The effect of various anti‐inflammatory drugs on the accumulation of leucocytes in the peritoneal cavity of mice

Northover, B. J.

doi:10.1002/path.1700880148

Cited by 16 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhibition of leucocyle tiiigration by exogenously administered steroids has also been reported by Boggs p/a/, (1964) and by Slonecker and Lim (1972). However, contrary to the finditigs above, the work of Northover (1963Northover ( . 1964 suggests that the effects of steroids on leucocyte tnigration are not directly due to an effect on vascular permeability.…”

Section: Discussionmentioning

confidence: 62%

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

Bassett

Tait

1981

Aust J Exp Biol Med

View full text Add to dashboard Cite

Summary. Although previous studies have shown ihal Ihe injection of exogenous corliccsteroids suppresses the infliimmatory response, no study has been made on the effecl on inflammation of endoeenous cortieosieroids released in response to stress, [n the present study ;i reduction was observed in the total number of leucocytes migtaling into the peritoneal cavity of stressed rats in response to the injection of an inllammalary agent. The reduction in tolal counts was due to & stress-induced reduction of both polymorph and mononuclear cells. Permeability studies iind blood leucocyte counts were conducted to deiermine the mode of action of the stress induced reduction of leucocyte migr.ition. In ihe case of the polymorphs. evidence is presented lo implicate both a reduced release of these cells into the blood stream from storage sites and a blockade of the increased vascular permeability. The situation is not as clear for the mononuclear cells where no change in the circulating levels of these cells was observed in either stressed or control rats following induction of an inflammatory response.

show abstract

Section: Discussionmentioning

confidence: 62%

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

Bassett

Tait

1981

Aust J Exp Biol Med

View full text Add to dashboard Cite

show abstract

“…The anti-inflammatory effects of glucocorticoid hormones have been well documented in mammals (Bogg et al, 1964;Northover, 1964;Thompson & Van Furth, 1970). In fish, studies have been made of the effects on circulating blood leucocyte numbers (Weinreb, 1958), chemical and surgically-induced inflammation (Weinreb, 1959) the antibody response (Anderson et al, 1982), serum components (White & Fletcher, 1982), and the susceptibility to fungal and bacterial infection (Pickering & Duston, 1983).…”

Section: J I M a C A R T H U R E T 4 Lmentioning

confidence: 99%

Peritoneal inflammatory cells in plaice, Pleuronectes platessa L.: effects of stress and endotoxin

MacArthur

Fletcher

Pirie

et al. 1984

Journal of Fish Biology

View full text Add to dashboard Cite

When plaice were injected intrapentoneally with either oyster glycogen or live Vibrio algino/yticus an acute cellular inflammatory response was observed. The duration of these responses, 7 and 15 days respectively, exceeded the time course of the mammalian cellular inflammatory reaction. Peak leucocyte numbers were found at 2-3 days and neutrophils, which were phagocytic, were more numerous than macrophages. Although the increase in macrophage numbers was less marked, these cells appeared more actively phagocytic than neutrophils. Cortisol injections and environmentally-induced stress caused a significant reduction in the extent of inflammatory cell infiltrates, while endotoxin significantly enhanced the response.

show abstract

“…acetic acid and 0.1 per cent. gentian violet (Northover, 1964); a portion was placed in a haemacytometer chamber and the total number of leucocytes in 0.1 p1. counted.…”

Section: Ratsmentioning

confidence: 99%

The mononuclear response to intrapleural injection in the rat

1966

View full text Add to dashboard Cite

THAT an infiltrate initially composed of polymorphs is transformed to an accumulation of mononuclear cells is a well established but poorly understood aspect of the acute inflammatory reaction. For many years this change in the cell population of an inflamed area has been explained by later migration of mononuclears than polymorphs from vessels, and coupled with a relatively short period of survival of polymorphs in extravascular tissue.Recently Paz and Spector (1962), after studying the cellular response to intradermal injection of fibrinogen and other solutions into rats, put forward an alternative hypothesis : simultaneous migration of polymorphs and mononuclears followed by rapid disappearance of the former but not of the latter type of cell. Under this hypothesis one substance could mediate the escape of all leucocytes in inflammation, whereas the older concept implied independent mediators for each type of cell.

show abstract

The effect of various anti‐inflammatory drugs on the accumulation of leucocytes in the peritoneal cavity of mice

Cited by 16 publications

References 14 publications

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

Peritoneal inflammatory cells in plaice, Pleuronectes platessa L.: effects of stress and endotoxin

The mononuclear response to intrapleural injection in the rat

Contact Info

Product

Resources

About