning

confidence: 99%

Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

View full text Add to dashboard Cite

Anabolic-androgenic steroids (AAS) are drugs of abuse. They are taken in large quantities by athletes and others to increase performance, with negative health consequences. As a result, in 1991 testosterone and related AAS were declared controlled substances. However, the relative abuse and dependence liability of AAS have not been fully characterized. In humans, it is difficult to separate the direct psychoactive effects of AAS from reinforcement due to their systemic anabolic effects. However, using conditioned place preference and self-administration, studies in animals have demonstrated that AAS are reinforcing in a context where athletic performance is irrelevant. Furthermore, AAS share brain sites of action and neurotransmitter systems in common with other drugs of abuse. In particular, recent evidence links AAS with opioids. In humans, AAS abuse is associated with prescription opioid use. In animals, AAS overdose produces symptoms resembling opioid overdose, and AAS modify the activity of the endogenous opioid system. KeywordsAnabolic agents; Testosterone; self-administration; hamsters; drug dependence • Breakfast of champions: Recent history and prevalence of AAS useAnabolic-androgenic steroids (AAS) are a hot topic. A search of the Google news archive in March 2007 reveals 47,500 news stories on "steroids" in 2006, a 400% increase since their debut in the archive in 2002. In 2006, "steroids" even surpassed trend-setters such as "Paris Hilton" (38,500 stories) or "spinach" (42,700 stories). Current media attention on AAS abuse has been driven by accusations of steroid use among professional athletes in baseball, track, and cycling. However, public recognition of AAS use in sports dates back nearly 20 years, when Ben Johnson tested positive for stanozolol at the Seoul Olympics in 1988 [77]. Eastern Block athletes had been using steroids since the 1950's, and the International Olympic Committee banned steroid use from Olympic competition in 1976. However, the ability to reliably detect androgen metabolites in urine samples was limited until the advent of gas chromatography-mass spectroscopy [89]. Johnson's drug test spurred the United States Congress to pass the Anabolic Steroid Control Act of 1991 which declared steroids as Address all reprint requests and correspondence to Ruth I. Wood, Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo St., BMT 401, Los Angeles, CA 90033. Telephone (323) 442-1980, Fax: (323) 442-3466, e-mail: riw@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain....

show abstract

“…Both these patients also had high levels of FSH. It is not unexpected for patients in this age group to have elevated levels of LH and FSH (Baier, Biro and Weinges, 1974;Steams et al, 1974) but it is clear that it is of no prognostic importance with respect to treatment by orchidectomy. These measurements are analagous to Huggins' measurement of testicular weight and it is interesting to note that the three patients of Huggins (1942) who had small testes also had tumours that were undifferentiated.…”

Section: Discussionmentioning

confidence: 99%