Sex and the lung: Observations, hypotheses, and future directions

Liptzin, Deborah R.; Landau, Louis I.; Taussig, Lynn M.

doi:10.1002/ppul.23178

Cited by 69 publications

(58 citation statements)

References 71 publications

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“…The above criterion was applied in the similar studies, except in the Tunisian one [15] , where only 96 women were included [Table 4] . In order to avoid biased assessment of outcomes [40] and the sex-related effect on lung function [41] , similar percentages of men and women were included in this study. This was not the case of some others [15, 18, 19, 23] .…”

Section: Discussionmentioning

confidence: 99%

The multi‐ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry

et al. 2018

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BackgroundThe validation of the multi-ethnic GLI-2012 spirometric norms has been debated in several countries. However, its applicability in Algeria has not been verified.AimTo ascertain how well the GLI-2012 norms fit contemporary adult Algerian spirometric data.MethodsThis was a cross-sectional study of a convenience sample of 300 healthy non-smoker adults (50% men, age range: 18–85 years) recruited from the Algiers region general population. All participants underwent a clinical examination and a plethysmography measurement. Z-scores for some spirometric data [FEV1, FVC, FEV1/FVC and forced expiratory flow at 25–75% of FVC (FEF25-75%)] were calculated. If the average Z-score deviated by “< ± 0.5” from the overall mean, the GLI-2012 norms would be considered as reflective of contemporary Algerian spirometry.ResultsThe means±SDs of age, height, weight, FVC, FEV1, FEV1/FVC and FEF25-75% of the participants were, respectively, 48±17 years, 1.65±0.10 m, 73±14 kg, 4.04±1.04 L, 3.18±0.82 L, 0.79±0.05 and 4.09±1.09 L/s. Almost the quarter of participants were obese. The total sample means±SDs Z-scores were 0.22±0.87 for FVC, 0.04±0.88 for FEV1, -0.34±0.67 for FEV1/FVC and 0.93±0.79 for FEF25-75%. For men and women, only the means±SDs of the FEF25-75% Z-scores exceeded the threshold of “± 0.5”, respectively, 1.13±0.77 and 0.73±0.76.ConclusionResults of the present study, performed in an Algerian population of healthy non-smoking adults, supported the applicability of the GLI-2012 norms to interpret FEV1, FVC and FEV1/FVC but not the FEF25-75%.

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Section: Discussionmentioning

confidence: 99%

The multi‐ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry

et al. 2018

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“…The clinical course of inflammatory lung diseases is influenced by several factors including sex, hormones, and poor air quality (Doherty et al 2009;Liptzin et al 2015;Silva et al 2017). Sex differences in lung disease incidence, prevalence, and severity have been noted for years, as well as increased prevalence rates for asthma, chronic obstructive pulmonary disease (COPD), and other inflammatory diseases in women versus men (Fuseini and Newcomb 2017;Tsiligianni et al 2017;Center for Disease Control and Prevention, 2018;Shah and Newcomb 2018).…”

Section: Introductionmentioning

confidence: 99%

Modulation of the lung inflammatory response to ozone by the estrous cycle

et al. 2019

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Emerging evidence suggests that sex differences exist in the control of lung innate immunity; however, the specific roles of sex hormones in the inflammatory response, and the mechanisms involved are unclear. Here, we investigated whether fluctuations in circulating hormone levels occurring in the mouse estrous cycle could affect the inflammatory response to air pollution exposure. For this, we exposed female mice (C57 BL /6J, 8 weeks old) at different phases of the estrous cycle to 2 ppm of ozone or filtered air ( FA ) for 3 h. Following exposure, we collected lung tissue and bronchoalveolar lavage fluid ( BAL ), and performed lung function measurements to evaluate inflammatory responses and respiratory mechanics. We found a differential inflammatory response to ozone in females exposed in the luteal phase (metestrus, diestrus) versus the follicular phase (proestrus, estrus). Females exposed to ozone in the follicular phase had significantly higher expression of inflammatory genes, including Ccl2, Cxcl2, Ccl20, and Il6, compared to females exposed in the luteal phase ( P < 0.05), and displayed differential activation of regulatory pathways. Exposure to ozone in the follicular phase also resulted in higher BAL neutrophilia, lipocalin levels, and airway resistance than exposure in the luteal phase ( P < 0.05). Together, these results show that the effects of ozone exposure in the female lung are affected by the estrous cycle phase, and potentially hormonal status. Future studies investigating air pollution effects and inflammation in women should consider the menstrual cycle phase and/or circulating hormone levels.

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“…Our cohort had male preponderance which has been seen previously in case series with childhood ILD and HP. This has been described secondary to higher airway resistance of male infants compared with female counterparts which could lead to retention of antigens in airways of male infants . Our patients had persistent symptoms soon after lentil exposure with cough, fever, and shortness of breath being the most frequent features.…”

Section: Discussionmentioning

confidence: 67%

Lentil aspiration leading to likely hypersensitivity pneumonitis

Dhochak

Jat

Lodha

et al. 2019

Pediatric Pulmonology

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Rationale A variety of inhaled antigens have been implicated to cause hypersensitivity pneumonitis (HP). We observed that children force‐fed with lentil‐based weaning food had persistent respiratory symptoms and radiology similar to HP. Objectives To describe the clinical features of lentil HP. Methods We conducted a retrospective review of records of children with lentil HP attending Pediatric Chest Clinic at a tertiary care hospital in North India from 2008‐2018. We included case records with elevated immunoglobulin G (IgG) specific for lentil antigen. Measurements and Main Results Nine children (seven boys) were identified with median (IQR) age of onset of symptoms and diagnosis at 9 (6, 12) and 11 (10, 16) months, respectively. Chronic cough (100%), shortness of breath (89%), fever (78%), vomiting (56%), and wheezing (33%) were common symptoms. Fine crackles were heard in 33% of children, none had clubbing. CT scans showed nodular opacities and consolidation in 78% and 67% children, respectively. Bronchoalveolar lavage showed increased neutrophils and lymphocytes (67% and 33%, respectively). All children showed rapid remission with systemic steroids (prednisolone), starting at a median dose of 1 (1, 1.1) mg kg−1 day−1. One child had a clinical relapse which was treated with oral steroids again. IgG specific to lentil antigens was elevated in children with lentil HP (21‐>200 mgA/L) compared with children with other chronic respiratory illnesses (n = 7, <2‐11.4 mgA/L). Conclusions Lentil aspiration is an important cause of HP in infants of weaning age with force‐feeding practices. Further studies are needed to identify aspirated antigens which cause HP in aspiration prone children.

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Sex and the lung: Observations, hypotheses, and future directions

Cited by 69 publications

References 71 publications

The multi‐ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry

The multi‐ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry

Modulation of the lung inflammatory response to ozone by the estrous cycle

Lentil aspiration leading to likely hypersensitivity pneumonitis

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