Mechanism of Stone Formation

Balaji, K.C.; Menon, Mani

doi:10.1016/s0094-0143(05)70350-5

Cited by 96 publications

(78 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urine pH (<5.5 for uric acid stones and >6 for calcium stones) is a surrogate marker for determining the type of calculi. Particularly, in CaOx urolithiasis, the remarked basicity of the urine beyond pH 7.2 initiates the nucleation of phosphate and oxalate with calcium (Balaji & Menon, 1997;Rivers et al, 2000). In the present study, young male albino rats show increased pH (7.82) and form renal calculi composed mainly of CaOx in response to 14 days oral supplement of EG.…”

Section: Discussionsupporting

confidence: 51%

See 1 more Smart Citation

Curative treatment with extracts ofBombax ceibafruit reduces risk of calcium oxalate urolithiasis in rats

Gadge

Jalalpure

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 51%

“…The major factors are supersaturation of urine with the offending salt and crystallization. Crystals retained in kidney become nucleus for stone formation (Balaji & Menon, 1997). Majority of urinary calculi are made up of calcium phosphate (CaPh), calcium oxalate (CaOx), uric acid (urates) or magnesium ammonium phosphate.…”

Section: Introductionmentioning

confidence: 99%

Curative treatment with extracts ofBombax ceibafruit reduces risk of calcium oxalate urolithiasis in rats

Gadge

Jalalpure

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

“…The majority of urinary oxalate is derived from the endogenous metabolism of glyoxylate and ascorbic acid and 10-20% is derived from oral ingestion (6,14). The colon is the major site of oxalate absorption, and 3-5% of dietary oxalate is absorbed under normal conditions.…”

mentioning

confidence: 99%

Oxalate‐Degrading Enterococcus faecalis

Hokama

Honma

Toma

et al. 2000

Microbiology and Immunology

View full text Add to dashboard Cite

An oxalate-degrading Enterococcus faecalis was isolated from human stools under anaerobic conditions. The bacteria required a poor nutritional environment and repeated subculturing to maintain their oxalate-degrading ability. The E. faecalis produced 3 proteins (65, 48, and 40 kDa) that were not produced by non-oxalate-degrading E. faecalis as examined by SDS-PAGE. Antibodies against oxalyl-coenzyme A decarboxylase (65 kDa) and formyl-coenzyme A transferase (48 kDa) obtained from Oxalobacter formigenes (an oxalate-degrading anaerobic bacterium in the human intestine) reacted with 2 of the proteins (65 and 48 kDa) from the E. faecalis as examined by Western blottings. This is the first report on the isolation of oxalate-degrading facultative anaerobic bacteria from humans.

show abstract

“…It affects 1-5% of the population in industrialised countries, with a lifetime risk of 20% in white men and 5-10% in women. 4 In our study majority of the patients were male (M:F 3:1) in their 3 rd to 4 th decade with mean age of 38.57 years. Similar observation was made by Pincus et al, in their study majority of patients were male upto 85% with maximum incidence in 3 rd to 4 th decade of life.…”

Section: Discussionmentioning

confidence: 63%

Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

Godara

Srivastava

Vashist

et al. 2013

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Acute renal colic is excruciatingly painful event, opioid analgesics and nonsteroidal anti-inflammatory drugs remain the mainstay of treatment for acute renal colic. This study compares diclofenac and lornoxicam in their efficacy to relieve pain of renal origin. Methods: Prospective, randomized, double blind clinical study including eighty patients with renal pain admitted in emergency department of a tertiary care teaching hospital. Parameters were observed at baseline and after 15, 30, 60, 180 minutes and 5hrs of drug treatment. The efficacy of the drug was measured by observing: Pain score, onset & duration of action, rescue drug use, global patient and physician impression. Results: Both drugs are effective in relieving pain of renal origin (p<0.05) and maintaining it over time as well. When decrease in value of pain score compared between two groups at various interval there was statistically significant (p<0.05) decrease in pain score only at 15 minutes in lornoxicam group showing this slightly more effective in early phase compared to diclofenac. In either group there is no statistically significant difference regarding onset of action, duration of action and side effect profile. Conclusions: Both the drugs are equally effective and safe in renal colicky pain with added advantage of lornoxicam being more effective in early period. [Int J Basic Clin Pharmacol 2013; 2(2.000): 193-198

show abstract

Mechanism of Stone Formation

Cited by 96 publications

References 35 publications

Curative treatment with extracts ofBombax ceibafruit reduces risk of calcium oxalate urolithiasis in rats

Curative treatment with extracts ofBombax ceibafruit reduces risk of calcium oxalate urolithiasis in rats

Oxalate‐Degrading Enterococcus faecalis

Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

Contact Info

Product

Resources

About