1962
DOI: 10.1210/endo-71-2-221
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Metabolic and Anti-inflammatory Properties of 6-Methyl Prednisolone Alone and in Combination with Anabolic Hormones

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Cited by 13 publications
(2 citation statements)
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“…A rough etidoplasmic reticulum is usually assoeiated with cells which are actively synthesizing proteins for export (Ross 1968). Adrenalcorticoid hormones have been shown to inhibit the biosynthesis of collagen as well as other proteins (Bavetta et al 1962, Nimni & Bavetta 1964. The biochemical block tnay lie at the level of the m-RNA-r-RNA* cotnplex sinee steroids cause a reduction in the total amount of particulate RNA (Gabourel & Fox 1965).…”
Section: Ribosotnal Evetitsmentioning
confidence: 99%
“…A rough etidoplasmic reticulum is usually assoeiated with cells which are actively synthesizing proteins for export (Ross 1968). Adrenalcorticoid hormones have been shown to inhibit the biosynthesis of collagen as well as other proteins (Bavetta et al 1962, Nimni & Bavetta 1964. The biochemical block tnay lie at the level of the m-RNA-r-RNA* cotnplex sinee steroids cause a reduction in the total amount of particulate RNA (Gabourel & Fox 1965).…”
Section: Ribosotnal Evetitsmentioning
confidence: 99%
“…This can be illustrated particularly well using the example of the synthetic glucocorticoid methylprednisolone, which exhibits reduced MR affinity and multiplied glucocorticoid potency compared with its unmethylated derivative, prednisolone. Methylprednisolone, also known as medrol, is applied for the treatment of arthritis and other inflammatory diseases and thus, highly appreciated by the pharmaceutical industry (Bavetta, Bekhor, Shah, O'Day, & Nimni, ). The increasing demand of this compound requires the development of production strategies, that are aimed at achieving high‐product yields while maintaining the cost‐effectiveness of the process.…”
Section: Introductionmentioning
confidence: 99%