Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

Nakyai, Wongnapa; Pabuprapap, Wachirachai; Sroimee, Wichuda; Ajavakom, Vachiraporn; Yingyongnarongkul, Boon‐ek; Suksamrarn, Apichart

doi:10.3390/cosmetics8040107

Cited by 16 publications

(14 citation statements)

References 54 publications

(59 reference statements)

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“…In our study of the efficacy of the ethyl acetate black ginger extract, a group of volunteers using CKP exhibited a decrease in acne spots and inflammation. The inflammatory mechanism of acne can be triggered by pathogenetic bacteria including C. acnes , S. epidermidis, and S. aureus [ 2 , 3 ]. C. acnes , a predominant bacterium in hair follicles, is a factor in acne vulgaris and inflammation that triggers proinflammatory cytokines, such as IL-8, IL-12, IL-1α, IL-1β, and TNF-α, in human keratinocytes, sebocytes, and microphages through toll-like receptor-2 (TLR-2), which induces the NF-κB pathway.…”

Section: Discussionmentioning

confidence: 99%

“…It stimulates the secretion of free radicals and inflammatory mediators, such as nitric oxide (NO), and proinflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-8 (IL-8), and tumor necrosis factor (TNF-α), through toll-like receptor 2 (TLR-2). These proinflammatory cytokines can promote the development of inflammation in the skin and acne [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Kaempferia parviflora Rhizome Extract as Potential Anti-Acne Ingredient

et al. 2022

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Kaempferia parviflora (Black ginger) is used widely in medical fields as an anti-microorganism and anti-inflammation. In this study, the aim was to evaluate the in vitro and in vivo anti-acne efficacy of black ginger extract. The results indicate that the methanol and ethanol extracts showed the highest total phenolic contents, without a significant difference, whereas the n-hexane extract showed the highest total flavonoid content. Nine flavones were detected using UPLC−QTOF−MS, and the ethyl acetate extract showed the highest amount of 5,7-dimethoxyflavone (DMF) according to HPLC. Antibacterial activity against Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes was observed. All the extracts showed antimicrobial activity against C. acnes, revealing MICs in the range of 0.015 to 0.030 mg/mL, whereas the ethyl acetate extract inhibited the growth of S. epidermidis with a MIC of 3.84 mg/mL. In addition, the ethyl acetate extract showed the highest activity regarding nitric oxide inhibition (IC50 = 12.59 ± 0.35 µg/mL). The ethyl acetate extract was shown to be safe regarding cell viability at 0.1 mg/mL. The anti-acne efficacy was evaluated on volunteers. The volunteers were treated in two groups: one administered a 0.02% ethyl acetate extract gel-cream (n = 9) and one administered a placebo (n = 9) for 6 weeks. The group treated with the gel-cream containing the extract showed 36.52 and 52.20% decreases in acne severity index (ASI) after 4 and 6 weeks, respectively, and 18.19 and 18.54% decreases in erythema, respectively. The results suggest that K. parviflora could be a potent active ingredient in anti-inflammatory and anti-acne products.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kaempferia parviflora Rhizome Extract as Potential Anti-Acne Ingredient

et al. 2022

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“…Mesua ferrea seeds were used to create numerous xanthones, some of which are thought to have biological effects that are thought to be anti-arthritic (Jalalpure et al, 2011). These xanthones could be used to create alternative natural anti-acne formulations (Nakyai et al, 2021).…”

Section: New Folk Medicinal Plantsmentioning

confidence: 99%

Medicinal plants used in Soran district Kurdistan region of Iraq, an ethnobotanicals study

Abdulwahid-Kurdi¹,

Abdulwahid²,

Usman³

et al. 2023

J Pharm Pharmacogn Res

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Context: The current study, the first of its type, focuses on the ethnobotanical uses of 97 medicinal plant species by the inhabitants in the Soran area, Kurdistan region of Iraq. Aims: To evaluate local knowledge of medicinal plants and provision of preliminary data on the user-benefit of the accessible plant species in the area. Methods: Between October 2021 and May 2022, key informant interviews were conducted as part of an ethnobotanical survey. Information about a particular study through face-to-face interviews with 171 participants (98 males and 73 females) were collected. For the therapeutic plants considered in the study, quantitative indices such as use value (UV), family use value (FUV), the relative frequency of citation (RFC), fidelity level (FL), and informant consensus factor (ICF) were applied in addition to detailed notes on each plant species. Results: The survey discovered 97 plant species and 41 plant families. Leaves were the plant portion that was used the most (44%) while seeds were the least (12%). The most popular three methods of preparation were decoction (52%), row (36%), and crushed (6%). The Olea europaea species had the highest use values (0.82), while Vitex agnus-castus had (0.005). Amaryllidaceae had the highest family use value (1.218), while Asteraceae had (0.005). According to the consensus index, Ficus carica and Datura stramonium had (140.84%) and (1.011%). The digestive tract disease category was shown to have the highest informant consensus factor value out of all disease categories (0.57), while the lowest value ICF was (0.0) for tooth pain. Conclusions: As a result of the development of natural medicines, this study gives information on the indigenous medicinal plants utilized in the Soran district to treat common illnesses that are ready for additional pharmacological and phytochemical examination. For better use of natural resources, the traditional use of plants requires conservation methods and additional research.

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“…The total phenolic content of the extract was determined by using Folin-Ciocalteu assay as previously reported [32].…”

Section: Total Phenolic Contentmentioning

confidence: 99%

“…The antioxidant capacities were measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric ion reducing antioxidant power (FRAP), 2,2 -azino-bis-(3-ethylbenzothiazoline-6sulfonic acid) (ABTS) and nitric oxide (NO) radical scavenging methods as previously reported [32].…”

Section: Antioxidant Assaysmentioning

confidence: 99%

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

et al. 2022

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Ultraviolet-B (UVB) exposure is one of the primary extrinsic factors causing skin photoaging. It stimulates inflammatory responses and arrests the cell cycle. Matrix metalloproteinase-1 (MMP-1) secreted by keratinocytes is one of the important extracellular matrixes to attenuate UVB-induced skin aging via collagen degradation. Curcuma aromatica (CA) and Curcuma comosa (CC), the herbaceous plants in the Zingiberaceae family, are commonly used in Thai traditional women’s medicines. The present work was aimed to investigate the potential of the CA and CC extracts and their isolated compounds to attenuate UVB-induced MMP-1 and cell cycle arrest in HaCaT keratinocytes. Total phenolic contents and antioxidant capacities of the extracts were determined. CC extract contains more phenolic components and provides more potent antioxidant activities than CA extract. HaCaTs were pretreated with the extracts or their isolated constituents 1–4 for 24 h and then repeatedly exposed to UVB at 100 mJ/cm2 10 times. Both extracts and compounds 1–4 effectively reduce UVB-induced MMP-1 levels in HaCaT cells and restore cell cycle arrest. This is the first report on the potential of CA and CC extracts in reducing UVB-induced MMP-1 expression and regulating cell proliferation in HaCaT cells. Thus, CA and CC extracts might be used as alternative natural agents to prevent UVB-induced skin photoaging.

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Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

Cited by 16 publications

References 54 publications

Kaempferia parviflora Rhizome Extract as Potential Anti-Acne Ingredient

Kaempferia parviflora Rhizome Extract as Potential Anti-Acne Ingredient

Medicinal plants used in Soran district Kurdistan region of Iraq, an ethnobotanicals study

Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells

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