Measurement of Choroidal Melanomas: A Comparison of Methods

Abstract

The prognosis for death from metastatic choroidal melanoma following enucleation has been shown to

Tumor Basal Area and Metastatic Death After Proton Beam Irradiation for Choroidal Melanoma

“…S EVERAL METHODS for modeling the relationship between patient survival time and tumor dimension in ocular melanoma have been proposed in the literature. [1][2][3][4][5][6][7][8][9] Although there is no consensus on the optimal approach, the linear form of the largest tumor diameter (LTD) in contact with the sclera has been most commonly adopted. [10][11][12][13][14][15][16][17][18][19][20] Both LTD and tumor volume are considered to be correlated with the time since tumor onset or with its aggressiveness and thus its metastatic potential.…”

Three-Dimensional Ultrasound for the Measurement of Choroidal Melanomas

“…Favilla et al 28 used linear regression analysis to find the functional relationship between B-scan volume and the volume calculated from A ϫH. The B-scan volume was measured using ultrasonographic tomography and computer-assisted calculation of area of each tomographic slice, the sum of which constituted the volume.…”

Tumor Regression After Brachytherapy for Choroidal Melanoma: Reduction of Thickness and Cross-Sectional Area by Shape and Regression Pattern

“…For example, the base of a mushroom-shaped melanoma seems to regress to a different extent than the part that has broken through Bruch's membrane. Although volume measurements of uveal melanoma have been obtained from time to time, 38,[41][42][43][44] none of these methods has become routine. Formulas for estimating tumor volume from two-dimensional measurements of uveal melanoma have proved inconsistent and largely unsatisfactory.…”

“…Formulas for estimating tumor volume from two-dimensional measurements of uveal melanoma have proved inconsistent and largely unsatisfactory. 35,38,40,42,44 We address the hitherto unexplored relationship between the height and cross-sectional area of choroidal melanomas and their regression after brachytherapy, and analyze the rate and pattern of regression of both measures relative to tumor shape. We use cross-sectional area as a presumed closer surrogate for tumor volume than tumor thickness.…”