Metabolic Concomitants of Obese and Nonobese Women With Features of Polycystic Ovarian Syndrome

Abstract

Context:Polycystic ovarian syndrome (PCOS) is often associated with obesity and diabetes.Objective:The present study measured body fat distribution and metabolic risk factors in women with features of PCOS.Design:Cross-sectional, multiethnic study of cardiovascular risks.Setting:General community.Study Participants:145 PCOS and 344 non-PCOS women.Exposure Measures:Body composition by dual x-ray absorptiometry; abdominal fat masses measured by magnetic resonance imaging and hepatic triglyceride by magnetic resonance spectroscopy.Outcomes Measures:Body composition, liver fat content, homeostatic model assessment for insulin resistance (HOMA-IR), revised, and metabolic syndrome components.Results:PCOS women had a higher free androgen index compared with the non-PCOS women. Nonobese PCOS and non-PCOS women had a similar body fat content and distribution, HOMA-IR, and hepatic triglyceride content. Obese PCOS women had a similar total body fat percentage compared with their non-PCOS counterparts (41.4% and 41.4% respectively). Both obese groups had similar intraperitoneal fat (1.4% of total body mass in PCOS vs 1.4% in non-PCOS). However, obese PCOS women had a greater ratio of truncal/lower body fat (1.42 vs 1.27; P < 0.016). They also had greater insulin resistance (HOMA-IR: PCOS, 2.24% vs non-PCOS, 1.91%; P < 0.016), higher liver triglyceride content (6.96% in PCOS vs 4.44% in non-PCOS; P < 0.016), and a greater incidence of hypertension (33% vs 24%; P < 0.05). No differences were observed in other metabolic risk factors.Conclusions:Both obese and nonobese women with PCOS features had a greater free androgen index compared with non-PCOS women, but neither had greater intraperitoneal fat or abnormal lipid levels. Obese, but not nonobese, women with PCOS had a greater truncal/lower extremity fat ratio, HOMA-IR, and liver triglyceride content.

A Community Based Cross Sectional Study on Prevalence Of Polycystic Ovarian Syndrome (PCOS) and Health Related Quality of Life in Pakistani Females

“…As substantiated by the diagnostic literature on PCOS, the most commonly reported presentation of symptoms was ovulatory malfunction, hyperandrogenism, and polycystic ovarian morphology (PCOM) (21). The metablic features of this condition include predominantly, an abnormality in fat distribution (22). In terms of health status, we found out that the participants who reported high prevalence of clinical features of PCOS had poor health related quality of life on all domains of SF-36.…”

Obese and non-obese polycystic ovarian syndrome: Comparison of clinical, metabolic, hormonal parameters, and their differential response to clomiphene

“…Other features that have been associated with PCOS include insulin resistance (IR) and metabolic syndrome. [3]…”

ACC/AHA 2017 definition of high blood pressure: implications for women with polycystic ovary syndrome

“…W omen with polycystic ovary syndrome (PCOS) face increased cardiovascular risk when compared with healthy women of the same age. Polycystic ovary syndrome, otherwise characterized by an association between hyperandrogenism and ovulatory dysfunction, is also often associated with obesity (1,2), lipid abnormalities (3,4), insulin resistance (IR) (5), and high blood pressure/systemic arterial hypertension (SAH) (6)(7)(8). The mechanism underlying the increased prevalence of SAH in PCOS has been linked to a series of factors such as obesity in and of itself (9), heart autonomic dysfunction (10)(11)(12), hyperandrogenism (13,14), and IR (15).…”