Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

Godara, Sushila; Srivastava, Ragini; Vashist, M. G.; Godara, Rajesh

doi:10.5455/2319-2003.ijbcp20130314

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Similar to our study there are few studies available comparing the efficacy and safety of lornoxicam and diclofenac, Vishalkumar et al studied the efficacy and safety of lornoxicam and diclofenac in osteoarthritis knee patients the results showed that lornoxicam significantly relieved pain more than diclofenac [14]. Sushila godara et al conducted a study by comparing lornoxicam and diclofenac in the management of acute renal colic and concluded that both the drugs are equally effective and safe with added advantage of lornoxicam being more effective in the early period [15].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Efficacy and Safety of Lornoxicam and Diclofenac as Postoperative Analgesics After Mastoidectomy Surgery

Ramarao

Ezhilramya

2017

Int J Pharm Pharm Sci

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Objective: The objective of the research was to evaluate the efficacy and safety of lornoxicam compared to diclofenac in the management of postoperative pain following mastoidectomy surgery. Methods:The present study was a prospective, single-blinded, randomised study. 80 mastoidectomy patients were randomised into two groups. Group A received lornoxicam 8 mg and group B received diclofenac 75 mg intramuscularly twice daily for 3 consecutive days. The primary parameter was to analyse the postoperative pain using visual analogue scale (VAS) and Wong Bakers scale (WBS). The secondary parameters were the usage of rescue medication and time to use rescue medication. Results:There was a significant reduction in the postoperative pain in the lornoxicam group than the diclofenac group (p value<0.05) throughout the study. Significantly 11 patients required rescue medication in diclofenac group, 3 patients in lornoxicam group. No serious adverse event was noted in two groups. Conclusion:Lornoxicam 8 mg was a better analgesic than diclofenac 75 mg in efficacy and safety in the management of postoperative pain following mastoidectomy surgery.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of Efficacy and Safety of Lornoxicam and Diclofenac as Postoperative Analgesics After Mastoidectomy Surgery

Ramarao

Ezhilramya

2017

Int J Pharm Pharm Sci

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“…Both nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are gold standards for relieving pain with acute renal colic (3,4). Although opioids are potent and cheap, they have some adverse events (AEs) such as nausea, vomiting, constipation, respiration depression (in larger doses), drowsiness, and hypotension (5). Compare with NSAIDS, opioid has fewer complications such as drowsiness, vomiting, and nausea; but it was demonstrated they can develop AEs such as nephropathy and platelet dysfunction (6).…”

Section: Introductionmentioning

confidence: 99%

Intranasal Ketamine Versus Intravenous Ketorolac for Pain Control in the Renal Colic: A Randomized Clinical Trial Study

Khavanin

Moezzi

Motamed

et al. 2021

Jundishapur J Chronic Dis Care

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Background: Renal colic is one of the most common complaints among patients referring to the emergency department (ED). Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are gold standards to relieve pain. Objectives: The aim of this study was to evaluate the effects of intranasal Ketamine on pain control versus Ketorolac. Methods: In this randomized clinical trial (RCT), the patients were randomly assigned into two groups. While Ketorolac 30 mg was given intravenously to all patients in the control group, the patients in intervention group received 1 mg/kg drops of Ketamine intranasally. Pain severity, vital signs, and adverse events (AEs) were recorded after 60 min post-dose. Results: A total of 100 patients were enrolled in this study. The mean visual analog scale (VAS) score after the first 5 min was lower in the intranasal Ketamine group compared to control (5 ± 2.26 vs. 8.62 ± 0.49, respectively; P < 0.001), which remained significant at the end of 60th min (P < 0.001). Moreover, additional analgesics administration was higher in intravenous Ketorolac than intranasal Ketamine (22 vs 0%), which was significantly different (P = 0.001). Patients' satisfaction was higher in the intranasal Ketamine group compared to control (3.56 ± 0.35 vs. 1.82 ± 0.98, respectively; P < 0.001). Conclusions: Intranasal Ketamine was beneficial in controlling renal colic-induced pain, which could be prescribed as a treatment instead of normal treatment. It can rapidly improve pain relief in the short term, has lower AEs, and increases the patients' satisfaction.

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“…Although opioids are cheap and potent and can be easily titrated but they have various adverse effects as constipation, drowsiness, nausea, and vomiting, larger doses lead to depression of respiration, hypotension, and drug seeking behavior presenting as renal colic [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Lornoxicam with Low-Dose Ketamine versus Pethidine to Control Pain of Acute Renal Colic

Metry

Fahmy

Nakhla

et al. 2019

Pain Research and Treatment

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Objectives. This study was established to compare single-dose lornoxicam 8 mg (NSAID) in addition to 0.15 mg.kg−1 ketamine with single-dose pethidine 50 mg, both administered intravenously (IV), on the quickness and extent of analgesia, disadvantage, and consequence on utilitarian situation. Patients and Methods. One hundred and twenty patients with acute renal colic pain received in emergency room were included in this prospective, randomized, and double blind clinical study. They were aimlessly designated into one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg−1 ketamine and Group P received pethidine 50 mg IV. Parameters were noticed at baseline and after 0, 15, 30, and 45 minutes and 1 hour after drug administration. The efficiency of the drug was determined by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events, and functional status. Results. The visual analogue scale was significantly lower in Group L after 30 minutes in comparison to Group P. In addition, there was statistically significant increase in Group P regarding their need for rescue analgesia after 30 min in comparison to Group L. Group P showed nonsignificantly increased sedation score compared to Group L. Conclusion. Patients receiving lornoxicam-ketamine attained greater reduction in pain scores and less side effects with better functional state and also are less likely to require further analgesia than those administered pethidine to control acute renal colic pain.

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Lornoxicam versus diclofenac sodium in acute renal colic: a prospective randomized trial

Cited by 4 publications

References 8 publications

A Comparative Study of Efficacy and Safety of Lornoxicam and Diclofenac as Postoperative Analgesics After Mastoidectomy Surgery

A Comparative Study of Efficacy and Safety of Lornoxicam and Diclofenac as Postoperative Analgesics After Mastoidectomy Surgery

Intranasal Ketamine Versus Intravenous Ketorolac for Pain Control in the Renal Colic: A Randomized Clinical Trial Study

Lornoxicam with Low-Dose Ketamine versus Pethidine to Control Pain of Acute Renal Colic

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