“…Recently, a diverse range of engineered nanomaterials have been developed and widely applied in the industrial, environmental, and biomedical fields [1,2,3,4]. Mesoporous silica nanoparticles (MSNs) have been regarded as especially promising materials for biomedical and pharmaceutical applications, above all drug delivery, owing to their unique surface characteristics, high surface area, large pore volume and good biocompatibility [5,6,7,8,9]. Consequently, bio-functionalized MSNs have been widely applied for controlled drug delivery in targeted cancer therapy [10,11,12,13,14].…”