Kaempferia parviflora Rhizome Extract as Potential Anti-Acne Ingredient

Abstract

Kaempferia parviflora (Black ginger) is used widely in medical fields as an anti-microorganism and anti-inflammation. In this study, the aim was to evaluate the in vitro and in vivo anti-acne efficacy of black ginger extract. The results indicate that the methanol and ethanol extracts showed the highest total phenolic contents, without a significant difference, whereas the n-hexane extract showed the highest total flavonoid content. Nine flavones were detected using UPLC−QTOF−MS, and the ethyl acetate extract showed the highest amount of 5,7-dimethoxyflavone (DMF) according to HPLC. Antibacterial activity against Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes was observed. All the extracts showed antimicrobial activity against C. acnes, revealing MICs in the range of 0.015 to 0.030 mg/mL, whereas the ethyl acetate extract inhibited the growth of S. epidermidis with a MIC of 3.84 mg/mL. In addition, the ethyl acetate extract showed the highest activity regarding nitric oxide inhibition (IC50 = 12.59 ± 0.35 µg/mL). The ethyl acetate extract was shown to be safe regarding cell viability at 0.1 mg/mL. The anti-acne efficacy was evaluated on volunteers. The volunteers were treated in two groups: one administered a 0.02% ethyl acetate extract gel-cream (n = 9) and one administered a placebo (n = 9) for 6 weeks. The group treated with the gel-cream containing the extract showed 36.52 and 52.20% decreases in acne severity index (ASI) after 4 and 6 weeks, respectively, and 18.19 and 18.54% decreases in erythema, respectively. The results suggest that K. parviflora could be a potent active ingredient in anti-inflammatory and anti-acne products.

Clinical dermatologic applications of ginger: a focused review

“…Sitthichai et al conducted a study in which volunteers with acne applied twice daily formulations of black ginger with different solvents for 6 weeks and demonstrated significant improvement in acne vulgaris and erythema. 18 As a potential skin-whitening agent, Huang et al 19 assessed the effects of 6-gingerol on mushroom tyrosinase and B16F10 melanoma cells. They demonstrated that 6-gingerol reduced tyrosinase activity and inhibited melanin synthesis in a dosedependent manner.…”

“…Sitthichai et al. conducted a study in which volunteers with acne applied twice daily formulations of black ginger with different solvents for 6 weeks and demonstrated significant improvement in acne vulgaris and erythema 18 …”

Kaempferia parviflora Extracellular Vesicle Loaded with Clarithromycin for the Treatment of Helicobacter pylori Infection

“…KP rhizome, also known as black ginger, contains anti-microorganism, anti-inflammatory, anticancer, antiallergic, anti-osteoarthritis, antioxidant, cardioprotective, neuroprotective, sexual-enhancing, and physicalenhancing activities. [1][2][3][4][5][6] The major active compounds are methoxyflavones and their derivatives. 6 Our previous study demonstrated the inhibitory activity of crude KP extract against Helicobacter pylori, an etiological agent of gastric cancer.…”

Effect of Different Shading Color on Growth and Yield Performance of (Black Ginger) Kaempferia parviflora Wall. ex Baker

“…One of the most well-known benefits of K. parviflora is its aphrodisiac effects [2,3]. In addition, K. parviflora has also been found to have anti-inflammatory and antioxidant properties [4,5]. These properties help reduce inflammation in the body and protect cells from oxidative stress, which can help prevent chronic diseases such as heart disease and cancer.…”