<em>This research aims to arrange learning materials that include definitive , macroscopic, microscopic, and valid symbolic to know the student response through multi-representation materials. This research was conducted in SMA Negeri 1 Karangtengah, with subjects are XI IPA 3 students. This research is applied in alkali acid materials. The data that is obtained in this research are expert validation result and students response in material multi representation media : definitive, macroscopic, microscopic , symbolic. The data interpretation was conducted with expert judgment to know materials validation, and questionnaireto know students response through multi representation materials : definitive, macroscopic, microscopic , symbolic are validated by three validator. The research outcome shows that multi representation material media : definitive, macroscopic, microscopic , symbolic valid with average score from total score 75. The students response through multi representation materials shows the possitive response through the materials.</em>