Meta-analysis indicates that resistant starch lowers serum total cholesterol and low-density cholesterol

Yuan, Haitao; Yue, Meng; Bai, Hao; Shen, Deqiang; Wan, Bing; Chen, L.Y.

doi:10.1016/j.nutres.2018.02.008

Cited by 49 publications

(37 citation statements)

References 44 publications

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“…Overall studies showed that RS intake did not affect HDL-C and TG compared with the control groups and LDL did not reveal significant heterogeneity among the trials 47 . In our study, baseline HDL-C was lower in green banana biomass group compared with controls, and remained lower after the intervention.…”

Section: Discussionmentioning

confidence: 88%

“…Previous studies reported the effects of RS on glucose metabolism, anthropometric parameters and serum cholesterol levels in animal models, healthy or diabetic humans 4 , 9 , 47 , 48 . Some controversies in the results may be due to differences in the pathologic state of the subjects, source, dose and type of RS, diet composition, total dietary fiber intake and dietary RS content 49 .…”

Section: Discussionmentioning

confidence: 99%

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Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Lotfollahi

Mello

Costa

et al. 2020

Sci Rep

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The aim of this study was to investigate the effects of 6-months consumption of green-banana biomass on the LDL particle functionality in subjects with type 2 diabetes. Subjects (n = 39, mean age 65 years old) of both sexes with diabetes (HbA1c ≥ 6·5%) were randomized to receive nutritional support plus green-banana biomass (40 g) (n = 21) or diet alone (n = 18) for 6-months. Non-linear optical responses of LDL solutions from these participants were studied by Z-scan technique. UV–visible spectrophotometer was used to measure the absorbance of the LDL samples. Small Angle X-ray Scattering and Dynamic Light Scattering experiments were used to look for any structural changes in LDL samples and to determine their size distribution. The Lipoprint test was used to determine the LDL sub-fractions in terms of distribution and size. Consumption of green-banana biomass, reduced total- ( p = 0.010), non-HDL-cholesterol ( p = 0.043), glucose ( p = 0.028) and HbA1c ( p = 0.0007), and also improved the protection of the LDL particle against oxidation, by the increase in carotenoids content in the particles ( p = 0.007). This higher protection against modifications may decrease the risk of developing cardiovascular disease. These benefits of the green-banana biomass encourage the use of resistant starches with potential clinical applications in individuals with pre-diabetes and diabetes.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Lotfollahi

Mello

Costa

et al. 2020

Sci Rep

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“…However, we found significant increase in HDL-C after the intervention with 13.5 g/day resistant starch. This lack of effect in study by Kwak et al [12] might be explained by the fact that the lipid-lowering effects of resistant starch may be dependent upon high levels of intake [26]. In our study the beneficial effect of resistant starch on HDL-C could be through decreasing the dietary cholesterol absorption in the intestine, increasing of faecal cholesterol excretion, and increasing the production of SCFA via gut microbiota fermentation, in particular, propionate and butyrate, which may inhibit of hepatic cholesterol synthesis [7].…”

Section: Discussionmentioning

confidence: 99%

Effects of Resistant Starch Supplementation on Glucose Metabolism, Lipid Profile, Lipid Peroxidation Marker, and Oxidative Stress in Overweight and Obese Adults: Randomized, Double-Blind, Crossover Trial

et al. 2019

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Obesity is a substantial public health challenge across the globe. The use of resistant starch has been proposed as a probable management strategy for complications of obesity. We investigated the effects of resistant starch intake on lipid profiles, glucose metabolism, antioxidant status, lipid peroxidation marker, blood pressure, and anthropometric variables in subjects with overweight or obesity. In this 12-week, randomized, double-blind, placebocontrolled, 2 × 2 crossover trial, 21 Participants (mean age, 35 ± 7.0 years; body mass index, 32.4 ± 3.5 kg/m 2 ) were given 13.5 g Hi-Maize 260 or placebo daily for 4 weeks, separated by a 4-week washout period. Changes in total antioxidant status (p = 0.04) and serum concentrations of insulin in 52.4% participants with insulin levels above 16 µIU/mL at the baseline (p = 0.04) were significantly different in the three phases. In addition, the mean of serum high-density lipoprotein cholesterol after the intervention was significantly higher than after baseline value (p = 0.04). We found no significant differences in serum concentrations of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, homeostatic model assessment of insulin resistance, quantitative insulin sensitivity check index, superoxide dismutase activity, malondialdehyde, blood pressure, and anthropometric variables in the three phases of baseline, after intervention with resistant starch and after placebo. Resistant starch consumption improved serum insulin concentrations, lipid profiles, and antioxidant status in subjects with overweight or obesity.

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“…The main health outcomes of RS consumption can be categorized mainly based on a modulation on the glycemic response, body weight control, and bowel health. However, this review is not intended, by any means, to provide deep insights into the complex effects of RS consumption on specific metabolic responses and health benefits, which has been previously revised elsewhere [5,14,15,16,17,18,19,20,21,22,23,24,25,26,27].…”

Section: Rs Definition and Analytical Methodsmentioning

confidence: 99%

Structural Basis of Resistant Starch (RS) in Bread: Natural and Commercial Alternatives

Román

Martínez

2019

Foods

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Bread is categorized as having a high amount of rapidly digested starch that may result in a rapid increase in postprandial blood glucose and, therefore, poor health outcomes. This is mostly the result of the complete gelatinization that starch undergoes during baking. The inclusion of resistant starch (RS) ingredients in bread formulas is gaining prominence, especially with the current positive health outcomes attributed to RS and the apparition of novel RS ingredients in the market. However, many RS ingredients contain RS structures that do not resist baking and, therefore, are not suitable to result in a meaningful RS increase in the final product. In this review, the structural factors for the resistance to digestion and hydrothermal processing of RS ingredients are reviewed, and the definition of each RS subtype is expanded to account for novel non-digestible structures recently reported. Moreover, the current in vitro digestion methods used to measure RS content are critically discussed with a view of highlighting the importance of having a harmonized method to determine the optimum RS type and inclusion levels for bread-making.

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Meta-analysis indicates that resistant starch lowers serum total cholesterol and low-density cholesterol

Cited by 49 publications

References 44 publications

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

Effects of Resistant Starch Supplementation on Glucose Metabolism, Lipid Profile, Lipid Peroxidation Marker, and Oxidative Stress in Overweight and Obese Adults: Randomized, Double-Blind, Crossover Trial

Structural Basis of Resistant Starch (RS) in Bread: Natural and Commercial Alternatives

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