A Gentle Sedimentation Process for Size-Selecting Porous Silicon Microparticles to Be Used for Drug Delivery Via Fine Gauge Needle Administration

Nekovic, Elida; Storey, Catherine J.; Kaplan, A.; Theis, Wolfgang; Canham, Leigh

doi:10.1007/s12633-020-00895-3

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…However, they lose implementation niches where semiconductor nanomaterials play a significant role covering many applications such as singlet oxygen generation, cancer theranostics, optical nanothermometry, and multimodal linear/nonlinear optical bioimaging [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Moreover, silicon-based nanostructures can also serve as efficient drug nanocarriers providing a simultaneous ultrasound-activated antimicrobial effect [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

et al. 2023

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Plasmonic nanostructures have attracted a broad research interest due to their application perspectives in various fields such as biosensing, catalysis, photovoltaics, and biomedicine. Their synthesis by pulsed laser ablation in pure water enables eliminating various side effects originating from chemical contamination. Another advantage of pulsed laser ablation in liquids (PLAL) is the possibility to controllably produce plasmonic nanoparticles (NPs) in combination with other plasmonic or magnetic materials, thus enhancing their functionality. However, the PLAL technique is still challenging in respect of merging metallic and semiconductor specific features in nanosized objects that could significantly broaden application areas of plasmonic nanostructures. In this work, we performed synthesis of hybrid AuSi NPs with novel modalities by ultrashort laser ablation of bulk gold in water containing silicon NPs. The Au/Si atomic ratio in the nanohybrids was finely varied from 0.5 to 3.5 when changing the initial Si NPs concentration in water from 70 µg/mL to 10 µg/mL, respectively, without requiring any complex chemical procedures. It has been found that the laser-fluence-insensitive silicon content depends on the mass of nanohybrids. A high concentration of paramagnetic defects (2.2·× 1018 spin/g) in polycrystalline plasmonic NPs has been achieved. Our findings can open further prospects for plasmonic nanostructures as contrast agents in optical and magnetic resonance imaging techniques, biosensing, and cancer theranostics.

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Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

et al. 2023

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“…For drug delivery options, biodegradable porous silicon particles under development for drug delivery with optimum particle size can be used as smart nanocarriers. The particle size depends upon medical use, and microparticles can perform specific illustrations as smart carriers [11].…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Mesoporous Silica Nanoparticles with Hexamethyl Disilazane as Smart Carriers for Tocopherol Acetate

Shiekh¹,

Mushtaq²,

Jabeen³

et al. 2022

Nano BioMed ENG

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Nowadays, nanotechnology is growing very fast, appearing every day in many fields related to this nanotechnology. In the present study silica nanoparticles (Si NPs) were synthesized, their surface was modified using a silazane and mesoporous Si NPs were further used for the loading tocopherol acetate. Si NPs were synthesized from tetraethyl orthosilicate (TEOS) in the presence of NaOH, with an easily handled, well known Stober method. In this, procedure TEOS was used as a source of silica and treated with NaOH and H 2 O, undergoing condensation and hydrolysis reactions to produce Si NPs. These Si NPs were then modified by the hexamethyl silazane to avoid agglomeration and can be used easily for targeted delivery, as smart carriers. In the end, tocopherol acetate was successfully loaded in the modified Si NPs and different parameters were recorded for optimum loading. All the samples were characterized through SEM XRD, FTIR, BET and UV-VIS spectroscopy. XRD peaks reveled the typical peak of mesoporous Si NPs appeared at 2θ = 22°. The pore size was found to be 2.45 nm. BET surface area was found to be 694.29 m 2 /g. FTIR presented the main peaks of functional groups at 1600 cm -1 , 1000 cm -1 and 2900 cm -1 respectively. Modified Si NPs were synthesized and characterized, and the tocopherol was loaded inside the mesoporous Si NPs successfully. These experiments showed that mesoporous Si NPs can be used as smart carriers to deliver broad types of drugs efficiently.

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A Gentle Sedimentation Process for Size-Selecting Porous Silicon Microparticles to Be Used for Drug Delivery Via Fine Gauge Needle Administration

Cited by 2 publications

References 24 publications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Environmentally Friendly Improvement of Plasmonic Nanostructure Functionality towards Magnetic Resonance Applications

Surface Modification of Mesoporous Silica Nanoparticles with Hexamethyl Disilazane as Smart Carriers for Tocopherol Acetate

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