Mesua ferrea L.: A review of the medical evidence for its phytochemistry and pharmacological actions

Objectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC50 of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. Conclusions. P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.

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“…To treat snakebites [8] Analgesic and antibacterial activities [30] Hesperethusa crenulata (Roxb.) Roem.…”

Section: Guntgaw Calophyllaceae L 12mentioning

confidence: 99%

Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Zhang

Arunachalam

Wang

et al. 2021

The Scientific World Journal

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“…The crystal structure of the 3CL pro /M pro COVID-19 (PDB ID: 6LU7) was downloaded from the Protein Data Bank (PDB) (Berman et al, 2000). The small molecules of Mesua ferrea Linn are selected from literature (Table 1) (Chahar, 2013;Sharma et al, 2017) and all 3D structures of the ligands except Mesuabixanthone-A and -B, were obtained from PubChem Open Chemistry Database (Kim et al, 2019). The 3D structures of Mesuabixanthone-A and -B were obtain from ChemDraw professional 17.1.…”

Section: Data Collection Tools (3d Structure Of the Ligands And Receptor)mentioning

confidence: 99%

Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest

Saddiqa¹,

Çakmak²,

Usman

et al. 2021

Turkish Journal of Science and Health

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The coronavirus, known as severe acute respiratory syndrome (SARS-CoV-2), is accountable for the global epidemic disease COVID-19. The effective treatment of this disease is still unknown and there is an emergent need to use all resources to find the effective medication. The use of off-label natural medicinal compounds may be effective remedy for this scourge. For this reason, it was aimed to investigate the theoretical effect of Mesua ferrea Linn, an Asian medicinal plant, against COVID-19 disease. Material and Methods: In silico studies, molecular docking was performed using AutoDock Tools (ADT) version 1.5.6 package, and the coupling processes were performed using AutoDock 4.2 package. Results: Towards the investigation of effective inhibitor of 3CL protease, we studied the in silico interaction of the selected compounds of Mesua ferrea Linn. The studied compounds have shown significant inhibition properties. The timber extracts, Mesuabixanthone-B (∆Gbind = -15.51 kcal/mol) and Mesuferrol-B (∆Gbind = -14.32 kcal/mol) have the exciting impact on 6LU7. Conclusion:The in silico prediction of toxicities of the extracts are promising. The further lab research is necessary to identify their drug candidate capabilites against COVID-19 infections.

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“…This plant species showed a wide range of various phytochemical constituents, including coumarins, xanthones, triterpenoids, anthraquinones and flavonoids [16][17][18][19][20]. The plant has shown various pharmacological activities including anti-oxidant, anti-spasmodic, anti-inflammatory, anti-cancer, anti-ulcer, anti-diabetic, antiarthritic, anti-microbial, anti-venom, anti-convulsant, anti-hemorrhoid, central nervous system depressant, α-amylase inhibitory, immunomodulatory and hormone balancing, hepatoprotective, analgesic, and diuretic activities [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

et al. 2021

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Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus). The results indicated that the M. ferrea flower extract could be considered as the bactericidal agent against S. epidermidis and S. aureus with MIC values of 0.78 and 6.25 mg mL−1 and MBC values of 1.56 and 12.50 mg mL−1 and the bacteriostatic agent against C. acnes with MIC and MBC values of 3.12 and 25.00 mg mL−1, respectively. The extract at a concentration of 25 µg mL−1 also presented potent anti-inflammatory activity with a significant decrease of nitric oxide (NO) and tumor necrosis factor (TNF)-α productions in RAW 264.7 macrophage cells stimulated by LPS. In addition, the extract showed moderate to weak anti-oxidative capacities against DPPH, ABTS, FRAP and NO assays and also showed weak anti-tyrosinase activity. M. ferrea flower extract may serve as the alternative natural anti-acne formulations.

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Mesua ferrea L.: A review of the medical evidence for its phytochemistry and pharmacological actions

Cited by 28 publications

References 39 publications

Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest

Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

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