Maternal testosterone in pregnancy and atopic outcomes in childhood

Shaheen, Salma; Hines, Melissa; Newson, R B; Wheeler, Michael J.; Herrick, David; Strachan, David P.; Burney, Peter; Henderson, John

doi:10.1111/j.1398-9995.2006.01240.x

Cited by 24 publications

(17 citation statements)

References 43 publications

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“…Acne was not associated with asthma/atopy outcomes among male students either, thus not supporting a role of testosterone in these outcomes in our cohort (16). Acne is only an indirect marker of high testosterone levels, although we have previously reported a lower cardiovascular disease and higher prostate cancer mortality among students with acne, suggesting it does identify high levels of this hormone (17).…”

Section: Discussioncontrasting

confidence: 69%

The Association Between Irregular Menstruations and Acne With Asthma and Atopy Phenotypes

Galobardes¹,

Patel²,

Henderson³

et al. 2012

American Journal of Epidemiology

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Earlier menarche and irregular periods, among other markers of sex-hormone levels, have been associated with a higher risk of asthma and allergic diseases. This has suggested an etiologic role of sex hormones in the development of these conditions. The authors investigated the association of age at menarche, irregular periods, duration of menstruation, and acne with reported medical history of asthma and/or atopy (hay fever and/or eczema/urticaria) in a historical cohort of students born before the rise in asthma prevalence in the United Kingdom and attending university in 1948–1968. Finding consistent associations in a cohort that has experienced different life-course exposures and has different confounding structure can help to identify causal associations. In the Glasgow Alumni Cohort, irregular periods were associated with atopic asthma (multinomial odds ratio (MOR) = 2.79, 95% confidence interval (CI): 1.33, 5.83) and atopy alone (MOR = 1.40, 95% CI: 1.06, 1.84) but not with nonatopic asthma (MOR = 1.02, 95% CI: 0.45, 2.30), compared with students reporting no asthma and no atopy. The authors found no association with acne, a marker of high testosterone levels, that they hypothesized could point to polycystic ovary syndrome underpinning these associations. In summary, the authors found evidence for a potentially etiologic role of irregular menstruations with some specific asthma phenotypes, namely, atopic asthma and atopy, but not with nonatopic asthma.

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Section: Discussioncontrasting

confidence: 69%

The Association Between Irregular Menstruations and Acne With Asthma and Atopy Phenotypes

Galobardes¹,

Patel²,

Henderson³

et al. 2012

American Journal of Epidemiology

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“…Other risk factors could explain some of the ratios in Tables and , such as immunologic, allergic, infectious, hormonal (especially sex hormones), genetic, biologic, and environmental (in‐utero and post‐natal), as well as diagnostic bias. These other risk factors are not reviewed in detail although examples of their impact would include the finding that high testosterone levels in pregnancy are associated with lower IgE production in boys but was not associated with rates of atopic disease . Also, it has been noted that higher levels of androgens in male fetuses interfere with surfactant production, resulting in increased rates of respiratory distress syndrome (RDS) in male neonates compared to female neonates of the same gestational age.…”

Section: Introductionmentioning

confidence: 99%

Sex and the lung: Observations, hypotheses, and future directions

2015

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Sex-related differences in a variety of lung diseases in infants and young children are reviewed, including respiratory distress syndrome, and chronic lung disease of prematurity, lower respiratory tract illnesses and wheezing, asthma, diffuse, and interstitial lung diseases, and cystic fibrosis. Differences in anatomy and physiology, such as airway size, airway muscle bulk, airway reactivity, airway tone, and cough reflexes may explain much of these sex differences. Better understanding of sex-related lung differences could help personalize respiratory treatment.

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“…In the mother, sex steroids are believed to underlie the association of pregnancy with risk of breast (1) and ovarian (2) cancers. In the child, an increasing body of evidence suggests that maternal sex steroids may influence the in-utero environment which may result in increased risk of atopy (3), autism spectrum and attention deficit hyperactivity disorders (4), polycystic ovary syndrome (PCOS) (5), testicular cancer (6), and probably breast cancer (7). High maternal testosterone concentrations have also been associated with low birth weight in the off-spring (8), with its attendant negative cardiovascular and metabolic sequelae (9).…”

Section: Introductionmentioning

confidence: 99%

Determinants of Maternal Sex Steroids During the First Half of Pregnancy

Toriola

Vääräsmäki

Lehtinen

et al. 2011

Obstetrics &Amp; Gynecology

118

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Objective To examine the associations of maternal and child characteristics with early pregnancy maternal concentrations of testosterone, androstenedione, progesterone, 17-hydroxyprogesterone and estradiol. Methods We analyzed these hormones among 1,343 women with singleton pregnancies who donated serum samples to the Finnish Maternity Cohort from 1986 to 2006 during the first half of pregnancy (median, 11 weeks). The associations of maternal and child characteristics with hormone concentrations were investigated by correlation and multivariable regression. Results Women above age 30 had lower androgen and estradiol but higher progesterone concentrations than women below that age. Multiparous women had 14% lower testosterone, 11% lower androstenedione and 17-hydroxyprogesterone, 9% lower progesterone, and 16% lower estradiol concentrations compared to nulliparous women (all P<.05). Smoking mothers had 11%, 18%, and 8% higher testosterone, androstenedione, and 17-hydroxyprogesterone levels, respectively, but 10% lower progesterone compared to non-smoking women (all P<.05). Estradiol concentrations were 9% higher (P<0.05) among women with a female fetus compared to those with a male fetus. Conclusions Parity, smoking, and to a lesser extent maternal age and child gender are associated with sex steroid levels during the first half of a singleton pregnancy. The effects of smoking on the maternal hormonal environment and the possible long-term deleterious consequences on the fetus deserve further evaluation.

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Maternal testosterone in pregnancy and atopic outcomes in childhood

Abstract: Higher testosterone levels in pregnancy are associated with lower IgE production in boys.

Cited by 24 publications

References 43 publications

The Association Between Irregular Menstruations and Acne With Asthma and Atopy Phenotypes

The Association Between Irregular Menstruations and Acne With Asthma and Atopy Phenotypes

Sex and the lung: Observations, hypotheses, and future directions

Determinants of Maternal Sex Steroids During the First Half of Pregnancy

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