2009
DOI: 10.1159/000212383
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Abstract: Background and Aims: The steroid ouabain is found in plasma and in many mammalian tissues, and is now considered as a hormone. In the immune system, ouabain regulates a number of lymphocyte functions, but little is known about its effects on monocyte function. Monocytes are important for adequate immune responses. The aim of this work was to analyze the effect of ouabain on mCD14 expression, a surface molecule involved in the response against Gram-negative bacteria and phagocytosis. Methods: Human peripheral b… Show more

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Cited by 20 publications
(31 citation statements)
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“…Thus, Alvardo-Kristensson and co-authors reported that p38 MAPK contributes to survival of human neutrophils by consequent phosphorylation and inhibition of caspase-8 and caspase-3 [32]. Valente and co-workers demonstrated that ouabain augments SB 202109-sensitive p38 phosphorylation in human peripheral blood mononuclear cells without any impact on cell survival [33]. In contrast, mouse and human macrophages apoptosis triggered by activation of P2X receptors and ROS is mediated by p38 activation [34,35].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, Alvardo-Kristensson and co-authors reported that p38 MAPK contributes to survival of human neutrophils by consequent phosphorylation and inhibition of caspase-8 and caspase-3 [32]. Valente and co-workers demonstrated that ouabain augments SB 202109-sensitive p38 phosphorylation in human peripheral blood mononuclear cells without any impact on cell survival [33]. In contrast, mouse and human macrophages apoptosis triggered by activation of P2X receptors and ROS is mediated by p38 activation [34,35].…”
Section: Discussionmentioning
confidence: 99%
“…The activation of monocytic cell line surface EGFR and its downstream signaling cascades can stimulate the secretion of proinflammatory cytokines [70] and the acquisition of an antiapoptotic state [72]. Valente et al [73] found that the EGFRK activity of primary human monocytes mediated the up-regulation of CD14 by steroid ouabain. In accord with these observations, we have shown recently, for the first time, low-level EGFR expression on the surface of primary human peripheral blood monocytes [19], which has been confirmed subsequently [74].…”
Section: Monocytes Exress Bona Fide Surface Egfr Which Is Activated mentioning
confidence: 99%
“…Certain studies have shown important implications of the ouabain hormone in cell proliferation, muscle contraction and cell survival in distinct cell types (32)(33)(34). In the immune system, ouabain modulates the expression of several important receptors in lymphocytes and monocytes (35,36), impairs lymphocyte proliferation induced by mitogens (36) and induces cytokine secretion in PBMC (37,38). In addition, the in vivo administration of ouabain has been shown to reduce the amount of mature B lymphocytes in the spleen and prevent the inflammation induced by several substances in mice (39,40).…”
Section: Discussionmentioning
confidence: 99%