Curative treatment with extracts of<i>Bombax ceiba</i>fruit reduces risk of calcium oxalate urolithiasis in rats

Gadge, Navneet B.; Jalalpure, Sunil

doi:10.3109/13880209.2011.604332

Cited by 29 publications

(16 citation statements)

References 31 publications

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“…Oxalate is the precursor molecule for lipid peroxidation, which reacts with polyunsaturated fatty acids in the cell membrane and damage the renal tissue. 44 Co-treatment with nBFMU decreased the size and number of CaOX crystal deposition in renal tubules and also prevented damages in the calyxes and tubules. Such rapid and acute diuretic activity of nBFMU may be due to presence of active phytochemicals such as flavonoids, steroids, terpenoids and phenolic compound.…”

Section: Discussionmentioning

confidence: 84%

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

Patel¹,

Acharya²

2020

IJPER

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Background: Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of n-butanol fraction of M. uniflorum (nBFMU) on kidney stone using in vitro and in vivo method. Materials and Methods: Nucleation, crystal growth, crystal aggregation and crystal dissolution assays were performed for nBFMU. Two doses of nBFMU (400 and 800 mg/kg) were studied for their diuretic activity and sodium oxalate (NaOx) (70 mg/kg, i.p) induced urolithasis in male Wistar albino rats. Determination of body and kidney weight, measurement of various biochemical parameters in biological samples and examination of histology of kidney at the end of experiment were also done. Results: nBFMU exhibited a concentration dependent inhibitory activity on nucleation and aggregation along with decreased number of crystals of calcium oxalate (CaOX) produced in metastable solutions of CaOX in the in vitro experiments. Co-administration of nBFMU with NaOX has significantly (p<0.001) increased the urine volume and the level of calculus inhibitors like magnesium, citrate and decreased the level of calculus promoters like oxalate, calcium, urea and uric acid. nBFMU supplement also prevented the pathological changes in kidney and increased the glomerulus activity of the kidney. Conclusion: These results indicate that nBFMU showed significant activity in urolithiasis which might be due to its diuretic, CaOX crystal formation inhibitory effects and its ability to increase the levels of inhibitors and decrease the level of promoters of urolithiasis.

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Section: Discussionmentioning

confidence: 84%

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

Patel¹,

Acharya²

2020

IJPER

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“…Animals divided into seven experimental groups (n = 6) as follows: Group I served as a normal control (NC), maintained on regular rat pellet diet and drinking water ad libitum, and received distilled water as vehicle (5 ml/kg b.w., p.o.). Urolithiasis in remaining groups was induced by coadministration of 0.75% v/v EG and 1% w/v AC in drinking water ad libitum for first 3 days to augment lithiatic effect of EG, followed by 0.75% v/v EG alone for 18 days [15,16]. Group II served as disease control (DC) and receive distilled water (5 ml/kg b.w., p.o.).…”

Section: Experimental Designmentioning

confidence: 99%

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Kyada¹,

Mansuri²,

Patel³

2017

J Intercult Ethnopharmacol

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Aim: Antiurolithiatic activity of magnesium lactate gluconate (MLG) and aqueous extract of Garcinia cambogia (GC) fruit was studied. Materials and Methods: The study was performed during December 2016 to April 2017. Urolithiasis was induced in male Wistar rats by administration of 0.75% v/v ethylene glycol for 21 days. From 8 th day onward, intervention with MLG (200 and 400 mg/kg b.w.) and GC (100 and 200 mg/kg b.w.) was started. At the end of the treatment period, biochemical parameters affecting renal stone formation were estimated in the serum, urine, kidney homogenate, and histopathology of harvested kidneys was performed. Results: From in vivo evaluation, it was observed that MLG 400 mg/kg b.w., GC 100 mg/kg b.w., and GC 200 mg/kg b.w. significantly reduced nitrogenous waste products in serum (blood urea nitrogen, creatinine, and uric acid) as well as calculogenic promoters in urine (phosphate and oxalate) and kidney homogenate (calcium, phosphate, and oxalate) when compared to disease control animals. The MLG 200 and MLG 400 were ineffective in restoring superoxide dismutase (SOD) and catalase (CAT) enzyme activity, whereas GC 100, GC 200, and Cystone ® 400 mg/kg b.w. significantly elevated SOD and CAT enzymes in urolithiatic rat kidney. Conclusions: MLG and GC extracts are capable of preventing calcium oxalate (CaOx) crystal formation and subsequent deposition in renal tubules. The principle mechanism underlying nephroprotective effect of test drugs might be attributed to their calcium ion chelating ability and CaOx crystallization inhibitory activity. It is further asserted that GC was more potent than MLG in overall kidney protection by virtue of its antioxidant potential.

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“…Several studies reported the hepatic protective, antibacterial, antiviral, antioxidant, hypotensive, antiangiogenic, anti-hepatitis B virus (HBV), and antiinflammatory effects [7][8][9][10]. A recent study demonstrated the potential role of the fruit of B. ceiba in the treatment of urolithiasis [11]. Phenols, sesquiterpenoids, steroids, naphthoquinones and neolignans have been isolated from different parts of B. ceiba [12,13].…”

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confidence: 99%

In vitro Cancer Cell Growth Inhibition and Antioxidant Activity of Bombax ceiba (Bombacaceae) Flower Extracts

Tundis

Rashed

Said

et al. 2014

Natural Product Communications

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The flowers of Bombax ceiba were investigated for their chemical composition, antioxidant effects and antiproliferative activity against seven human cancer cell lines. The antiproliferative responses of diethyl ether (DE) and light petroleum (PE) extracts were evaluated by sulforhodamine B (SRB) assay against MCF-7, HeLa, COR-L23, C32, A375, ACHN, and LNCaP cells in comparison with a human normal cell line, 142BR. Moreover, extracts were characterized by GC-MS analysis and tested for their antioxidant properties by different in vitro systems, namely DPPH, Fe-chelating activity and -carotene bleaching test. Both PE and DE extracts showed the highest antiproliferative activity against human renal adenocarcinoma (ACHN) in a concentration-dependent manner. PE extract showed the highest radical scavenging activity against the DPPH radical, while DE extract was more active in the -carotene bleaching test. The presence of -sitosterol and some fatty acids may contribute to the bioactivity of B. ceiba flower extracts.

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Curative treatment with extracts ofBombax ceibafruit reduces risk of calcium oxalate urolithiasis in rats

Cited by 29 publications

References 31 publications

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

Anti-urolithiatic activities of Macrotyloma uniflorum Mediated through Multiple Pathway

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

In vitro Cancer Cell Growth Inhibition and Antioxidant Activity of Bombax ceiba (Bombacaceae) Flower Extracts

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