Meta-analysis of randomized, controlled trials comparing griseofulvin and terbinafine in the treatment of tinea capitis

Tey, Hong Liang; Tan, Andy S.L.; Chan, Yuin‐Chew

doi:10.1016/j.jaad.2010.02.048

Cited by 71 publications

(46 citation statements)

References 17 publications

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“…Terbinafine was the only agent to have a higher complete cure rate of 92% [16]. However, griseofulvin was superior in treating infections caused by Microsporum species [16, 17]. Hence, longer courses of griseofulvin sometimes were required to cure infections caused by M. canis [1].…”

Section: Griseofulvinmentioning

confidence: 99%

“…Laboratory monitoring for courses longer than 6 weeks may be required [36]. Most clinical trials have demonstrated a 4-week course of once-a-day dose to be effective in treating tinea capitis [17]. The duration of this course is significantly shorter than that of griseofulvin.…”

Section: Terbinafinementioning

confidence: 99%

“…Multiple meta-analyses have demonstrated a similar efficacy for a 6-week course of griseofulvin and a 4-week course of terbinafine [17, 36, 39]. However, a difference in efficacy was found based on the infectious organism.…”

Section: Terbinafinementioning

confidence: 99%

See 2 more Smart Citations

Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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Tinea capitis is a common fungal infection of the hair of the scalp affecting predominately prepubertal children. In the US, griseofulvin has been considered a first-line therapy agent for tinea capitis since the 1960s. However, it has been falling out of favor due to significant treatment failure, high cost, and long duration of treatment. Other antifungal agents have been researched as an alternative to griseofulvin. This paper will review the relevant pharmacologic properties, dosing, cost, efficacy, and adverse events profile for griseofulvin, terbinafine, itraconazole, fluconazole, and some adjuvant therapy options such as selenium sulfide shampoos and topical ketoconazole.

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Section: Griseofulvinmentioning

confidence: 99%

Section: Terbinafinementioning

confidence: 99%

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Treatment of Tinea Capitis

Alkeswani

Cantrell²,

Elewski

2019

Skin Appendage Disord

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show abstract

“…The mycological classification of tinea capitis correlates to the genera of the etiological agents: Microsporum in ectothrix, with hyphae parasitizing the hair on its surface, and Trichophyton in endothrix, where hyphae are presented inside the hair shaft . It is known that griseofulvin is best indicated to treat infections by Microsporum and terbinafine to those caused by Trichophyton …”

Section: Case Reportmentioning

confidence: 99%

Reflectance confocal microscopy of tinea capitis: comparing images with results of dermoscopy and mycological exams

Veasey¹,

Meneses

Silva

2018

Int J Dermatology

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“…Le but du traitement est de guérir le patient, d'éviter la contagion, de diminuer le retentissement psychologique d'une teigne sur l'enfant et sur son entourage et d'éviter, dans le cas du favus, une alopécie cicatricielle définitive. [31][32][33]. La durée du traitement pourrait être prolongée de 3 à 4 mois en cas de teigne ectothrix à Microsporum sp.…”

Section: Traitementunclassified